The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Genome-Wide Replication-Independent Histone H3 Exchange Occurs Predominantly at Promoters and Implicates H3 K56 Acetylation and Asf1
Open accessAbstract
In yeast, histone H3/H4 exchange independent of replication is poorly understood. Here, we analyzed the deposition of histone H3 molecules, synthesized during G1, using a high-density microarray histone exchange assay. While we found that H3 exchange in coding regions requires high levels of transcription, promoters exchange H3 molecules in the absence of transcription. In inactive promoters, H3 is deposited predominantly in well-positioned nucleosomes surrounding nucleosome-free regions, indicating that some nucleosomes in promoters are dynamic. This could facilitate induction of repressed genes. Importantly, we show that histone H3 K56 acetylation, a replication-associated mark, is also present in replication-independent newly assembled nucleosomes and correlates perfectly with the deposition of new H3. Finally, we found that transcription-dependent incorporation of H3 at promoters is highly dependent on Asf1. Taken together, our data underline the dynamic nature of replication-independent nucleosome assembly/disassembly, specify a link to transcription, and implicate Asf1 and H3 K56 acetylation.
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“Histone chaperones and ATP-dependent chromatin-remodelling complexes are accordingly important for gene regulation given they regulate nucleosome dynamics at promoters, restricting or increasing promoter accessibility for recruitment of transcription factors and RNA polymerase II (Pol II)19–23.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [21]
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Cites
Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast
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Genome-Scale Identification of Nucleosome Positions in S. cerevisiae
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From Silencing to Gene Expression
Janicki, S. M., Tsukamoto, T., Salghetti, S. E., Tansey, W. P., Sachidanandam, R., Prasanth, K. V., Ried, T., Shav-Tal, Y., Bertrand, E., Singer, R. H., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00171-0 · Cited by 704
Histone Variant H2A.Z Marks the 5′ Ends of Both Active and Inactive Genes in Euchromatin
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Dynamics of Replication-Independent Histone Turnover in Budding Yeast
Dion, M. F., Kaplan, T., Kim, M., Buratowski, S., Friedman, N., & Rando, O. J. (2007) · Science · doi:10.1126/science.1134053 · Cited by 556
Zhang, H., Roberts, D. N., & Cairns, B. R. (2005) · Cell · doi:10.1016/j.cell.2005.08.036 · Cited by 545
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response
Masumoto, H., Hawke, D., Kobayashi, R., & Verreault, A. (2005) · Nature · doi:10.1038/nature03714 · Cited by 544
Genome-scale profiling of histone H3.3 replacement patterns
Mito, Y., Henikoff, J. G., & Henikoff, S. (2005) · Nature Genetics · doi:10.1038/ng1637 · Cited by 526
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Self-citationYeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56
Driscoll, R., Hudson, A., & Jackson, S. P. (2007) · Science · doi:10.1126/science.1135862 · Cited by 439
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Histone exchange, chromatin structure and the regulation of transcription
Venkatesh, S., & Workman, J. L. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3941 · Cited by 997
Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C
Hsieh, T.-H. S., Weiner, A., Lajoie, B., Dekker, J., Friedman, N., & Rando, O. J. (2015) · Cell · doi:10.1016/j.cell.2015.05.048 · Cited by 788
Post-Translational Modifications of Histones That Influence Nucleosome Dynamics
Bowman, G. D., & Poirier, M. G. (2014) · Chemical Reviews · doi:10.1021/cr500350x · Cited by 549
Signals and Combinatorial Functions of Histone Modifications
Suganuma, T., & Workman, J. L. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061809-175347 · Cited by 508
Neumann, H., Hancock, S. M., Buning, R., Routh, A. L., Chapman, L., Somers, J., Owen‐Hughes, T., van Noort, J., Rhodes, D., & Chin, J. W. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.027 · Cited by 498
Metadata
- Authors
- Rufiange, A., Jacques, P.-É., Bhat, W., Robert, F., & Nourani, A.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Montreal Clinical Research Institute (CA)
- Corresponding author
- Nourani, Amine
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 27
- Issue
- 3
- Pages
- 393-405
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1980716967
- Cited by
- 313
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 14 · 2022: 5 · 2021: 14 · 2020: 20 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 23 · 2014: 26 · 2013: 26 · 2012: 28
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- promoter, Asf1, nucleosome assembly, nucleosome dynamics, nucleosome-free regions, transcription, gene repression, Saccharomyces cerevisiae
- MeSH terms
- Acetylation, Chromatin, Cytosol, DNA Replication, HeLa Cells, Histones, Humans, Promoter Regions, Genetic, Protein Processing, Post-Translational, Saccharomyces cerevisiae, S Phase, Genome, Fungal, Cell Cycle Proteins, Molecular Chaperones, Saccharomyces cerevisiae Proteins, Chromatin Immunoprecipitation, Immunoprecipitation
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