Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-l-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in Horses
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Cyanobacteria-produced toxins (N-methylamino-L-alanine, saxitoxin, anatoxin) have been shown to exacerbate AD pathology.
“These toxins have been shown to exacerbate AD pathology [586, 587].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [587]
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References 4 · Cited by 107
- Authors
- Brenner, S. R.
- Affiliations
- Saint Louis University (US)
- Corresponding author
- Brenner, Steven R.
- ORCID
- Brenner, Steven R.
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 80
- Issue
- 1
- Pages
- 103
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2161597809
- Cited by
- 107
- References
- 4
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 22 · 2020: 13 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 3
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Environmental Science › Environmental Chemistry › Marine Toxins and Detection Methods
- Keywords
- gut microbiota, gut dysbiosis, gut-brain axis, neurodegenerative diseases, cyanobacteria, BMAA, neurotoxins, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, frontotemporal lobar degeneration, neuroinflammation, autophagy, proteinopathies, equine motor neuron disease, prebiotics, probiotics, synbiotics, fecal microbiota transplantation
- MeSH terms
- Cyanobacteria Toxins, Cyanobacteria, Alzheimer Disease, Amino Acids, Diamino, Amyotrophic Lateral Sclerosis, Animals, Horse Diseases, Horses, Humans, Models, Biological, Neurotoxins, Parkinson Disease, Supranuclear Palsy, Progressive, Motor Neuron Disease, Metagenome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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