The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The Isd locus is present in numerous other Gram-positive pathogens, including Listeria monocytogenes , Bacillus anthracis , and Clostridium tetani (103, 116).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [103]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
Mazmanian, S. K., Liu, G., Ton-That, H., & Schneewind, O. (1999) · Science · doi:10.1126/science.285.5428.760 · Cited by 1,053
Self-citationPassage of Heme-Iron Across the Envelope of Staphylococcus aureus
Mazmanian, S. K., Skaar, E. P., Gaspar, A. H., Humayun, M., Gornicki, P., Jelenska, J., Joachmiak, A., Missiakas, D. M., & Schneewind, O. (2003) · Science · doi:10.1126/science.1081147 · Cited by 593
Self-citationLack of a role for iron in the Lyme disease pathogen
Posey, J. E., & Gherardini, F. C. (2000) · Science · doi:10.1126/science.288.5471.1651 · Cited by 538
Mazmanian, S. K., Ton-That, H., Su, K., & Schneewind, O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032523999 · Cited by 372
Self-citationIsdG and IsdI, Heme-degrading Enzymes in the Cytoplasm of Staphylococcus aureus
Skaar, E. P., Gaspar, A. H., & Schneewind, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307952200 · Cited by 282
Self-citationIdentification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus
Etz, H., Minh, D. B., Henics, T., Dryla, A., Winkler, B., Triska, C., Boyd, A. P., Söllner, J., Schmidt, W., von Ahsen, U., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092569199 · Cited by 218
Processing of Heme and Heme-Containing Proteins by Bacteria
Stojiljkovic, I., & Perkins-Balding, D. (2002) · DNA and Cell Biology · doi:10.1089/104454902753759708 · Cited by 134
Drechsel, H., Freund, S., Nicholson, G., Haag, H., Jung, O., Z�hner, H., & Jung, G. (1993) · Biometals · doi:10.1007/bf00205858 · Cited by 112
Research works printed but not linked: 19
- Weems, 2001, The many faces of Staphylococcus aureus infection. Recognizing and managing its life-threatening manifestations, Postgrad. Med., 110, 24, 10.3810/pgm.2001.10.1042 · DOI · Paper page
- Rybak, 2001, Emergence of methicillin-resistant Staphylococcus aureus with intermediate glycopeptide resistance: clinical significance and treatment options, Drugs, 61, 1, 10.2165/00003495-200161010-00001 · DOI
- Weinberg, 1978, Iron and infection, Microbiol. Rev., 42, 45, 10.1128/mr.42.1.45-66.1978 · DOI · Paper page
- Sebulsky, 2000, Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus, J. Bacteriol., 182, 4394, 10.1128/JB.182.16.4394-4400.2000 · DOI · Paper page
- Taylor, 2002, Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein, Mol. Microbiol., 43, 1603, 10.1046/j.1365-2958.2002.02850.x · DOI
- Modun, 1999, The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase, Infect. Immun., 67, 1086, 10.1128/IAI.67.3.1086-1092.1999 · DOI · Paper page
- Vanderpool, 2001, The Bordetella bhu locus is required for heme iron utilization, J. Bacteriol., 183, 4278, 10.1128/JB.183.14.4278-4287.2001 · DOI
- Lei, 2002, Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes, Infect. Immun., 70, 4494, 10.1128/IAI.70.8.4494-4500.2002 · DOI · Paper page
- Drazek, 2000, Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters, Mol. Microbiol., 36, 68, 10.1046/j.1365-2958.2000.01818.x · DOI · Paper page
- Trivier, 1996, Iron depletion and virulence in Staphylococcus aureus, FEMS Microbiol. Lett., 141, 117, 10.1111/j.1574-6968.1996.tb08373.x · DOI · Paper page
- Elek, 1957, The virulence of Staphylococcus pyogenes for man; a study of the problems of wound infection, Br. J. Exp. Pathol., 38, 573
- Gladstone, 1971, The effect of iron and haematin on the killing of staphylococci by rabbit polymorphs, Br. J. Exp. Pathol., 52, 452
- Dryla, 2003, Identification of a novel iron regulated staphylococcal surface protein with haptoglobin–haemoglobin binding activity, Mol. Microbiol., 49, 37, 10.1046/j.1365-2958.2003.03542.x · DOI · Paper page
- Konetschny-Rapp, 1990, Staphyloferrin A: a structurally new siderophore from staphylococci, Eur. J. Biochem., 191, 65, 10.1111/j.1432-1033.1990.tb19094.x · DOI · Paper page
- Courcol, 1997, Siderophore production by Staphylococcus aureus and identification of iron-regulated proteins, Infect. Immun., 65, 1944, 10.1128/iai.65.5.1944-1948.1997 · DOI
