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Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models

Abbasi, Ebrahim, Goodarzi, Mohammad Taghi, Tayebinia, Heidar, Saidijam, Massoud, Khodadadi, Iraj·2021·Metabolism Open
DOI 10.1016/j.metop.2021.100140PMC PMC8526761
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Fig. 1 Effect of Anethum extract and dill tablet on liver cholesterol (top) and triglyceride contents (bottom). Dill tablet and hydroalcoholic extract of dill significantly reduced liver triglyceride (TG) and cholesterol in HC-HF group. Data were presented as the mean ± S.D. ∗∗∗p < 0.001, ∗∗ p < 0.01 and ∗p < 0.05 compared with HC-HF group. ###p < 0.001 and ##p < 0.01 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.
Fig. 1 Effect of Anethum extract and dill tablet on liver cholesterol (top) and triglyceride contents (bottom). Dill tablet and hydroalcoholic extract of dill significantly reduced liver triglyceride (TG) and cholesterol in HC-HF group. Data were presented as the mean ± S.D. ∗∗∗p < 0.001, ∗∗ p < 0.01 and ∗p < 0.05 compared with HC-HF group. ###p < 0.001 and ##p < 0.01 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.CC BY-NC-ND · PubMed Central
Fig. 2 Effect of Anethum extract and dill tablet on liver total antioxidant capacity (top) and malondialdehyde levels (bottom). Dill tablet and hydroalcoholic extract of dill significantly increased TAC and decreased MDA levels in HC-HF group. All values are presented as mg/gram tissue. Data were presented as the mean ± S.D. ∗∗∗p < 0.001 and ∗p < 0.05 compared with HC-HF group. ###p < 0.001 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.
Fig. 2 Effect of Anethum extract and dill tablet on liver total antioxidant capacity (top) and malondialdehyde levels (bottom). Dill tablet and hydroalcoholic extract of dill significantly increased TAC and decreased MDA levels in HC-HF group. All values are presented as mg/gram tissue. Data were presented as the mean ± S.D. ∗∗∗p < 0.001 and ∗p < 0.05 compared with HC-HF group. ###p < 0.001 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.CC BY-NC-ND · PubMed Central
Fig. 3 Effect of Anethum extract and dill tablet on cholesterol 7- alpha hydroxylase gene expression in different group. Data were presented as the mean ± S.D. ∗∗∗p < 0.001 compared with HC-HF group and ###p < 0.001 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.
Fig. 3 Effect of Anethum extract and dill tablet on cholesterol 7- alpha hydroxylase gene expression in different group. Data were presented as the mean ± S.D. ∗∗∗p < 0.001 compared with HC-HF group and ###p < 0.001 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.CC BY-NC-ND · PubMed Central
Fig. 4 Effect of Anethum extract and dill tablet on cholesterol 7 alpha-hydroxylase protein level. Dill tablet and hydroalcoholic extract of dill significantly increased this protein concentration in HC-HF group compared with untreated animals. Data were presented as the mean ± S.D. ∗∗∗p < 0.001, ∗∗ p < 0.01 and ∗p < 0.05 compared with HC-HF group. #p < 0.05 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.
Fig. 4 Effect of Anethum extract and dill tablet on cholesterol 7 alpha-hydroxylase protein level. Dill tablet and hydroalcoholic extract of dill significantly increased this protein concentration in HC-HF group compared with untreated animals. Data were presented as the mean ± S.D. ∗∗∗p < 0.001, ∗∗ p < 0.01 and ∗p < 0.05 compared with HC-HF group. #p < 0.05 compared with normal group. HC-HF; high cholesterol-high fat diet, ND: normal diet.CC BY-NC-ND · PubMed Central
Fig. 5 Effect of Anethum extract and dill tablet on liver morphology based on H&E staining. histopathological examination of liver showed that treatment of HC-HF treated animal with dill (Anethum) extract and tablet alleviated structural changes compared with untreated rats (magnification 100 × and 400 × ). Black arrow: central vein, red arrow: sinusoidal space, blue arrow: hepatocyte, purple arrow: foam cell, green arrow: necrotic cell. A: Control, B: Control + dill tablet, C: Control + dill extract, D: HC-HF, C: HC-HF + dill tablet, F: HC-HF + dill extract. HC-HF; high cholesterol-high fat diet. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 Effect of Anethum extract and dill tablet on liver morphology based on H&E staining. histopathological examination of liver showed that treatment of HC-HF treated animal with dill (Anethum) extract and tablet alleviated structural changes compared with untreated rats (magnification 100 × and 400 × ). Black arrow: central vein, red arrow: sinusoidal space, blue arrow: hepatocyte, purple arrow: foam cell, green arrow: necrotic cell. A: Control, B: Control + dill tablet, C: Control + dill extract, D: HC-HF, C: HC-HF + dill tablet, F: HC-HF + dill extract. HC-HF; high cholesterol-high fat diet. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)CC BY-NC-ND · PubMed Central
Fig. 6 Effect of Anethum extract and dill tablet on liver morphology and nonalcoholic fatty liver disease activity score (NAS).
Fig. 6 Effect of Anethum extract and dill tablet on liver morphology and nonalcoholic fatty liver disease activity score (NAS).CC BY-NC-ND · PubMed Central

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Citations

Cites

Research works printed but not linked: 38

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Metadata

Authors
Abbasi, E., Goodarzi, M. T., Tayebinia, H., Saidijam, M., & Khodadadi, I.
ORCID
Goodarzi, Mohammad Taghi
Venue
Metabolism Open
Publisher
Elsevier BV
Published
2021-12
Volume
12
Pages
100140
ISSN
2589-9368
DOI
10.1016/j.metop.2021.100140
PMC
PMC8526761
Cited by
9
References
1
Language
en
Licence
Funders
Hamadan University of Medical Sciences (9304031568)

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