Enhancement of psychotherapy using epigenetic modulating drugs
Open accessAbstract
Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modifications. This has implications for psychotherapy and long-term rehabilitation of CNS disorders. We hypothesize that by enhancing learning through pharmacologically manipulating 'epigenetic' parameters, the effects of psychotherapies and rehabilitation can be enhanced.
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Epigenetic drugs might serve to catalyze psychotherapeutic effects by enhancing learning and neuronal plasticity and facilitating fear extinction.
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From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Gavin, Chase, & Sharma, 2011
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References 49 · Cited by 6
- Authors
- Gavin, D. P., Chase, K. A., & Sharma, R. P.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Gavin, David P.
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 77
- Issue
- 1
- Pages
- 121-124
- ISSN
- 0306-9877 (ISSN-L)
- PMC
- PMC3110602
- OpenAlex
- W1987536602
- Cited by
- 6
- References
- 49
- Citations by year
- 2022: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2012: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- AstraZeneca
- National Institute of Mental Health (MH-069839, K01MH069839)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- epigenetic drugs, DNA methylation, histone modifications, memory consolidation, learning improvement, epigenetic memory
- MeSH terms
- Central Nervous System Diseases, Humans, Psychotherapy, Epigenesis, Genetic, Histone Deacetylase Inhibitors
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