Hippocampal phenotypes in kalirin-deficient mice
Open accessAbstract
Regulation of forebrain cellular structure and function by small GTPase pathways is crucial for normal and pathological brain development and function. Kalirin is a brain-specific activator of Rho-like small GTPases implicated in neuropsychiatric disorders. We have recently demonstrated key roles for kalirin in cortical synaptic transmission, dendrite branching, spine density, and working memory. However, little is known about the impact of the complete absence of kalirin on the hippocampus in mice. We thus investigated hippocampal function, structure, and associated behavioral phenotypes in KALRN knockout (KO) mice we have recently generated. Here we show that KALRN KO mice had modest impairments in hippocampal LTP, but normal hippocampal synaptic transmission. In these mice, both context and cue-dependent fear conditioning were impaired. Spine density and dendrite morphology in hippocampal pyramidal neurons were not significantly affected in the KALRN KO mice, but small alterations in the gross morphology of the hippocampus were detected. These data suggest that hippocampal structure and function are more resilient to the complete loss of kalirin, and reveal impairments in fear learning. These studies allow the comparison of the phenotypes of different kalirin mutant mice and shed light on the brain region-specific functions of small GTPase signaling.
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Inhibiting Kalirin function alone has little effect on LTP.
“Although inhibiting Kalirin function alone has little effect on LTP (318, 319)”
From Synaptic memory and CaMKII (2023) · cites this paper as [319]
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References 44 · Cited by 34
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- Authors
- Xie, Z., Cahill, M. E., Radulovic, J., Wang, J., Campbell, S. L., Miller, C. A., Sweatt, J. D., & Penzes, P.
- Affiliations
- Northwestern University (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Penzes, Peter
- ORCID
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 46
- Issue
- 1
- Pages
- 45-54
- ISSN
- 1044-7431 (ISSN-L)
- PMC
- PMC3576140
- OpenAlex
- W2155820811
- Cited by
- 34
- References
- 44
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH-NIMH (R01MH071316, MH078064, MH57014, P01 MH074866)
- National Alliance for Autism Research (NAAR)
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Alzheimer's Association
- NIH-NINDS (R37 NS034696)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Kalirin, hippocampus, long-term potentiation, fear conditioning, hippocampal synaptic transmission, dendritic morphology, dendritic spine density, hippocampal pyramidal neurons, hippocampal structure
- MeSH terms
- Animals, Behavior, Animal, Cells, Cultured, Fear, Hippocampus, Humans, Male, Synaptic Transmission, Neuronal Plasticity, Phenotype, Long-Term Potentiation, Mice, Knockout, Guanine Nucleotide Exchange Factors, Mice
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