- Mazmanian, 2001, Sortase-catalyzed anchoring of surface proteins to the cell wall of Staphylococcus aureus, Mol. Microbiol., 40, 1049, 10.1046/j.1365-2958.2001.02411.x · DOI · Paper page
- Jonsson, 2003, The role of Staphylococcus aureus sortase A and sortase B in murine arthritis, Microbes Infect., 5, 775, 10.1016/S1286-4579(03)00143-6 · DOI
- Maines, 1997, The heme oxygenase system: a regulator of second messenger gases, Annu. Rev. Pharmacol. Toxicol., 37, 517, 10.1146/annurev.pharmtox.37.1.517 · DOI
- Wilks, 2002, Heme oxygenase: evolution, structure, and mechanism, Antioxid. Redox Signal, 4, 603, 10.1089/15230860260220102 · DOI
Cited by
Sorted by citations
Staphylococcus aureus IsdB Is a Hemoglobin Receptor Required for Heme Iron Utilization
Torres, V. J., Pishchany, G., Humayun, M., Schneewind, O., & Skaar, E. P. (2006) · Journal of Bacteriology · doi:10.1128/jb.01335-06 · Cited by 302
Self-citationOvercoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens
Anzaldi, L. L., & Skaar, E. P. (2010) · Infection and Immunity · doi:10.1128/iai.00613-10 · Cited by 295
Self-citationKuklin, N. A., Clark, D. J., Secore, S., Cook, J., Cope, L. D., McNeely, T., Noble, L., Brown, M. J., Zorman, J. K., Wang, X. M., et al. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2215-2223.2006 · Cited by 264
Staphylococcal response to oxidative stress
Gaupp, R., Ledala, N., & Somerville, G. A. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00033 · Cited by 253
A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence
Torres, V. J., Stauff, D. L., Pishchany, G., Bezbradica, J. S., Gordy, L. E., Iturregui, J., Anderson, K. L., Dunman, P. M., Joyce, S., & Skaar, E. P. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.03.001 · Cited by 241
Self-citationStaphylococcus aureus Redirects Central Metabolism to Increase Iron Availability
Friedman, D. B., Stauff, D. L., Pishchany, G., Whitwell, C. W., Torres, V. J., & Skaar, E. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020087 · Cited by 222
Self-citationInhibition of staphylococcal biofilm formation by nitrite
Schlag, S., Nerz, C., Birkenstock, T. A., Altenberend, F., & Götz, F. (2007) · Journal of Bacteriology · doi:10.1128/jb.00598-07 · Cited by 196
Haem recognition by a Staphylococcus aureus NEAT domain
Grigg, J. C., Vermeiren, C. L., Heinrichs, D. E., & Murphy, M. E. P. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05502.x · Cited by 166
Torres, V. J., Attia, A. S., Mason, W. J., Hood, M. I., Corbin, B. D., Beasley, F. C., Anderson, K. L., Stauff, D. L., McDonald, W. H., Zimmerman, L. J., et al. (2010) · Infection and Immunity · doi:10.1128/iai.01423-09 · Cited by 169
Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus
Beasley, F. C., Vinés, E. D., Grigg, J. C., Zheng, Q., Liu, S., Lajoie, G. A., Murphy, M. E. P., & Heinrichs, D. E. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06698.x · Cited by 163
Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin
Maresso, A. W., Garufi, G., & Schneewind, O. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000132 · Cited by 144
Self-citationMuryoi, N., Tiedemann, M. T., Pluym, M., Cheung, J., Heinrichs, D. E., & Stillman, M. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802171200 · Cited by 144
Wu, R., Skaar, E. P., Zhang, R., Joachimiak, G., Gornicki, P., Schneewind, O., & Joachimiak, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409526200 · Cited by 144
Self-citationThe IsdG‐family of haem oxygenases degrades haem to a novel chromophore
Reniere, M. L., Ukpabi, G. N., Harry, S. R., Stec, D. F., Krull, R., Wright, D. W., Bachmann, B. O., Murphy, M. E., & Skaar, E. P. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07076.x · Cited by 139
Surface Protein IsdC and Sortase B Are Required for Heme-Iron Scavenging of Bacillus anthracis
Maresso, A. W., Chapa, T. J., & Schneewind, O. (2006) · Journal of Bacteriology · doi:10.1128/jb.01011-06 · Cited by 135
Self-citationBacillus anthracis IsdG, a Heme-Degrading Monooxygenase
Skaar, E. P., Gaspar, A. H., & Schneewind, O. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.3.1071-1080.2006 · Cited by 123
