Differential SUMOylation of LXRα and LXRβ Mediates Transrepression of STAT1 Inflammatory Signaling in IFN-γ-Stimulated Brain Astrocytes

Lee, Jee Hoon, Park, Sang Myun, Kim, Ohn Soon, Lee, Chang Seok, Woo, Joo Hong, Park, Soo Jung, Joe, Eun-hye, Jou, Ilo·2009·Molecular Cell
DOI 10.1016/j.molcel.2009.07.021

Cited by (145)

Items 101–145 of 145

  1. Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia
    Xiao He, Dayu Sun, Siyu Chen, Haiwei Xu · 2017 · OncoTarget
  2. Acetylation in Tumor Immune Evasion Regulation
    Jun Lu, Xiang He, Lijuan Zhang, Ran Zhang, Wenzheng Li · 2021 · Frontiers in Pharmacology
  3. Signal transducer and activator of transcription 1 (STAT1) acts like an oncogene in malignant pleural mesothelioma
    L. Arzt, Hannelore Kothmaier, I. Halbwedl, F. Quehenberger, H. Popper · 2014 · Virchows Archiv
  4. Exploring the Roles of Liver X Receptors in Lipid Metabolism and Immunity in Atherosclerosis
    Kaori Endo-Umeda, M. Makishima · 2025 · Biomolecules
  5. Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro.
    Limei Zhong, Quan Yang, Wen Xie, Jie Zhou · 2014 · Molecular Immunology
  6. Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes
    Hyunju Kang, Young-Ki Park, Ji-Young Lee, Minkyung Bae · 2024 · Diabetes & Metabolism Journal
  7. T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway
    Jia-Xing Dai, Shan-Cai Xu, Takeshi Okada, Yu Liu, Gang Zuo, Ji-Ping Tang, John H. Zhang, Huai-Zhang Shi · 2021 · Oxidative Medicine and Cellular Longevity
  8. Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner.
    J. Bogie, T. Vanmierlo, J. Vanmol, S. Timmermans, Jo Mailleux, Katherine Nelissen, E. Wijnands, K. Wouters, P. Stinissen, Jan-åke Gustafsson et al. · 2021 · Journal of Autoimmunity
  9. Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells[S]
    J. Lyu, H. Imachi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Toshihiro Kobayashi, Tao Dong, Takuo Yoshimoto, Kazuko Yonezaki, Hiromi Nagata et al. · 2018 · Journal of Lipid Research
  10. LXRα represses LPS-induced inflammatory responses by competing with IRF3 for GRIP1 in Kupffer cells.
    Chun-Lin Miao, K. He, Pei-zhi Li, Zuo-Jin Liu, Xi-Wen Zhu, Zhi-bing Ou, X. Ruan, J. Gong, Chang-An Liu · 2016 · International Immunopharmacology
  11. Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells.
    S. Nunomura, Y. Okayama, Kenji Matsumoto, N. Hashimoto, Kaori Endo-Umeda, T. Terui, M. Makishima, C. Ra · 2015 · Allergology International
