Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program

Goldberg, Ronald B.; Temprosa, Marinella; Mele, Lisa; Orchard, Trevor; Mather, Kieren; Bray, George; Horton, Edward; Kitabchi, Abbas; Krakoff, Jonathan; Marcovina, Santica; Perreault, Leigh; White, Neil

doi:10.1016/j.metabol.2015.11.011

Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program

Objective In addition to slowing diabetes development among participants in the Diabetes Prevention Program (DPP), intensive lifestyle change and metformin raised HDL-cholesterol (HDL-C) compared to placebo treatment. We investigated the lifestyle and metabolic determinants as well as effects of …