CoChat
Sign Up
Cited by 46Coccidia and coccidiosis researchAnimal Nutrition and PhysiologyProbiotics and Fermented Foods

The DOI matches its Crossref record; the references it cites are not checked yet.

Immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics on pathological effects of eimeriasis in broilers

Awais, Mian Muhammad, Jamal, Muhammad Asif, Akhtar, Masood, Hameed, Muhammad Raza, Anwar, Muhammad Irfan, Ullah, Muhammad Irfan·2019·Microbial Pathogenesis
DOI 10.1016/j.micpath.2018.10.038
Open this paper in CoChat — free account

Abstract

Eimeria infection is very important in broilers and causes heavy economic losses in extensive farming system due to reduced weight gains, high mortality and poor feed conversion ratio (FCR). Under the circumstances, there is a dire need to devise effective control strategies to avoid/counteract this infectious threat. This study was conducted to assess the immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics against Eimeria infection in broilers. The results showed statistically higher (P < 0.05) lymphoproliferative responses in experimental groups treated either with Lactobacillus or Saccharomyces based probiotics, as compared to control group. Further higher antibody titers (geomean titers) were also recorded in chickens of experimental groups treated with probiotics as compared to those of control group. The probiotic treated groups also revealed significantly improved (P < 0.05) FCRs as compared to control group. In challenge experiment, significantly lower (P < 0.05) oocyst counts were recorded in broilers treated with probiotics, when compared with control group. Further, experimental groups also revealed significantly higher (P < 0.05) daily weight gains and protection rates as compared to control. The data regarding the lesion scoring showed that chickens treated with probiotics had higher values of percent protection against intestinal and caecal lesion, when compared with those of control group. In conclusion, supplementation…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.micpath.2018.10.038

