Comprehensive Identification of PIP3-Regulated PH Domains from C. elegans to H. sapiens by Model Prediction and Live Imaging
Park, Wei Sun, Do Heo, Won, Whalen, James H., O'Rourke, Nancy A., Bryan, Heather M., Meyer, Tobias, Teruel, Mary N.·2008·Molecular Cell
Cited by (172)
Items 101–172 of 172
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- Membrane Docking Geometry of GRP1 PH Domain Bound to a Target Lipid Bilayer: An EPR Site-Directed Spin-Labeling and Relaxation StudyHuai-Chun Chen, Brian P. Ziemba, Kyle E. Landgraf, John Corbin, Joseph J. Falke · 2012 · PLoS ONE
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- Gradients of PI(4,5)P2 and PI(3,5)P2 Jointly Participate in Shaping the Back State of Dictyostelium CellsDong Li, Feifei Sun, Yihong Yang, Hui Tu, Huaqing Cai · 2022 · Frontiers in Cell and Developmental Biology
- Novel protein Callipygian defines the back of migrating cellsKristen F. Swaney, Jane A. Borleis, Pablo A. Iglesias, Peter N. Devreotes · 2015 · Proceedings of the National Academy of Sciences
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- A Systematic Screen for Protein-Lipid Interactions in Saccharomyces cerevisiaeOriol Gallego, C. Fernandez-Tornero, Carmen Aguilar‐Gurrieri, C. Muller, A.C. Gavin · 2010 · Worldwide Protein Data Bank
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- PHLPP phosphatases as a therapeutic target in insulin resistance-related diseasesMarta Letizia Hribal, Elettra Mancuso, Rosangela Spiga, Gaia Chiara Mannino, Teresa Vanessa Fiorentino, Francesco Andreozzi, Giorgio Sesti · 2015 · Expert Opinion on Therapeutic Targets
- PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegansSrinivas Ayyadevara, Meenakshisundaram Balasubramaniam, Jay E. Johnson, Ramani Alla, Samuel G. Mackintosh, Robert J. Shmookler Reis · 2016 · Oncotarget
- PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestorTarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia Angelova, Karoline Wenzl, Andreas Brandstätter et al. · 2025 · Proceedings of the National Academy of Sciences
- PI3Ks—Drug Targets in Inflammation and CancerMatthias P. Wymann · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
- Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) OncoproteinMarc Lenoir, Masae Sugawara, Jaswant Kaur, Linda Ball, Michael Overduin · 2014 · Journal of Biological Chemistry
- WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2Kazuhide Takahashi, Katsuo Suzuki · 2010 · Cellular Signalling
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver diseaseZhili Cheng, Magdalene K. Montgomery · 2025 · Clinical Science
- Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axonsBobae Hyeon, Hee‐Young Lee, Nury Kim, Won Do Heo · 2023 · Molecular Brain
- Emerging roles of PHLPP phosphatases in the nervous systemAyan Mallick, Medha Sharma, Chinmoy Sankar Dey · 2022 · Molecular and Cellular Neuroscience
- Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization ofDictyosteliummyosin 1sHanna Brzeska, Jesus Gonzalez, Edward D. Korn, Margaret A. Titus · 2019 · Molecular Biology of the Cell
- Single-molecule lipid biosensors mitigate inhibition of endogenous effector proteinsVictoria L. Holmes, Morgan M.C. Ricci, Claire C. Weckerly, Michael Worcester, Gerald R. V. Hammond · 2025 · The Journal of Cell Biology
- Lysosomal PIP 3 revealed by genetically encoded lipid biosensorsAyse Z. Sahan, Mingyuan Chen, Qi Su, Qingrong Li, Dong Wang, Jin Zhang · 2025 · Proceedings of the National Academy of Sciences
- Inhibition of phosphatidylinositol-3,4,5-trisphosphate binding to the AKT pleckstrin homology domain by 4-amino-1,2,5-oxadiazole derivativesSukhamoy Gorai, Saurav Sekhar Paul, S. Ganga, Rituparna Borah, Manas Kumar Santra, Debasis Manna · 2015 · MedChemComm
- The Amoebal Model for MacropinocytosisRobert R. Kay, Judith E. Lutton, Helena L.E. Coker, Peggy Paschke, Jason King, Till Bretschneider · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
- A PI(4,5)P2‐derived “gasoline engine model” for the sustained B cell receptor activationChenguang Xu, Zhengpeng Wan, Samina Shaheen, Jing Wang, Zhiyong Yang, Wanli Liu · 2019 · Immunological Reviews
- Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experimentsYonghwan Kim, Youngdae Yoon · 2014 · Bioorganic & Medicinal Chemistry Letters
- Ligand-biased regulation of PtdIns(3,4,5)P3-dependent signal transduction in GPCR control of pituitary hormone releaseJoshua G. Pemberton, John Philip Chang · 2016 · Endocrinology
- Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3Youjia Zhang, Liang Ge, Li Xu, Yongrui Liu, Jiarong Wang, Chongxu Liu, Hongxin Zhao, Lei Xing, Junfeng Wang, Bo Wu · 2023 · International Journal of Molecular Sciences
- Synthesis and Cellular Labeling of Multifunctional Phosphatidylinositol Bis‐ and Trisphosphate DerivativesRainer Müller, Ana Kojic, Mevlut Citir, Carsten Schultz · 2021 · Angewandte Chemie
- Mechanism and Potential Therapy in Ameloblastoma: Akt Signaling PathwaySteward Hadi, Leo Alberto Porjo, Ferry Sandra · 2022 · The Indonesian Biomedical Journal
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- Differential Activity of the KRAS Oncogene by Method of Activation: Implications for Signaling and Therapeutic InterventionNathan T. Ihle · 2012 · Digital Commons-TMC (Texas Medical Center)
- Single-Molecule Imaging and Super-Resolution Microscopy of Lipid Domains in Cell Membranes Using Lipid-Binding Proteins and Fluorophore-Conjugated Lipid AnalogsToshiki Mori, Kenichi G. N. Suzuki · 2025 · Membranes
- Proteomic and yeast 2-hybrid screens to identify PTEN binding partnersPriyanka Tibarewal, Laura Spinelli, Hélène Maccario, Nicholas R. Leslie · 2023 · Advances in Biological Regulation
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- Insights into the molecular regulatory mechanisms of tumor macropinocytosisChunlan Wang, Zihang Yuan, Bo Lin, Ziru Meng, Zhe Jin, Fei Yang, Hua Su · 2025 · Chinese Science Bulletin (Chinese Version)
- Regulation of PHLPP2 Expression in AMLKelly Mary Theede · 2012 · University of Minnesota Digital Conservancy (University of Minnesota)
- The Regulation of PREX2 by PhosphorylationDouglas Barrows · 2015
- Autophagic Dysfunction in NeurodegenerationMeenakshi Kaira, Abhilasha Ahlawat, Vaibhav Walia, Munish Garg · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
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- A functional proteomics approach to understanding the PI3K‐insulin signaling network in fat cellsMary N. Teruel · 2010 · The FASEB Journal
- Faculty Opinions recommendation of A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.Peter Mayinger · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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- WITHDRAWN: HER2 Cellular Localization, Cell-Cell Contacts, and Cell Density Regulate Cancer Cell Plasticity in HER2+ Breast CancerSaba Sameri, Durdam Das, Shabnam Shahrivari, Vladan Milosevic, Shamim Sarhadi, Huiqin Koerkel-Qu, Carolina Fisch, Miriam Kokal, Michael Schletter, Paul S. Hahn et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axonsBobae Hyeon, Heeyoung Lee, Nury Kim, Won Do Heo · 2024 · Figshare
- Additional file 2 of Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axonsBobae Hyeon, Lee, Heeyoung, Nury Kim, Won Do Heo · 2024 · Figshare
- Additional file 3 of Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axonsBobae Hyeon, Lee, Heeyoung, Nury Kim, Won Do Heo · 2024 · Figshare
- Rltpr, a lymphoid-specific protein essential for CD28 costimulationMargot Cucchetti · 2014 · theses.fr (ABES)
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- Recognition of negative charge arrays by pleckstrin homology (PH) domainsChristopher K Ng, James W. Murphy, Jeannine M. Mendrola, Michael Sarullo, Steven E. Stayrook, Kathryn M. Ferguson, Mark A. Lemmon · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- PI3K signaling in breast cancer: therapeutic advances versus adaptive resistanceFabiana Napolitano, Nisha G Unni, Carlos L. Arteaga · 2026 · Journal of Clinical Investigation
- BindingDB Entry 50044339: Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experiments.BindingDB · 2015 · UC San Diego
- BindingDB Entry 50033055: Development of sulfonamide AKT PH domain inhibitors.BindingDB · 2011 · UC San Diego
- BindingDB Entry 50044335: Small chemicals with inhibitory effects on PtdIns(3,4,5)P3 binding of Btk PH domain.BindingDB · 2015 · UC San Diego