Evolution of virulence in the Mycobacterium tuberculosis complex
Abstract
Mycobacterium tuberculosis, the causative agent of human tuberculosis is one of the most widely spread human pathogens. It has succeeded to infect a quarter of the global human population by developing most sophisticated ways to circumvent innate and adaptive immune defences. This highly specialized, major human pathogen has evolved from a pool of ancestral environmental mycobacteria, whose extant representatives are known under the name of Mycobacterium canettii. Recent whole genome analyses in combination with different phenotypic screens have provided key insights into the evolution of M. tuberculosis and closely related members regrouped in the M. tuberculosis complex (MTBC). They have also elucidated novel virulence determinants that are essential for these obligate pathogens. In this review, we present the most recent evolutionary models of the MTBC and various factors that have contributed to the outstanding evolutionary success of the tuberculosis agent.
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In contrast to M. canettii strains, DNA transfer between M. tuberculosis strains was not observed despite numerous trials, emphasizing the clonal population structure of M. tuberculosis strains.
“In contrast to M. canettii strains, DNA transfer between M. tuberculosis strains was not observed despite numerous trials (55), emphasizing the clonal population structure of M. tuberculosis strains (58,59).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [59]
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References 58 · Cited by 107
- Authors
- Orgeur, M., & Brosch, R.
- Affiliations
- Institut Pasteur (FR)
- Corresponding author
- Brosch, Roland
- ORCID
- Brosch, Roland
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 41
- Pages
- 68-75
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2771278397
- Cited by
- 107
- References
- 58
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 11 · 2023: 10 · 2022: 7 · 2021: 15 · 2020: 18 · 2019: 16 · 2018: 7
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence National de Recherche (ANR-10-LABX-62-IBEID, ANR-16-CE15-0003, ANR-16-CE35-0009)
- Fondation pour la Recherche Médicale (SPF20160936136, DEQ20130326471)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- Mycobacterium tuberculosis, Mycobacterium tuberculosis complex, virulence evolution, Mycobacterium canettii, nontuberculous mycobacteria, host immune evasion, virulence factors, whole-genome analysis, evolutionary models, tuberculosis pathogenesis
- MeSH terms
- Humans, Mycobacterium tuberculosis, Phylogeny, Tuberculosis, Virulence, Genome, Bacterial, Evolution, Molecular, Virulence Factors, Host-Pathogen Interactions
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