In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms
Abstract
Recent studies reported over-expression of a cytokine (Interleukin (IL)-18) in the serum of sporadic amyotrophic lateral sclerosis (sALS) patients. Here, we report on the first-time detection of in-situ expression of activated IL-18 in the human brain in sALS patients. We also detected cerebral in-situ expression of key-molecules known to be closely related to the molecular network associated with the activation/secretion of IL-18 cytokine, namely, the receptor-interacting serine/threonine-protein kinase 3 (RIPK3 or RIP3), NOD-like receptor pyrin domain containing 3 (NLRP3)-inflammasome, and activated caspase-1. These findings suggest and allow to hypothesize that there might be a role for this cytokine network in molecular mechanisms associated with or implicated in the physiopathology of this neurodegenerative disorder.
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ALS patients are associated with increased expression of NLRP3 and caspase-1 in the brain.
“In line with this finding, ALS patients are also found to be associated with increased expression of NLRP3 and caspase-1 in the brain.366”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [366]
Cites
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Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis
Italiani, P., Carlesi, C., Giungato, P., Puxeddu, I., Borroni, B., Bossù, P., Migliorini, P., Siciliano, G., & Boraschi, D. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-94 · Cited by 103 · see citing works
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Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
The Role of the Inflammasome in Neurodegenerative Diseases
Piancone, F., La Rosa, F., Marventano, I., Saresella, M., & Clerici, M. (2021) · Molecules · doi:10.3390/molecules26040953 · Cited by 144 · see citing works
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- Authors
- Kadhim, H., Deltenre, P., Martin, J.-J., & Sébire, G.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Antwerp (BE)
- Montreal Children's Hospital (CA)
- Corresponding author
- Kadhim, Hazim
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 86
- Pages
- 14-17
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2197386596
- Cited by
- 54
- References
- 3
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 16 · 2021: 9 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Fondation Brugmann
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- IL-18, sporadic ALS, human brain, RIPK3, NLRP3 inflammasome, caspase-1, neuroinflammation, neurodegeneration, immune-inflammatory mechanisms
- MeSH terms
- Amyotrophic Lateral Sclerosis, Brain, Encephalitis, Humans, Immunity, Innate, Models, Neurological, Models, Immunological, Inflammation Mediators, Interleukin-18
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