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Cited by 13Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal and yeast genetics research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Genetic diversity and molecular epidemiology of Candida albicans from vulvovaginal candidiasis patients

Tian, Ji-yun, Yang, Yong-gang, Chen, Shi, Teng, Yong, Li, Xin-zheng·2021·Infection, Genetics and Evolution
DOI 10.1016/j.meegid.2021.104893
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Abstract

Candida albicans (C. albicans) is a common cause of vulvovaginal candidiasis (VVC). In this paper, the genetic diversity and molecular epidemiology of 173C. albicans strains were investigated by multilocus sequence typing (MLST). A total of 52 diploid sequence types (DSTs) were recognized, and 27 (51.9%) of which have not been reported in the MLST database. Genotyping was performed on the multiple isolates collected from patients with recurrent VVC (RVVC, referring to VVC which attacks more than 4 times in one year) in different acute infectious phases. The results showed that 59.1% (26/44) of the patients suffered a relapse, with DST 79 (65.4%) as the dominant genotype. The etiology of the remaining 40.9% (18/44) of patients was reinfection, and the main genotypes included DST 79 (33.3%), DST 124 (8.6%) and DST 1895 (8.6%). DST 79 (45%) and DST 1395 (7.5%) were the main isolates of VVC patients, while DST 79 (24.1%), DST 727 (6.9%), DST 732 (6.9%) and DST 1867 (6.9%) were the main types of healthy volunteers. The results of the genotypes between RVVC patients and other groups were statistically different. Furthermore, cluster analysis was carried out on 1468 isolates, among which 1337 were downloaded from the MLST database, 130 were divided into 8 Clades in the present study and the remaining one was taken as a singleton. 92.3% isolates from relapse patients, 58.3% isolates from re-infected patients, 77.5% isolates from VVC patients and 51.7% isolates from volunteers were distributed in Clade 1. The analysis of the genotypes of multiple isolates from RVVC patients further demonstrated that point mutation and loss of heterozygosity contributed to the microevolution of C. albicans.

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Crossref · 10.1016/j.meegid.2021.104893

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Metadata

Authors
Tian, J.-Y., Yang, Y.-G., Chen, S., Teng, Y., & Li, X.-Z.
Affiliations
Third People's Hospital of Hangzhou (CN)
Corresponding author
Tian, Ji-yun
ORCID
Venue
Infection, Genetics and Evolution
Publisher
Elsevier BV
Published
2021-08
Volume
92
Pages
104893
ISSN
1567-1348 (ISSN-L)
DOI
10.1016/j.meegid.2021.104893
OpenAlex
W3159142315
Cited by
13
References
37
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2022: 3 · 2021: 1
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Infection Genetics and Evolution (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Candida albicans, vaginal candidiasis, recurrent vulvovaginal candidiasis, genetic diversity, molecular epidemiology, multilocus sequence typing, sequence types, clades, relapse, reinfection, loss of heterozygosity, point mutations, microevolution
MeSH terms
Candida albicans, Candidiasis, Vulvovaginal, China, Female, Humans, Genetic Variation, Prevalence, Molecular Epidemiology

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