Comprehensive Identification of PIP3-Regulated PH Domains from C. elegans to H. sapiens by Model Prediction and Live Imaging

Park, Wei Sun, Do Heo, Won, Whalen, James H., O'Rourke, Nancy A., Bryan, Heather M., Meyer, Tobias, Teruel, Mary N.·2008·Molecular Cell

Cited by (172)

Items 101–172 of 172

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  5. Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues
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  6. ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences
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  7. Genome-wide Structural Analysis Reveals Novel Membrane Binding Properties of AP180 N-terminal Homology (ANTH) Domains
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  9. Small chemicals with inhibitory effects on PtdIns(3,4,5)P3 binding of Btk PH domain
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  10. N‐terminal PH domain and C‐terminal auto‐inhibitory region of CKIP‐1 coordinate to determine its nucleus‐plasma membrane shuttling
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  15. Made to measure – keeping Rho kinase at a distance
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  16. Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate
    Shigeru Morimura, Katsuo Suzuki, Kazuhide Takahashi · 2010 · Biochemical and Biophysical Research Communications
  17. Phosphatidylinositol 3-Kinase-dependent Activation of Mammalian Protein Kinase B/Akt in Saccharomyces cerevisiae, an in Vivo Model for the Functional Study of Akt Mutations
    Isabel Rodríguez‐Escudero, Amparo Andrés‐Pons, Rafael Pulido, Marı́a Molina, Vı́ctor J. Cid · 2009 · Journal of Biological Chemistry
  18. Crosstalk between anti-angiogenic and pro-angiogenic pathways in disease: Mechanisms and therapeutic strategies
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  19. Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate
    Kazuhide Takahashi, Tacu Tanaka, Katsuo Suzuki · 2009 · Cellular Signalling
  20. Gradients of PI(4,5)P2 and PI(3,5)P2 Jointly Participate in Shaping the Back State of Dictyostelium Cells
    Dong Li, Feifei Sun, Yihong Yang, Hui Tu, Huaqing Cai · 2022 · Frontiers in Cell and Developmental Biology
  21. Novel protein Callipygian defines the back of migrating cells
    Kristen F. Swaney, Jane A. Borleis, Pablo A. Iglesias, Peter N. Devreotes · 2015 · Proceedings of the National Academy of Sciences
  22. Global approaches for the elucidation of phosphoinositide-binding proteins
    Michael D. Best · 2013 · Chemistry and Physics of Lipids
  23. WAVE2 Protein Complex Coupled to Membrane and Microtubules
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  24. A Systematic Screen for Protein-Lipid Interactions in Saccharomyces cerevisiae
    Oriol Gallego, C. Fernandez-Tornero, Carmen Aguilar‐Gurrieri, C. Muller, A.C. Gavin · 2010 · Worldwide Protein Data Bank
  25. Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy
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  27. PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans
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  28. PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
    Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia Angelova, Karoline Wenzl, Andreas Brandstätter et al. · 2025 · Proceedings of the National Academy of Sciences
  29. PI3Ks—Drug Targets in Inflammation and Cancer
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  31. WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2
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  32. Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease
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  33. Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
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  37. Lysosomal PIP 3 revealed by genetically encoded lipid biosensors
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  38. Inhibition of phosphatidylinositol-3,4,5-trisphosphate binding to the AKT pleckstrin homology domain by 4-amino-1,2,5-oxadiazole derivatives
    Sukhamoy Gorai, Saurav Sekhar Paul, S. Ganga, Rituparna Borah, Manas Kumar Santra, Debasis Manna · 2015 · MedChemComm
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    Robert R. Kay, Judith E. Lutton, Helena L.E. Coker, Peggy Paschke, Jason King, Till Bretschneider · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
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  41. Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experiments
    Yonghwan Kim, Youngdae Yoon · 2014 · Bioorganic & Medicinal Chemistry Letters
  42. Ligand-biased regulation of PtdIns(3,4,5)P3-dependent signal transduction in GPCR control of pituitary hormone release
    Joshua G. Pemberton, John Philip Chang · 2016 · Endocrinology
  43. Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3
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  44. Synthesis and Cellular Labeling of Multifunctional Phosphatidylinositol Bis‐ and Trisphosphate Derivatives
    Rainer Müller, Ana Kojic, Mevlut Citir, Carsten Schultz · 2021 · Angewandte Chemie
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    Steward Hadi, Leo Alberto Porjo, Ferry Sandra · 2022 · The Indonesian Biomedical Journal
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    Morten Källberg, Nitin Bhardwaj, Robert Ezra Langlois, Hui Juan Lu · 2012 · Bioinformatics
  47. Differential Activity of the KRAS Oncogene by Method of Activation: Implications for Signaling and Therapeutic Intervention
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  48. Single-Molecule Imaging and Super-Resolution Microscopy of Lipid Domains in Cell Membranes Using Lipid-Binding Proteins and Fluorophore-Conjugated Lipid Analogs
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  52. Regulation of PHLPP2 Expression in AML
    Kelly Mary Theede · 2012 · University of Minnesota Digital Conservancy (University of Minnesota)
  53. The Regulation of PREX2 by Phosphorylation
    Douglas Barrows · 2015
  54. Autophagic Dysfunction in Neurodegeneration
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  56. A functional proteomics approach to understanding the PI3K‐insulin signaling network in fat cells
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  57. Faculty Opinions recommendation of A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.
    Peter Mayinger · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  58. Faculty Opinions recommendation of Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly.
    Christel Depienne · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  59. Data from Ceramide Kinase Inhibition Drives Ferroptosis and Sensitivity to Cisplatin in Mutant KRAS Lung Cancer by Dysregulating VDAC-Mediated Mitochondria Function
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  60. WITHDRAWN: HER2 Cellular Localization, Cell-Cell Contacts, and Cell Density Regulate Cancer Cell Plasticity in HER2+ Breast Cancer
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  61. Additional file 1 of Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
    Bobae Hyeon, Heeyoung Lee, Nury Kim, Won Do Heo · 2024 · Figshare
  62. Additional file 2 of Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
    Bobae Hyeon, Lee, Heeyoung, Nury Kim, Won Do Heo · 2024 · Figshare
  63. Additional file 3 of Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
    Bobae Hyeon, Lee, Heeyoung, Nury Kim, Won Do Heo · 2024 · Figshare
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  68. Recognition of negative charge arrays by pleckstrin homology (PH) domains
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  70. BindingDB Entry 50044339: Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experiments.
    BindingDB · 2015 · UC San Diego
  71. BindingDB Entry 50033055: Development of sulfonamide AKT PH domain inhibitors.
    BindingDB · 2011 · UC San Diego
  72. BindingDB Entry 50044335: Small chemicals with inhibitory effects on PtdIns(3,4,5)P3 binding of Btk PH domain.
    BindingDB · 2015 · UC San Diego