A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching
Open accessAbstract
Several studies suggest a role for the amyloid precursor protein (APP) in neurite outgrowth and synaptogenesis, but the downstream interactions that mediate the function of APP during neuron development are unknown. By introducing interaction-deficient FE65 into cultured hippocampal neurons using adenovirus, we show that a complex including APP, FE65 and an additional protein is involved in neurite outgrowth at early stages of neuronal development. Both FE65 that is unable to interact with APP (PID2 mutants) or a WW mutant increased axon branching. Although the FE65 mutants did not affect total neurite output, both mutants decreased axon segment length, consistent with an overall slowing of axonal growth cones. FE65 mutants did not alter the localization of either APP or FE65 in axonal growth cones, suggesting that the effects on neurite outgrowth are achieved by alterations in local complex formation within the axonal growth cone.
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Apbb1 is an adapter protein that functions in neurite outgrowth and synaptic plasticity, processes linked to neurological disorders including ASD.
“Apbb1 is an adapter protein that functions in neurite outgrowth (Cheung et al., 2014; Ikin et al., 2007) and synaptic plasticity (Sabo et al., 2003), processes that have been linked to neurological disorders including ASD (Hussman et al., 2011)”
From A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains (2014) · cites this paper as Ikin et al., 2007
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References 32 · Cited by 38
- Authors
- Ikin, A. F., Sabo, S. L., Lanier, L. M., & Buxbaum, J. D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Stanford University (US)
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 35
- Issue
- 1
- Pages
- 57-63
- ISSN
- 1044-7431 (ISSN-L)
- PMC
- PMC3622246
- OpenAlex
- W1975830708
- Cited by
- 38
- References
- 32
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Health Assistance Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- amyloid precursor protein, Fe65, axon branching, neurite outgrowth, axonal growth cones, macromolecular complexes, neuronal development, synaptogenesis, hippocampal neurons, WW domain
- MeSH terms
- Animals, Axons, Cells, Cultured, Cytosol, Dendrites, Hippocampus, Nerve Tissue Proteins, Neuroglia, Neurons, Nuclear Proteins, Mutagenesis, Site-Directed, Amyloid beta-Protein Precursor, Macromolecular Substances, Cell Shape, Green Fluorescent Proteins, Mice
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