CoChat
Sign Up
Cited by 44Antifungal resistance and susceptibilityGut microbiota and healthOral Health Pathology and Treatment

Is Candida albicans a contributor to cancer? A critical review based on the current evidence

Open access
Wang, Xu, Zhang, Wenqing, Wu, Wenjie, Wu, Shuangshuang, Young, Andrew, Yan, Zhimin·2023·Microbiological Research
DOI 10.1016/j.micres.2023.127370
Open this paper in CoChat — free account

Abstract

The association between Candida albicans (C. albicans) and cancer has been noticed for decades. Whether C. albicans infection is a complication of cancer status or as a contributor to cancer development remains to be discussed. This review systematically summarized the up-to-date knowledge about associations between C. albicans and various types of cancer, and discussed the role of C. albicans in cancer development. Most of the current clinical and animal evidence support the relationship between C. albicans and oral cancer development. However, there is insufficient evidence to demonstrate the role of C. albicans in other types of cancer. Moreover, this review explored the underlying mechanisms for C. albicans promoting cancer. It was hypothesized that C. albicans may promote cancer progression by producing carcinogenic metabolites, inducing chronic inflammation, remodeling immune microenvironment, activating pro-cancer signals, and synergizing with bacteria.

Integrity signals

Registry

Crossref · 10.1016/j.micres.2023.127370

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

The citation lists haven’t been fetched yet

References 203 · Cited by 44

Authors
Wang, X., Zhang, W., Wu, W., Wu, S., Young, A., & Yan, Z.
Affiliations
  • Peking University (CN)
  • University of the Pacific (US)
Corresponding author
Yan, Zhimin
ORCID
Venue
Microbiological Research
Publisher
Elsevier BV
Published
2023-07
Volume
272
Pages
127370
ISSN
0944-5013 (ISSN-L)
DOI
10.1016/j.micres.2023.127370
OpenAlex
W4361264290
Cited by
44
References
203
Citations by year
2026: 10 · 2025: 20 · 2024: 10 · 2023: 4
FWCI
2.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbiological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81570985, 82170967)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
Keywords
Candida albicans, oral cancer, carcinogenesis, chronic inflammation, tumor immune microenvironment, carcinogenic metabolites, tumor progression
MeSH terms
Animals, Candida albicans, Candidiasis, Inflammation, Neoplasms, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review