Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

Goentoro, Lea; Kirschner, Marc W.

doi:10.1016/j.molcel.2009.11.017

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

SUMMARY In the canonical Wnt pathway, binding of the Wnt ligand to its transmembrane receptors leads to an inhibition of the degradation of β-catenin; as a result, β-catenin accumulates to a point where it activates target genes. Using mathematical modeling and experiments in mammalian cells, we …