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The antitumor and antioxidative activities of polysaccharides isolated from Isaria farinosa B05
Open accessAbstract
The water-soluble intra-polysaccharides WIPS1 and water-soluble extra-polysaccharides WEPS1 were isolated from Isaria farinosa B05 through ethanol precipitation and gel permeation chromatography (GPC). Their characteristics were determined by chemical analysis, gas chromatography, GPC and IR spectroscopy. The results show that WIPS1 contained 90.3% carbohydrate, 8.00% uronic acid, 7.15% protein and three kinds of monosaccharides including mannose, galactose and glucose with a molar ratio of 8.0:4.8:1.0. WEPS1 contained 93.4% carbohydrate, 8.06% uronic acid, 4.40% protein and three kinds of monosaccharides including mannose, galactose and glucose with a molar ratio of 21.6:4.7:1.0. WIPS1 and WEPS1 had a molecular weight of 42 and 208kDa, respectively. The in vivo tests in mice indicate that WIPS1 and WEPS1 had significant antitumor and antioxidative activities to some extent.
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“Enhanced activities of superoxide dismutase, glutathione peroxidase and catalase in murine hepatocytes and erythrocytes, as well as decreased levels of malondialdehyde by EPS, have been reported [115,127,128].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [127]
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Metadata
- Authors
- Jiang, Y.-H., Jiang, X.-L., Wang, P., Mou, H.-J., Hu, X.-K., & Liu, S.-Q.
- Affiliations
- Ocean University of China (CN)
- ORCID
- Wang, Peng
- Venue
- Microbiological Research
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 163
- Issue
- 4
- Pages
- 424-430
- ISSN
- 0944-5013 (ISSN-L)
- OpenAlex
- W2071527686
- Cited by
- 41
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbiological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Keywords
- Isaria farinosa, fungal polysaccharides, anticancer activity, antioxidant activity, uronic acid, monosaccharide composition, molecular weight, chemoprevention
- MeSH terms
- Animals, Antineoplastic Agents, Antioxidants, Carbohydrates, Catalase, Chromatography, Gas, Chromatography, Gel, Female, Chemical Fractionation, Hypocreales, Liver, Molecular Weight, Polysaccharides, Proteins, Sarcoma, Superoxide Dismutase, Uronic Acids, Spectroscopy, Fourier Transform Infrared, Mice
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