The dendritic tree and brain disorders
Abstract
Dendrite morphogenesis is a complex but well-orchestrated process and includes the development of dendritic branches, forming characteristic dendrite arbors, and dendritic spines, allowing neurons to communicate with each other. Various studies report that many neuropsychiatric disorders are characterized by dendritic and synaptic pathology, including abnormal spine density and morphology, synapse loss, and aberrant synaptic signaling and plasticity. In this review, we discuss dendrite development and branching, and in specific, morphology, cytoskeletal architecture, and how the complexity of the dendrite tree and its functional capabilities are altered in various brain disorders. Identifying and understanding these changes in dendrite morphology are essential for understanding brain function in normal and disease states.
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Changes in morphological complexity, dendritic spine number, shape and plasticity are associated with several neuropsychiatric and neurological disorders, including schizophrenia, autism spectrum disorder, intellectual disability and epilepsy.
“changes in morphological complexity, dendritic spine number, shape and plasticity are associated with several neuropsychiatric and neurological disorders, including SCZ, ASD, ID and epilepsy.16, 17, 18, 19”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [16]
Disruption in dendritic morphogenesis, synaptogenesis or activity-dependent remodelling produces network-wide deficits in neuronal connectivity.
“A disruption in any of these processes produces network-wide deficits in neuronal connectivity”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [16]
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- Authors
- Kulkarni, V. A., & Firestein, B. L.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Firestein, Bonnie L.
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 50
- Issue
- 1
- Pages
- 10-20
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W1999372252
- Cited by
- 390
- References
- 248
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 26 · 2023: 22 · 2022: 23 · 2021: 29 · 2020: 56 · 2019: 28 · 2018: 32 · 2017: 26 · 2016: 41 · 2015: 30 · 2014: 22 · 2013: 19 · 2012: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- March of Dimes Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- dendritic trees, dendrite morphogenesis, dendritic branching, dendritic spines, synaptic loss, synaptic plasticity, synaptic signaling, neuropsychiatric disorders, cytoskeletal structure, dendritic morphology, brain disorders
- MeSH terms
- Animals, Axons, Mental Disorders, Brain, Cytoskeleton, Dendrites, Humans, Nervous System Diseases, Synapses, Mice
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