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

The citation lists haven’t been fetched yet

References 56 · Cited by 46

Research works printed but not linked: 56

  1. Awais, 2018, Evaluation of Saccharum officinarum L. bagasse-derived polysaccharides as native immunomodulatory and anticoccidial agents in broilers, Vet. Parasitol., 249, 74, 10.1016/j.vetpar.2017.11.012 · DOI
  2. Williams, 2005, Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity, Avian Pathol., 34, 159, 10.1080/03079450500112195 · DOI
  3. Dalloul, 2006, Poultry coccidiosis: recent advancements in control measures and vaccine development, Expert Rev. Vaccines, 5, 143, 10.1586/14760584.5.1.143 · DOI
  4. Arabkhazaeli, 2013, Evaluating the resistance of Eimeria spp. Field isolates to anticoccidial drugs using three different indices, Iran, J. Parasitol., 8, 234
  5. Chapman, 2002, Sustainable coccidiosis control in poultry production: the role of live vaccines, Int. J. Parasitol., 32, 617, 10.1016/S0020-7519(01)00362-9 · DOI
  6. Li, 2005, Responses of chickens vaccinated with a live attenuated multi-valent ionophore-tolerant Eimeria vaccine, Vet. Parasitol., 129, 179, 10.1016/j.vetpar.2004.09.034 · DOI
  7. Kogut, 1988, The role of lymphokines or gamma (γ) interferon in host defense of chickens to Eimeria tenella, Vet. Parasitol., 29, 295, 10.1016/0304-4017(88)90134-3 · DOI
  8. Patterson, 2003, Application of prebiotics and probiotics in poultry production, Poultry Sci., 82, 627, 10.1093/ps/82.4.627 · DOI
  9. Ritzi, 2014, Effects of probiotics and application methods on performance and response of broiler chickens to an Eimeria challenge, Poultry Sci., 93, 2772, 10.3382/ps.2014-04207 · DOI
  10. Ohimain, 2012, The effect of probiotic and prebiotic feed supplementation on chicken health and gut microflora: a review, Int. J. Anim. Vet. Adv., 4, 135
  11. Mountzouris, 2010, Effects of probiotic inclusion levels in broiler nutrition on growth performance, nutrient digestibility, plasma immunoglobulins, and cecal microflora composition, Poultry Sci., 89, 58, 10.3382/ps.2009-00308 · DOI
  12. Travers, 2011, Probiotics for the control of parasites: an overview, J. Parasitol. Res., 2011, 610769, 10.1155/2011/610769 · DOI
  13. Soltan Dallal, 2015, Effects of probiotic Lactobacillus acidophilus and Lactobacillus casei on colorectal tumor cells activity (CaCo-2), Arch. Iran. Med., 18, 167
  14. Higgins, 2007, Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers, Poultry Sci., 86, 1662, 10.1093/ps/86.8.1662 · DOI
  15. Hosoi T, 1999, Changes in fecal microflora induced by intubation of mice with Bacillus subtilis (natto) spores are dependent upon dietary components, Can. J. Microbiol., 45, 59, 10.1139/w98-206 · DOI
  16. Dalloul, 2005, Induction of local protective immunity to Eimeria acervulina by a Lactobacillus- based probiotic, Comp. Immunol. Microbiol. Infect. Dis., 28, 351, 10.1016/j.cimid.2005.09.001 · DOI
  17. Farnell, 2006, Upregulation of oxidative burst and degranulation in chicken heterophils stimulated with probiotic bacteria, Poultry Sci., 85, 1900, 10.1093/ps/85.11.1900 · DOI
  18. Gao, 2008, Effects of yeast culture in broiler diets on performance and immunomodulatory functions, Poultry Sci., 87, 1377, 10.3382/ps.2007-00418 · DOI
  19. Yalcin, 2008, Yeast culture supplementation to laying hen diets containing soybean meal or sunflower seed meal and its effect on performance, egg quality traits, and blood chemistry, J. Appl. Poultry Res., 17, 229, 10.3382/japr.2007-00064 · DOI
  20. Sonmez, 1999, Effects of supplementation of zinc bacitracin, mannan oligosaccharide, and probiotic into the broiler feeds on morphology of the small intestine, Uludag Univ. Vet. Fac. Derg., 18, 125
  21. Mountzouris, 2015, Evaluation of yeast dietary supplementation in broilers challenged or not with Salmonella on growth performance, cecal microbiota composition and Salmonella in ceca, cloacae and carcass skin, Poultry Sci., 94, 2445, 10.3382/ps/pev243 · DOI
  22. Awais, 2011, Immunotherapeutic effects of some sugarcane (SaccharumofficinarumL.) extracts against coccidiosis in industrial broiler chickens, Exp. Parasitol., 128, 104, 10.1016/j.exppara.2011.02.024 · DOI
  23. Ryley, 1976, Methods in coccidosis research: separation of oocysts from faeces, Parasitology, 73, 311, 10.1017/S0031182000046990 · DOI
  24. Corrier, 1990, Comparison of phytohemagglutinin-induced cutaneous hypersensitivity reactions in the interdigital skin of broiler and layer chicks, Avian Dis., 34, 369, 10.2307/1591421 · DOI
  25. Awais, 2013, Saccharum officinarum derived mid molecular mass glycoproteins as native BRMs in chickens, Pak. J. Life Soc. Sci., 11, 200
  26. Johnson, 1970, Anticoccidial drugs: lesion scorings techniques in battery and floor-pen experiments with chickens, Exp. Parasitol., 28, 30, 10.1016/0014-4894(70)90063-9 · DOI
  27. Khaliq, 2017, Evaluation of immunotherapeutic effects of Aloe vera polysaccharides against coccidiosis in chicken, Kafkas Univ. Vet. Fak. Derg., 23, 895
  28. Angelakis, 2013, Related actions of probiotics and antibiotics on gut microbiota and weight modification, Lancet, 13, 889, 10.1016/S1473-3099(13)70179-8 · DOI · Paper page
  29. Kechagia, 2013, Health benefits of probiotics: a Review, ISRN Nutrition, 2013, 481651, 10.5402/2013/481651 · DOI
  30. Edens, 2003, An alternative for antibiotic use in poultry: probiotics, Braz. J. Poult. Sci., 5, 75, 10.1590/S1516-635X2003000200001 · DOI
  31. Guarner, 2003, Gut flora in health and disease, Lancet, 361, 512, 10.1016/S0140-6736(03)12489-0 · DOI
  32. Lee, 2007, Influence of Pediococcus-based probiotics on coccidiosis in broiler chickens, Poultry Sci., 86, 63, 10.1093/ps/86.1.63 · DOI
  33. Lensing, 2012, Efficacy of Saccharomyces cerevisiae fermentation product on intestinal health and productivity of coccidian-challenged laying hens, Poultry Sci., 91, 1590, 10.3382/ps.2011-01508 · DOI
  34. Ashraf, 2014, Immune system stimulation by probiotic microorganisms, Crit. Rev. Food Sci. Nutr., 54, 938, 10.1080/10408398.2011.619671 · DOI
  35. Kamilya, 2015, Inactivated Probiotic bacteria stimulate cellular immune responses of Catlacatla (Hamilton) in Vitro, Probiotics Antimicrob Proteins, 7, 101, 10.1007/s12602-015-9191-9 · DOI
  36. Koenen, 2004, Immunomodulation by probiotic Lactobacillus in layer- and meat-type chickens, Br. Poultry Sci., 45, 355, 10.1080/00071660410001730851 · DOI
  37. Yuan, 2015, Yeast product supplementation modulated humoral and mucosal immunity and uterine inflammatory signals in transition dairy cows, J. Dairy Sci., 98, 3236, 10.3168/jds.2014-8469 · DOI
  38. Broadway, 2015, Live yeast and yeast cell wall supplements enhance immune function and performance in food-producing livestock: a review, Microorganisms, 3, 417, 10.3390/microorganisms3030417 · DOI
  39. Majtan, 2005, Stimulation of TNF-alpha release by fungal cell wall polysaccharides, Z. Naturforsch. C Biosci., 60, 921, 10.1515/znc-2005-11-1216 · DOI
  40. Xiao, 2004, A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins, BMC Genomics, 5, 56, 10.1186/1471-2164-5-56 · DOI
  41. Lammers, 2004, Adoptive transfer of natural antibodies to non-immunized chickens affects subsequent antigen-specific humoral and cellular immune responses, Dev. Comp. Immunol., 28, 51, 10.1016/S0145-305X(03)00102-2 · DOI
  42. Haghighi, 2005, Modulation of antibody-mediated immune response by probiotics in chickens, Clin. Diagn. Lab. Immunol., 12, 1387, 10.1128/CDLI.12.12.1387-1392.2005 · DOI
  43. Nikpiran, 2013, Influence of Probiotic and Prebiotic on broiler chicken's performance and immune status, J. Nov. Appl. Sci., 2, 256
  44. Hemaiswarya, 2013, Mechanism of action of probiotics, J. Braz. Arch. Biol. Technol., 56, 113, 10.1590/S1516-89132013000100015 · DOI
  45. Haldar, 2011, Effects of yeast (Saccharomyces cerevisiae) and yeast protein concentrate on production performance of broiler chickens exposed to heat stress and challenged with Salmonella enteritidis, Anim. Feed Sci. Technol., 168, 61, 10.1016/j.anifeedsci.2011.03.007 · DOI
  46. Wolfenden, 2011, Evaluation of selected direct-fed microbial candidates on live performance and Salmonella reduction in commercial Turkey brooding houses, Poultry Sci., 90, 2627, 10.3382/ps.2011-01360 · DOI
  47. Giannenas, 2014, Assessment of probiotics supplementation via feed or water on the growth performance, intestinal morphology and microflora of chickens after experimental infection with Eimeria acervulina, Eimeria maxima and Eimeria tenella, Avian Pathol., 43, 209, 10.1080/03079457.2014.899430 · DOI
  48. Patel, 2010, Evaluation of probiotics characteristics of Siderophoregenic Bacillus Spp. Isolated from dairy waste, Appl. Biochem. Biotechnol., 160, 140, 10.1007/s12010-009-8583-2 · DOI
  49. Liu, 2006, Dynamic changes of T lymphocyte subpopulations in immune organs of chicks infected with Eimeria necatrix, Acta Vet. Zootech. Sin., 37, 168
  50. Gil de los santos, 2005, Bacillus cereus var. toyoii and Saccharomyces boulardii increased feed efficiency in broilers infected with Salmonella enteritidis, Br. Poultry Sci., 46, 494, 10.1080/00071660500181461 · DOI
  51. Idris, 1997, Quantitative pathology of small intestinal coccidiosis caused by Eimeria maxima in young broilers, Avian Pathol., 26, 731, 10.1080/03079459708419249 · DOI
  52. Eizaguirre, 2002, Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome, J. Pediatr. Surg., 37, 699, 10.1053/jpsu.2002.32256 · DOI · Paper page
  53. Badran, 2006, Control of coccidiosis and different coccidia of chicken in selected technologies used in tropics and subtropics, Agric. Tropica Subtropica, 39, 39
  54. Chen, 2017, Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections, Mucosal Immunol., 10, 215, 10.1038/mi.2016.31 · DOI
  55. Haddaji, 2015, Effect of high temperature on viability of Lactobacillus casei and analysis of secreted and GroeL proteins profiles, African J. Bacteriol. Res., 7, 29
  56. Mohapatra, 2014, Beneficial effects of dietary probiotics mixture on hemato-immunology and cell apoptosis of labeorohita fingerlings reared at higher water temperatures, PloS One, 9, 10.1371/journal.pone.0100929 · DOI

