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Cited by 169Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid MetabolismLipid metabolism and disorders

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.

Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells

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Kim, Min Sun, Sweeney, Trevor R., Shigenaga, Judy K., Chui, Lisa G., Moser, Arthur, Grunfeld, Carl, Feingold, Kenneth R.·2007·Metabolism
DOI 10.1016/j.metabol.2006.10.007PMC PMC2700944
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Abstract

During the acute phase response, cytokines induce marked alterations in lipid metabolism including an increase in serum triglyceride levels and a decrease in hepatic fatty acid oxidation, in bile acid synthesis, and in high-density lipoprotein levels. Here we demonstrate that tumor necrosis factor (TNF) and interleukin 1 (IL-1), but not IL-6, decrease the expression of retinoid X receptor alpha (RXRalpha), peroxisome proliferator-activated receptor alpha (PPARalpha), PPARgamma, liver X receptor alpha (LXRalpha), and coactivators PPARgamma coactivator 1alpha (PGC-1alpha), PGC-1beta, and steroid receptor coactivator 1 (SRC-1) in Hep3B human hepatoma cells. In addition, treatment of mice with TNF and IL-1 also decreased RXRalpha, PPARalpha, PPARgamma, LXRalpha, and PGC-1alpha messenger RNA (mRNA) levels in the liver. These decreases were accompanied by reduced binding of nuclear extracts to RXR, PPAR, and LXR response elements and decreased luciferase activity driven by PPAR and LXR response elements. In addition, the mRNA levels of proteins regulated by PPARalpha (carnitine palmitoyltransferase 1alpha) and LXR (sterol regulatory element binding protein) were decreased in Hep3B cells treated with TNF or IL-1. Finally, using constructs of the LXRalpha promoter or the PGC-1alpha promoter linked to luciferase, we were able to demonstrate that a decrease in transcription contributes to the reduction in mRNA levels of nuclear hormone receptors and coactivators. Thus, our results suggest that decreased expression of nuclear hormone receptors RXRalpha, PPARalpha, PPARgamma, and LXRalpha, as well as coactivators PGC-1alpha, PGC-1beta, and SRC-1 may contribute to the cytokine-induced alterations in hepatic lipid metabolism during the acute phase response.

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Crossref · 10.1016/j.metabol.2006.10.007

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Metadata

Authors
Kim, M. S., Sweeney, T. R., Shigenaga, J. K., Chui, L. G., Moser, A., Grunfeld, C., & Feingold, K. R.
Affiliations
  • University of California, San Francisco (US)
  • San Francisco VA Medical Center (US)
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2007-02
Volume
56
Issue
2
Pages
267-279
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2006.10.007
PMC
PMC2700944
OpenAlex
W1966030580
Cited by
168
References
44
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 11
FWCI
7.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD029706, R01 HD29706)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
TNF-α, interleukin-1, acute phase response, nuclear receptors, retinoid X receptor alpha, PPARα, PPARγ, liver X receptor alpha, PGC-1α, PGC-1β, SRC-1, transcriptional coactivator, hepatic lipid metabolism, hepatocytes, SREBP, cytokine-induced gene expression
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Liver X Receptors, Acute-Phase Reaction, Animals, Cell Nucleus, DNA-Binding Proteins, Interleukin-1, Liver, Mice, Inbred C57BL, Receptors, Cell Surface, RNA, Messenger, Transcription Factors, Transfection, Blotting, Northern, Blotting, Western, Trans-Activators, Receptors, Cytoplasmic and Nuclear, Hepatocytes, Retinoid X Receptor alpha, PPAR alpha, PPAR gamma, Tumor Necrosis Factors, Mice, Histone Acetyltransferases, Nuclear Receptor Coactivator 1, Orphan Nuclear Receptors

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