The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Structure of an Hsp90-Cdc37-Cdk4 Complex
Open accessAbstract
Activation of many protein kinases depends on their interaction with the Hsp90 molecular chaperone system. Recruitment of protein kinase clients to the Hsp90 chaperone system is mediated by the co-chaperone adaptor protein Cdc37, which acts as a scaffold, simultaneously binding protein kinases and Hsp90. We have now expressed and purified an Hsp90-Cdc37-Cdk4 complex, defined its stoichiometry, and determined its 3-dimensional structure by single-particle electron microscopy. Comparison with the crystal structure of Hsp90 allows us to identify the locations of Cdc37 and Cdk4 in the complex, and suggests a mechanism by which conformational changes in the kinase are coupled to the Hsp90 ATPase cycle.
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Cites
Roe, S. M., Prodromou, C., O'Brien, R., Ladbury, J. E., Piper, P. W., & Pearl, L. H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980403y · Cited by 1,004
Self-citationCrystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
Ali, M. M. U., Roe, S. M., Vaughan, C. K., Meyer, P., Panaretou, B., Piper, P. W., Prodromou, C., & Pearl, L. H. (2006) · Nature · doi:10.1038/nature04716 · Cited by 962 · cited 14×
“(Ali et al., 2006) was used to assign the hand of the EM map.”
BackgroundMethodResultInfluentialSelf-citationMeyer, P., Prodromou, C., Hu, B., Vaughan, C., Roe, S. M., Panaretou, B., Piper, P. W., & Pearl, L. H. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00065-0 · Cited by 491
Self-citationMammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
Stepanova, L., Leng, X., Parker, S. B., & Harper, J. W. (1996) · Genes & Development · doi:10.1101/gad.10.12.1491 · Cited by 483 · cited 4×
“…and Marsh, 2000; Xu and Lindquist, 1993; Xu et al., 1999), Aurora B (Lange et al., 2002), RIP (Lewis et al., 2000), components of the IkB kinase complex (Chen et al., 2002), and the cyclin-dependent kinases Cdk4, Cdk6, and Cdk9 (Mahony et al., 1998; O’Keeffe et al., 2000; Stepanova et al., 1996).”
BackgroundInfluentialHeat-shock protein hsp90 governs the activity of pp60v-src kinase.
Xu, Y., & Lindquist, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7074 · Cited by 416 · cited 1×
“…Raf-1 (Grammatikakis et al., 1999; Schulte et al., 1995; Stancato et al., 1993), ErbB2 (Xu et al., 2001), Src-family kinases (Bijlmakers and Marsh, 2000; Xu and Lindquist, 1993; Xu et al., 1999), Aurora B (Lange et al., 2002), RIP (Lewis et al., 2000), components of the IkB kinase complex (Chen et…”
BackgroundCo-chaperone regulation of conformational switching in the Hsp90 ATPase cycle
Siligardi, G., Hu, B., Panaretou, B., Piper, P. W., Pearl, L. H., & Prodromou, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410562200 · Cited by 207 · cited 1×
“Biochemical and structural data to date support an ATP-driven molecular clamp mechanism (Prodromou et al., 2000; Siligardi et al., 2004), and large conformational changes of the type described above are a prerequisite for this.”
BackgroundSelf-citation
Cited by
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Taipale, M., Jarosz, D. F., & Lindquist, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2918 · Cited by 1,818
Targeting the dynamic HSP90 complex in cancer
Trepel, J., Mollapour, M., Giaccone, G., & Neckers, L. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2887 · Cited by 1,514
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Taipale, M., Krykbaeva, I., Koeva, M., Kayatekin, C., Westover, K. D., Karras, G. I., & Lindquist, S. (2012) · Cell · doi:10.1016/j.cell.2012.06.047 · Cited by 879
Native mass spectrometry: a bridge between interactomics and structural biology
Heck, A. J. R. (2008) · Nature Methods · doi:10.1038/nmeth.1265 · Cited by 766
The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones
Li, J., Soroka, J., & Buchner, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.09.003 · Cited by 498
Metadata
- Authors
- Vaughan, C. K., Gohlke, U., Sobott, F., Good, V. M., Ali, M. M. U., Prodromou, C., Robinson, C. V., Saibil, H. R., & Pearl, L. H.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 23
- Issue
- 5
- Pages
- 697-707
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2098224915
- Cited by
- 293
- References
- 6
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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