  12. Lipid signaling in the atherogenesis context
    A. N. Smirnov · 2010 · Biochemistry (Moscow)
  13. Summon SUMO to wrestle with inflammation.
    Bin Liu, K. Shuai · 2009 · Molecules and Cells
  14. SUMOtherapeutics for Ischemic Stroke
    P. Karandikar, Jakob V. E. Gerstl, A. Kappel, S. Won, Daniel Dubinski, M. E. Garcia-Segura, F. Gessler, A. See, L. Peruzzotti-Jametti, J. Bernstock · 2023 · Pharmaceuticals
  15. Lipid metabolic reprogramming in immune regulation and chronic inflammatory diseases
    Ayaka Ito · 2025 · Endocrine journal
  16. IFN‐γ aggravates neointimal hyperplasia by inducing endoplasmic reticulum stress and apoptosis in macrophages by promoting ubiquitin‐dependent liver X receptor‐α degradation
    Qiang Zhao, Dong Zhou, Hongjun You, B. Lou, Yan Zhang, Yu-Ling Tian, Ning Guo, Xiaoli Chen, Yan Liu, Yuehua Wu et al. · 2017 · The FASEB Journal
  17. Up-Regulation of HDAC4 is Associated with Schwann Cell Proliferation After Sciatic Nerve Crush
    Yonghua Liu, Yang Liu, Xiaoke Nie, Jian-Hua Cao, Xiao-Jian Zhu, Weidong Zhang, Zhong-Bing Liu, X. Mao, Shi-Xian Yan, Ying-Jie Ni et al. · 2014 · Neurochemical Research
  18. Protein Kinase C Is Involved in the Induction of ATP‐Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages
    E. Huwait, N. Singh, D. Michael, T. Davies, J. W. E. Moss, D. Ramji · 2015 · Journal of Cellular Biochemistry
  19. LXR-β regulates microglial efferocytosis and neuroinflammation in CPSP via STAT6 activation.
    Hu Zang, Yingjie Hu, Xiaoyu Ji, Yuye Chen, Xiao He, Li Wan, Wen-Long Yao, Chuan-Han Zhang, Chang Zhu, Tongtong Liu · 2025 · Brain, behavior, and immunity
  20. Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity
    Mahsa Eskandari, A. Mellati · 2021 · Advanced Pharmaceutical Bulletin
  21. Type II nuclear receptors with potential role in Alzheimer disease
    Jonathan Muñoz-Cabrera, Sandoval-Hernández Adrián, Gonzalo Arboleda · 2021 · Molecular Aspects of Medicine
  22. Interferon‐γ decreases ATP‐binding cassette subfamily G member 1‐mediated cholesterol efflux through small ubiquitin‐like modifier/ubiquitin‐dependent liver X receptor‐α degradation in macrophages
    M. Dong, Yan Zhang, C. Xu, C. Wang, Mengping Liu, Zhanyi Zhang, Hao-Yu Wu, Z. Yuan, Juan Zhou · 2020 · Biotechnology and applied biochemistry
  23. Human hippocampal astrocytes: Computational dissection of their transcriptome, sexual differences and exosomes across ageing and mild‐cognitive impairment
    Daniel V. Guebel · 2023 · European Journal of Neuroscience
  24. Differential effects of and mechanisms underlying the protection of cardiomyocytes by liver-X-receptor subtypes against high glucose stress-induced injury.
    Qing He, Feng-Dan Wang, Yuqi Fan, Changqian Wang, Junfeng Zhang · 2018 · Biochemical and Biophysical Research Communications - BBRC
  25. LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells
    Yating Li, Chang-Wen Jing, Xin-Yi Tang, Yuan-Yuan Chen, Xiao Han, Yun-Xia Zhu · 2016 · Endocrine
  26. Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice
    Yawen Li, Hui Wang, Dongyuan Zhang, Shiqi Wang, Zheng Li, Jing-Jie Li, Shentao Tai, Dan-Dan Tong, Bifeng Wang, Dingbing Lu et al. · 2026 · Nature Communications
  27. Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas
    G. R. de Sousa, K. B. Salomão, L. F. Nagano, K. Riemondy, P. F. Chagas, L. Veronez, F. Saggioro, Suely K. N. Marie, J. Yunes, I. Cardinalli et al. · 2023 · Cancer Gene Therapy
  28. Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function
    Lucas T. Jennelle, Aditya P. Dandekar, Tshifhiwa Magoro, Y. Hahn · 2016 · Critical Reviews in Immunology
