Candida albicans biofilm growth and dispersal: contributions to pathogenesis
Open accessAbstract
The fungal species Candida albicans is most frequently associated with biofilm formation in immune-compromised and medically compromised patients, and it is now firmly established that biofilm formation represents a major virulence factor during candidiasis. A growing body of evidence has demonstrated that C. albicans biofilm development is a highly regulated and coordinated process, where adhesive interactions, morphogenetic conversions, and consortial behavior play significant roles. Cells within the biofilms are protected from environmental stresses including host immune defenses and antifungal treatment, which carries important clinical consequences for the treatment of biofilm-associated infections. Dispersal of cells from biofilms represents one of the hallmarks of the biofilm life-style, and in the case of C. albicans dispersed cells are responsible for candidemia and dissemination leading to the establishment of invasive disease.
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Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which complicates therapy of these infections.
“Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections.”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [9]
A majority of manifestations of infections caused by Candida spp are associated with a biofilm etiology.
“A majority of manifestations of infections caused by Candida spp are associated with a biofilm etiology [5,8,9].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [9]
Candida cells within biofilms are protected from a variety of environmental stresses, including host defenses and antifungal treatment, and biofilm development contributes greatly to the pathogenesis of candidiasis and complicates treatment.
“Furthermore, Candida cells within these highly organized structures are protected from a variety of environmental stresses, including host defenses and antifungal treatment, and as such biofilm development contributes greatly to the pathogenesis of candidiasis and greatly complicates treatment for these patients [5,9].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [9]
Among pathogenic fungi, Candida spp. are the most frequently associated with biofilm formation.
“among pathogenic fungi, Candida spp. are the most frequently associated with biofilm formation [5,8,9].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [9]
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References 44 · Cited by 263
- Authors
- Wall, G., Montelongo-Jauregui, D., Vidal Bonifacio, B., Lopez-Ribot, J. L., & Uppuluri, P.
- Affiliations
- The University of Texas at San Antonio (US)
- The Lundquist Institute (US)
- Corresponding author
- Lopez-Ribot, Jose L
- Uppuluri, Priya
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 52
- Pages
- 1-6
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC6842673
- OpenAlex
- W2946908776
- Cited by
- 263
- References
- 44
- Citations by year
- 2026: 25 · 2025: 48 · 2024: 40 · 2023: 34 · 2022: 53 · 2021: 37 · 2020: 23 · 2019: 3
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida albicans, biofilm formation, biofilm dispersal, candidiasis, virulence factors, morphogenesis, cell adhesion, antifungal resistance, immune evasion, candidemia, invasive candidiasis, pathogenesis
- MeSH terms
- Animals, Candida albicans, Candidiasis, Humans, Virulence, Biofilms
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