Oxytocin intranasal administration as a new hope for hypogonadotropic hypogonadism patients
Abstract
Hypogonadotropic hypogonadism (HH) is a form of hypogonadism which also known as secondary or central hypogonadism. Congenital HH can occur due to defect in gonadotropin releasing hormone (GnRH) neurons, upstream regulators of GnRH neurons or pituitary gonadotropic cells. Testosterone or gonadotropins therapy are widely used to treat HH patients, however both have undesirable effects and GnRH treatment for HH patients is time and cost consuming. Direct delivery of therapeutics to the brain via the nasal route is located in the center of attention during the last decade and trial application of intranasal oxytocin as a method of enhancing social interactions are reported. It has been delineated that oxytocin stimulates GnRH release from the rat hypothalamic explants and intranasal applied oxytocin up-regulates GnRH expression in the male rat hypothalamus. Therefore application of intranasal oxytocin might be a new strategy to cure HH patients.
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Oxytocin has been shown to stimulate GnRH release.
“Similarly, oxytocin has also been shown to stimulate GnRH release, and it has been hypothesized that intranasal oxytocin may be a potential therapeutic option for testosterone deficiency in the future (77,78).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [78]
Cites
Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., Serin, A., Mungan, N. O., Cook, J. R., Ozbek, M. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.306 · Cited by 961 · see citing works
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Non-testosterone management of male hypogonadism: an examination of the existing literature
Krzastek, S. C., & Smith, R. P. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.11.16 · Cited by 34 · see citing works
“hypothesized that intranasal oxytocin may be a potential therapeutic option for testosterone deficiency in the future (77,78).”
Background
- Authors
- Salehi, M. S., Pandamooz, S., & Khazali, H.
- Affiliations
- Shahid Beheshti University (IR)
- Corresponding author
- Salehi, Mohammad Saied
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 109
- Pages
- 88-89
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2760753981
- Cited by
- 5
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 2 · 2020: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- intranasal oxytocin, hypogonadotropic hypogonadism, GnRH neurons, central hypogonadism, testosterone replacement therapy, gonadotropin therapy, GnRH agonist therapy, hypothalamic explants
- MeSH terms
- Administration, Intranasal, Animals, Central Nervous System, Gonadotropins, Hypogonadism, Hypothalamus, Gonadotropin-Releasing Hormone, Male, Models, Theoretical, Neurons, Oxytocin, Testosterone, Up-Regulation, Rats
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