Apolipoprotein C-III, familial chylomicronemia syndrome, and olezarsen
Open accessAbstract
Reducing the synthesis of apoC-III reduces fasting triglycerides in individuals lacking lipoprotein lipase activity. Recently, Stroes et al. 1 published a phase 3 trial on the effects of olezarsen, a third-generation antisense oligonucleotide that blocks apoC-III mRNA, on triglycerides and risk of acute pancreatitis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ApoC-III is a key regulator of triglyceride metabolism, and its inhibition has been proven effective in lowering triglyceride levels in preclinical studies and early clinical trials.
“ApoC-III is a key regulator of triglyceride metabolism, and its inhibition has been proven effective in lowering triglyceride levels in preclinical studies and early clinical trials.”
From Efficacy and safety of Olezarsen in treating hypertriglyceridemia: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [6]
Cites
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome
Witztum, J. L., Gaudet, D., Freedman, S. D., Alexander, V. J., Digenio, A., Williams, K. R., Yang, Q., Hughes, S. G., Geary, R. S., Arca, M., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1715944 · Cited by 669 · see citing works
Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome
Stroes, E. S. G., Alexander, V. J., Karwatowska-Prokopczuk, E., Hegele, R. A., Arca, M., Ballantyne, C. M., Soran, H., Prohaska, T. A., Xia, S., Ginsberg, H. N., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2400201 · Cited by 271 · see citing works
Rosenson, R. S., Gaudet, D., Ballantyne, C. M., Baum, S. J., Bergeron, J., Kershaw, E. E., Moriarty, P. M., Rubba, P., Whitcomb, D. C., Banerjee, P., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02222-w · Cited by 140 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Saddique, M. N., Thapa, R., Khan, Y., Javaid, H., Khawar, M. M., Rehman, A., Dave, R., Raval, R., Hejmadi, S., Singh, P., et al. (2025) · Discover Medicine · doi:10.1007/s44337-025-00329-2 · Cited by 6 · see citing works
- Authors
- Valdivielso, P., & Coca Prieto, I.
- Affiliations
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Corresponding author
- Valdivielso, Pedro
- ORCID
- Valdivielso, Pedro
- Venue
- Med
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 5
- Issue
- 6
- Pages
- 493-494
- ISSN
- 2666-6340 (ISSN-L)
- OpenAlex
- W4399670862
- Cited by
- 5
- References
- 3
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Med (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Keywords
- olezarsen, apolipoprotein C-III, familial chylomicronemia syndrome, antisense oligonucleotides, acute pancreatitis, triglycerides, lipoprotein lipase deficiency, hypertriglyceridemia
- MeSH terms
- Benzimidazoles, Humans, Hyperlipoproteinemia Type I, Oligonucleotides, Pancreatitis, Triglycerides, Oligonucleotides, Antisense, Apolipoprotein C-III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
