Understanding the potential of lactobacilli in recurrent UTI prevention
Abstract
Urinary tract infections (UTIs) are one of the most common infections in women. The only proven preventive strategy for recurrent UTIs is prophylactic antibiotics. Given growing antibiotic resistance, the use of probiotics has been proposed as an alternative to antibiotics. Herein, we discuss the current evidence to support the possibility that exogenous lactobacilli may limit the pathogenicity of uropathogens such as E. coli. Probiotics appear to have a significant potential in prevention of recurrent UTI, however, additional data are needed to understand how they can be effectively used in clinical practice.
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Vaginal lactobacilli produce lactic acid, which helps maintain the acidic pH of the vagina.
“These bacteria produce lactic acid, which helps maintain the acidic pH of the vaginal acidic pH [32, 33].”
Cites
RoB 2: a revised tool for assessing risk of bias in randomised trials
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., et al. (2019) · BMJ · doi:10.1136/bmj.l4898 · Cited by 33,583 · see citing works
Llor, C., & Bjerrum, L. (2014) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098614554919 · Cited by 2,079 · see citing works
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- Authors
- Vagios, S., Hesham, H., & Mitchell, C.
- Affiliations
- Massachusetts General Hospital (US)
- Harvard University (US)
- Corresponding author
- Mitchell, Caroline
- Venue
- Microbial Pathogenesis
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 148
- Pages
- 104544
- ISSN
- 0882-4010 (ISSN-L)
- OpenAlex
- W3089340588
- Cited by
- 33
- References
- 2
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbial Pathogenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- lactobacilli, recurrent urinary tract infection, probiotics, uropathogens, Escherichia coli, antibiotic resistance, antibiotic prophylaxis, women's health
- MeSH terms
- Escherichia coli, Escherichia coli Infections, Female, Humans, Lactobacillus, Urinary Tract Infections, Probiotics
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