Antibiotic resistance gene spread due to manure application on agricultural fields
Abstract
The usage of antibiotics in animal husbandry has promoted the development and abundance of antibiotic resistance in farm environments. Manure has become a reservoir of resistant bacteria and antibiotic compounds, and its application to agricultural soils is assumed to significantly increase antibiotic resistance genes and selection of resistant bacterial populations in soil. The genome location of resistance genes is likely to shift towards mobile genetic elements such as broad-host-range plasmids, integrons, and transposable elements. Horizontal transfer of these elements to bacteria adapted to soil or other habitats supports their environmental transmission independent of the original host. The human exposure to soil-borne resistance has yet to be determined, but is likely to be severely underestimated.
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Other risks to the environment associated with manure are spread of antibiotic resistant bacteria and metal(loid)s.
“Other risks to the environment associated with manure are the spread of antibiotic resistant bacteria (Heuer et al., 2011) and metal(loid)s (Dach and Starmans, 2005).”
From Intensify production, transform biomass to energy and novel goods and protect soils in Europe—A vision how to mobilize marginal lands (2018) · cites this paper as Heuer et al., 2011
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References 81 · Cited by 985
- Authors
- Heuer, H., Schmitt, H., & Smalla, K.
- Affiliations
- Julius Kühn-Institut (DE)
- Utrecht University (NL)
- Corresponding author
- Heuer, Holger
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 14
- Issue
- 3
- Pages
- 236-243
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W1980863376
- Cited by
- 985
- References
- 81
- Citations by year
- 2026: 47 · 2025: 61 · 2024: 50 · 2023: 63 · 2022: 85 · 2021: 102 · 2020: 104 · 2019: 80 · 2018: 84 · 2017: 67 · 2016: 67 · 2015: 41 · 2014: 53 · 2013: 48 · 2012: 28
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Funders
- German Research Foundation (DFG SM59/5-2)
- Netherlands Organization for Scientific Research (NWO)
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- antibiotic resistance genes, manure application, agricultural soils, antibiotic use in livestock, drug-resistant bacteria, mobile genetic elements, integrons, broad-host-range plasmids, transposable elements, horizontal gene transfer
- MeSH terms
- Agriculture, Animals, Anti-Bacterial Agents, Bacteria, Humans, Manure, Selection, Genetic, Interspersed Repetitive Sequences, Gene Transfer, Horizontal, Drug Resistance, Bacterial
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