SOCS3 negatively regulates LIF signaling in neural precursor cells

Emery, B.; Merson, T.D.; Snell, C.; Young, K.M.; Ernst, M.; Kilpatrick, T.J.

doi:10.1016/j.mcn.2006.01.005

SOCS3 negatively regulates LIF signaling in neural precursor cells

Cytokines that signal through the LIFRbeta/gp130 receptor complex, including LIF and CNTF, promote the self-renewal of embryonic and adult neural precursor cells (NPCs). In non-CNS tissues, the protein suppressor of cytokine signaling-3 (SOCS3) negatively regulates signaling through gp130. Here, …