  29. Physiological activation of liver X receptor provides protection against ocular inflammation in uveitic glaucoma
    Hyun-hee Ju, Jiyoung Lee, Seon-Kyu Kim, Seon-Young Kim, Jin-Hyun Ahn, Nikolai P. Skiba, P. V. Rao, Jin A. Choi · 2024 · Biochimica et Biophysica Acta - Molecular Basis of Disease
  30. Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
    Jasminka Štefulj, Ute Panzenboeck, Patrick R. Hof, Goran Šimić · 2013 · Translational Neuroscience
  31. Liver X receptor α contribution to neuroinflammation and glial cells activation induced by MPTP: Implications for Parkinson’s disease
    Zhihao Mao, Yuning Zhang, Yirong Liang, Chenglai Xia, Lan Tang · 2024 · Neuroscience
  32. Regulatory mechanism underlying liver X receptor effects on the tumor microenvironment, inflammation and tumorigenesis
    Heng Zhang, Jing Wang, Jian Sun, Qiang Wang, Lanfang Guo, Xiao-Li Ju · 2023 · Expert opinion on therapeutic targets
  33. PIAS1-mediated GSK3β SUMOylation exacerbates tauopathy and cognitive deficits in Alzheimer’s disease models
    You-Lan Qiu, Suo-Fu Wu, Yi Zhong, Di Fan, Q. Tong, Jing Xiong, Kun Xu, Gang Liu, En-Jie Liu, Xiao-Guang Li et al. · 2026 · Molecular Psychiatry
  34. HDAC7 acts as an astrocytic mediator of Aβ pathology that directly engages IKK to drive astrocyte neurotoxicity and neurodegeneration in Alzheimer’s disease
    Jinwang Ye, Yunsong Deng, Bingge Zhang, Chengjia Li, Xing Guo, Ruizhu Yue, Huali Wan, Yue Hao, Shifeng Xiao · 2026 · Alzheimer s Research & Therapy
  35. SUMOylation in Neural Health and Disease: From Cellular Homeostasis to Neurodegeneration
    G. Oriquat, I. Jasim, Tushar B. Gajjar, M. Hanumanthayya, Israa Abdulhameed Ahmad, Gunjan Singh, L. Maharana, Neeraj Bainsal · 2026 · DNA and Cell Biology
  36. Astrocyte regulates neuroinflammation and myelination in BCCAO-Related cognitive impairment via the PIAS1-STAT1 pathway.
    Hao Ding, Shuo Wu, Dongya Huang, Lianbiao Shan · 2025 · Brain Research
  37. The sterols–LXR axis alleviates IL-17-mediated acute inflammatory response in Apostichopus japonicus
    Si Zhu, Zhimeng Lv, Ji-Qing Liu, Yanrong Li, Cheng-Hua Li · 2025 · Marine Life Science & Technology
  38. THE ROLE OF PXR AND IKKβ SIGNALING IN CARDIOMETABOLIC DISEASE
    Robert Nathaniel Helsley · 2016 · UKnowledge (University of Kentucky)
  39. An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer
    Cheng, Chun, Sun, Longhua, Yang, Jiaxue, Liu, Zhiliang, Zhang, Fan, Qiu, Lingyan, Yu, Meng, Wang, Ting, Huang, Jianxin, Wang, Li et al. · 2026 · Nature Communications
  40. ApoE-Dependent Lipid Handling by Median Eminence Microglia Preserves Myelin Integrity and Metabolic Function
    E. McGrath, A. Folick, LJ Morrissette, SM Brown Mayfield, V. Pham, SN Pillutla, Matthew Choi, RT Cheang, W. Bolus, A. Schwendeman et al. · 2026 · bioRxiv
  41. LXR-GDF15 activation Drives Profibrotic Changes in the Aqueous Outflow Tract of Uveitic Glaucoma.
    Hyun-hee Ju, Jiyoung Lee, Seon-Kyu Kim, Seon-Young Kim, Jin-Hyun Ahn, Nikolai Skiba, Vasantha Rao, Jin A. Choi · 2025 · American Journal of Pathology
  42. Specificity protein 1 induces the expression of angiomotin in response to IL-6/STAT3 activation to mediate YAP-dependent growth of breast cancer cells
    Lauren R. Bringman · 2016
  43. Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
    Simon Ducheix · 2013
  44. Mecanismes de control negatiu de la inflamació vehiculats per receptors nuclears
    Jonathan Matalonga Borrel, Annabel F. Valledor · 2014 · Treballs de la Societat Catalana de Biologia
  45. 14-3-3 sigma interacts with liver X receptor beta
    E. A. Jackson · 2010