Metadata

Authors
Awais, M. M., Jamal, M. A., Akhtar, M., Hameed, M. R., Anwar, M. I., & Ullah, M. I.
Affiliations
Bahauddin Zakariya University (PK)
Corresponding author
Awais, Mian Muhammad
ORCID
Venue
Microbial Pathogenesis
Publisher
Elsevier BV
Published
2019-01
Volume
126
Pages
101-108
ISSN
0882-4010 (ISSN-L)
DOI
10.1016/j.micpath.2018.10.038
OpenAlex
W2899139542
Cited by
46
References
56
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 4 · 2019: 1
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Microbial Pathogenesis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Coccidia and coccidiosis research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
probiotics, Lactobacillus, Saccharomyces, Eimeria infection, coccidiosis, broiler chickens, immunomodulation, antibody titers, lymphoproliferation, feed conversion ratio, oocyst count, intestinal lesions, caecal lesions, growth performance, poultry disease control
MeSH terms
Animals, Animal Feed, Chickens, Coccidiosis, Disease Models, Animal, Eimeria, Immunity, Intestines, Lactobacillus, Poultry Diseases, Saccharomyces cerevisiae, Weight Gain, Probiotics, Oocysts, Immunomodulation, Disease Resistance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics on pathological effects of eimeriasis in broilers. https://app.cochat.ai/papers/10.1016/j.micpath.2018.10.038
The paper
Awais, M. M., Jamal, M. A., Akhtar, M., Hameed, M. R., Anwar, M. I., & Ullah, M. I. (2019). Immunomodulatory and ameliorative effects of Lactobacillus and Saccharomyces based probiotics on pathological effects of eimeriasis in broilers. Microbial Pathogenesis. https://doi.org/10.1016/j.micpath.2018.10.038