Isl1 is required for multiple aspects of motor neuron development
Open accessAbstract
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.
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CSF1Ri prevented the disease-associated suppression of Isl1 and Cacna2d2.
“Among other genes, CSF1Ri prevented the disease-associated suppression of Isl1 , a gene involved in motor neuron development (Liang et al. , 2011) the conditional deletion of which results in striatal cholinergic interneuron loss (Elshatory and Gan, 2008), as well as Cacna2d2 , mutations in which decrease Ca 2+ channel subunit expression and drive epileptic seizures (Barclay et al. , 2001; Pipp”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Liang et al., 2011
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References 49 · Cited by 100
- Authors
- Liang, X., Song, M.-R., Xu, Z., Lanuza, G. M., Liu, Y., Zhuang, T., Chen, Y., Pfaff, S. L., Evans, S. M., & Sun, Y.
- Affiliations
- Tongji University (CN)
- Gwangju Institute of Science and Technology (KR)
- Fundación Instituto Leloir (AR)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Sun, Yunfu
- ORCID
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 47
- Issue
- 3
- Pages
- 215-222
- ISSN
- 1044-7431 (ISSN-L)
- PMC
- PMC3200226
- OpenAlex
- W1963594713
- Cited by
- 100
- References
- 49
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 1
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- American Heart Association
- National Research Foundation
- National Natural Science Foundation of China (973 Program, 31071280)
- Science and Technology Commission of Shanghai Municipality
- National Research Foundation of Korea
- National Institutes of Health
- National Key Research and Development Program of China (2011CB504006)
- National Heart, Lung, and Blood Institute (R01HL070867)
- National Institute of Neurological Disorders and Stroke (R01NS054172, R01NS037116)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Isl1, Islet1, motor neuron development, LIM-homeodomain transcription factor, axon growth, spinal motoneurons
- MeSH terms
- Animals, Axons, Mice, Transgenic, Motor Neurons, Spinal Cord, Transcription Factors, Homeodomain Proteins, Embryonic Development, Mice, LIM-Homeodomain Proteins
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