Self-citationPilpa, R. M., Robson, S. A., Villareal, V. A., Wong, M. L., Phillips, M., & Clubb, R. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806007200 · Cited by 118
Sharp, K. H., Schneider, S., Cockayne, A., & Paoli, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700234200 · Cited by 120
Lee, W. C., Reniere, M. L., Skaar, E. P., & Murphy, M. E. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709486200 · Cited by 117
Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes
Spaan, A. N., Reyes-Robles, T., Badiou, C., Cochet, S., Boguslawski, K. M., Yoong, P., Day, C. J., de Haas, C. J. C., van Kessel, K. P. M., Vandenesch, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.08.001 · Cited by 114
Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem
Reniere, M. L., & Skaar, E. P. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06363.x · Cited by 86
Bacillus anthracis HssRS signalling to HrtAB regulates haem resistance during infection
Stauff, D. L., & Skaar, E. P. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06684.x · Cited by 81
Stauff, D. L., Bagaley, D., Torres, V. J., Joyce, R., Anderson, K. L., Kuechenmeister, L., Dunman, P. M., & Skaar, E. P. (2008) · Journal of Bacteriology · doi:10.1128/jb.01921-07 · Cited by 83
Self-citationGaspar, A. H., Marraffini, L. A., Glass, E. M., DeBord, K. L., Ton-That, H., & Schneewind, O. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.13.4646-4655.2005 · Cited by 82
Self-citationSubcellular Localization of the Staphylococcus aureus Heme Iron Transport Components IsdA and IsdB
Pishchany, G., Dickey, S. E., & Skaar, E. P. (2009) · Infection and Immunity · doi:10.1128/iai.01531-08 · Cited by 77
Immune evasion by Staphylococcus aureus conferred by iron-regulated surface determinant protein IsdH
Visai, L., Yanagisawa, N., Josefsson, E., Tarkowski, A., Pezzali, I., Rooijakkers, S. H. M., Foster, T. J., & Speziale, P. (2009) · Microbiology · doi:10.1099/mic.0.025684-0 · Cited by 73
Dryla, A., Hoffmann, B., Gelbmann, D., Giefing, C., Hanner, M., Meinke, A., Anderson, A. S., Koppensteiner, W., Konrat, R., von Gabain, A., et al. (2007) · Journal of Bacteriology · doi:10.1128/jb.01366-06 · Cited by 73
Ouattara, M., Bentley Cunha, E., Li, X., Huang, Y., Dixon, D., & Eichenbaum, Z. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07367.x · Cited by 71
Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus
Grigg, J. C., Cheung, J., Heinrichs, D. E., & Murphy, M. E. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172924 · Cited by 71
Transferrin iron starvation therapy for lethal bacterial and fungal infections
Lin, L., Pantapalangkoor, P., Tan, B., Bruhn, K. W., Ho, T., Nielsen, T., Skaar, E. P., Zhang, Y., Bai, R., Wang, A., et al. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu049 · Cited by 68
Self-citationFabian, M., Solomaha, E., Olson, J. S., & Maresso, A. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040915 · Cited by 70
Gat, O., Zaide, G., Inbar, I., Grosfeld, H., Chitlaru, T., Levy, H., & Shafferman, A. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06460.x · Cited by 68
van Dijk, M. C., de Kruijff, R. M., & Hagedoorn, P.-L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.857237 · Cited by 41
HrtBA and menaquinones control haem homeostasis in Lactococcus lactis
Joubert, L., Derré‐Bobillot, A., Gaudu, P., Gruss, A., & Lechardeur, D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12705 · Cited by 32
Sæderup, K. L., Stødkilde, K., Graversen, J. H., Dickson, C. F., Etzerodt, A., Hansen, S. W. K., Fago, A., Gell, D., Andersen, C. B. F., & Moestrup, S. K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.755934 · Cited by 31
Fonner, B. A., Tripet, B. P., Eilers, B. J., Stanisich, J., Sullivan-Springhetti, R. K., Moore, R., Liu, M., Lei, B., & Copié, V. (2014) · Biochemistry · doi:10.1021/bi5005188 · Cited by 31
Reniere, M. L., Haley, K. P., & Skaar, E. P. (2011) · Biochemistry · doi:10.1021/bi200999q · Cited by 25
Metadata
- Authors
- P. Skaar, E., & Schneewind, O.
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 6
- Issue
- 4
- Pages
- 390-397
- ISSN
- 1286-4579
- Cited by
- 209
- References
- 8
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review