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To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?
Open accessAbstract
Mycobacterium tuberculosis is the causative agent of the global tuberculosis epidemic. To combat this successful human pathogen we need a better understanding of the basic biology of mycobacterial pathogenesis. The use of mycobacterial model systems has the potential to greatly facilitate our understanding of how M. tuberculosis causes disease. Recently, studies using mycobacterial models, including M. bovis BCG, M. marinum, and M. smegmatis have significantly contributed to understanding M. tuberculosis. Specifically, there have been advances in genetic manipulation of M. tuberculosis using inducible promoters and recombineering that alleviate technical limitations in working with mycobacteria. Model systems have helped elucidate how secretion systems function at both the molecular level and during virulence. Mycobacterial models have also led to interesting hypotheses about how M. tuberculosis mediates latent infection and host response. While there is utility in using model systems to understand tuberculosis, each of these models represent distinct mycobacterial species with unique environmental adaptations. Directly comparing findings in model mycobacteria to those in M. tuberculosis will illuminate the similarities and differences between these species and increase our understanding of why M. tuberculosis is such a potent human pathogen.
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“Two alternative, slow-growing mycobacteria that are more closely related to M. tuberculosis and used in a BSL-2 laboratory are M. bovis BCG, the attenuated vaccine strain, and M. marinum, a fish pathogen, each with advantages for host infection studies over M. smegmatis (182, 183).”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [183]
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“each with advantages for host infection studies over M. smegmatis (182, 183)”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [183]
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Metadata
- Authors
- Shiloh, M. U., & DiGiuseppe Champion, P. A.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Shiloh, Michael U
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 13
- Issue
- 1
- Pages
- 86-92
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC2876343
- OpenAlex
- W2070413611
- Cited by
- 137
- References
- 50
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (K08AI076632)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- Mycobacterium tuberculosis, tuberculosis pathogenesis, Mycobacterium bovis BCG, Mycobacterium marinum, Mycobacterium smegmatis, secretion systems, virulence, latent infection, host response, recombineering, inducible promoters
- MeSH terms
- Humans, Models, Biological, Mycobacterium bovis, Mycobacterium tuberculosis, Tuberculosis, Virulence, Mycobacterium smegmatis, Host-Pathogen Interactions
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