Structures of the lectins from Pseudomonas aeruginosa: insights into the molecular basis for host glycan recognition
Open accessAbstract
The opportunistic human pathogen Psuedomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL adn PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.
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Pathogens such as Vibrio cholerae, Salmonella or Pseudomonas aeruginosa bind to mannose-containing glycoconjugates on the host intestinal surface.
“In addition, pathogens such as Vibrio cholerae, Salmonella or Pseudomonas aeruginosa bind to mannose-containing glycoconjugates on the host intestinal surface [49–51].”
From Bistable auto-aggregation phenotype in Lactiplantibacillus plantarum emerges after cultivation in in vitro colonic microbiota (2021) · cites this paper as [50]
The Introduction says Pseudomonas aeruginosa binds host mucins and cell-surface glycoconjugates, and section 4.2 describes its mannose-binding lectin PA-IIL. The paper does not establish that the mannose-containing targets are on the host intestinal surface. The other two pathogens may be covered by the sentence’s other citations and are not assessed against this source. (LLM, conf=0.85)
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References 42 · Cited by 314
Research works printed but not linked: 2
- N. Gilboa-Garber, Multiple aspects of Pseudomonas aeruginosa lec- tins, Nova Acta Leopoldina NF 75 301, 1997, pp. 153-177.
- N. Gilboa-Garber, D. Sudakevitz, The use of Pseudomonas aerugi- nosa lectin preparations as a vaccine, in: E. Levy (Ed.), Advances in Pathology, Pergamon Press Ltd, Oxford, 1982, pp. 31-33.
- Authors
- Imberty, A., Wimmerová, M., Mitchell, E. P., & Gilboa-Garber, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Masaryk University (CZ)
- Bar-Ilan University (IL)
- Corresponding author
- Imberty, Anne
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 6
- Issue
- 2
- Pages
- 221-228
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W2083601141
- Cited by
- 314
- References
- 42
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 6 · 2022: 19 · 2021: 17 · 2020: 17 · 2019: 27 · 2018: 14 · 2017: 15 · 2016: 9 · 2015: 19 · 2014: 19 · 2013: 20 · 2012: 13
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bar-Ilan University
- Vrije Universiteit Brussel
- Narodowe Centrum Badań i Rozwoju
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Keywords
- Pseudomonas aeruginosa, lectins, galactose binding, virulence factors, cell adhesion, biofilm formation, protein structure
- MeSH terms
- Glycoproteins, Pseudomonas aeruginosa, Receptors, Immunologic, Adhesins, Bacterial, Lectins
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