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Medical SAM adapter: Adapting segment anything model for medical image segmentation

Open access
Wu, Junde, Wang, Ziyue, Hong, Mingxuan, Ji, Wei, Fu, Huazhu, Xu, Yanwu, Xu, Min, Jin, Yueming·2025·Medical Image Analysis

Abstract

The Segment Anything Model (SAM) has recently gained popularity in the field of image segmentation due to its impressive capabilities in various segmentation tasks and its prompt-based interface. However, recent studies and individual experiments have shown that SAM underperforms in medical image segmentation due to the lack of medical-specific knowledge. This raises the question of how to enhance SAM's segmentation capability for medical images. We propose the Medical SAM Adapter (Med-SA), which is one of the first methods to integrate SAM into medical image segmentation. Med-SA uses a light yet effective adaptation technique instead of fine-tuning the SAM model, incorporating domain-specific medical knowledge into the segmentation model. We also propose Space-Depth Transpose (SD-Trans) to adapt 2D SAM to 3D medical images and Hyper-Prompting Adapter (HyP-Adpt) to achieve prompt-conditioned adaptation. Comprehensive evaluation experiments on 17 medical image segmentation tasks across various modalities demonstrate the superior performance of Med-SA while updating only 2% of the SAM parameters (13M). Our code is released at https://github.com/KidsWithTokens/Medical-SAM-Adapter.

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Metadata

Authors
Wu, J., Wang, Z., Hong, M., Ji, W., Fu, H., Xu, Y., Xu, M., & Jin, Y.
Venue
Medical Image Analysis
Publisher
Elsevier BV
Published
2025-05
Volume
102
Pages
103547
ISSN
1361-8415 (ISSN-L)
OpenAlex
W4408634392
Cited by
677
References
62
FWCI
196.13
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Medical SAM adapter: Adapting segment anything model for medical image segmentation. https://app.cochat.ai/papers/10.1016/j.media.2025.103547
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Wu, J., Wang, Z., Hong, M., Ji, W., Fu, H., Xu, Y., Xu, M., & Jin, Y. (2025). Medical SAM adapter: Adapting segment anything model for medical image segmentation. Medical Image Analysis. https://doi.org/10.1016/j.media.2025.103547

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