The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling
Open accessAbstract
After termination, eukaryotic 80S ribosomes remain associated with mRNA, P-site deacylated tRNA and release factor eRF1, and must be recycled by dissociating these ligands and separating ribosomes into subunits. Although recycling of eukaryotic post-termination complexes (post-TCs) can be mediated by initiation factors eIF3, eIF1 and eIF1A (Pisarev et al., 2007), this energy-free mechanism can function only in a narrow range of low Mg2+ concentrations. Here we report that ABCE1, a conserved and essential member of the ATP-binding cassette (ABC) family of proteins, promotes eukaryotic ribosomal recycling over a wide range of Mg2+ concentrations. ABCE1 dissociates post-TCs into free 60S subunits and mRNA- and tRNA-bound 40S subunits. It can hydrolyze ATP, GTP, UTP and CTP. NTP hydrolysis by ABCE1 is stimulated by post-TCs and is required for its recycling activity. Importantly, ABCE1 dissociates only post-TCs obtained with eRF1/eRF3 (or eRF1 alone), but not post-TCs obtained with puromycin in eRF1's absence.
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Cites
Global analysis of protein expression in yeast
Ghaemmaghami, S., Huh, W.-K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., & Weissman, J. S. (2003) · Nature · doi:10.1038/nature02046 · Cited by 3,750
Cited by
NMD: a multifaceted response to premature translational termination
Kervestin, S., & Jacobson, A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3454 · Cited by 572
Pisareva, V. P., Skabkin, M. A., Hellen, C. U. T., Pestova, T. V., & Pisarev, A. V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.93 · Cited by 296
Self-citationKumar, P., Sweeney, T. R., Skabkin, M. A., Skabkina, O. V., Hellen, C. U. T., & Pestova, T. V. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1321 · Cited by 210
Self-citationHow HIV-1 Gag assembles in cells: Putting together pieces of the puzzle
Lingappa, J. R., Reed, J. C., Tanaka, M., Chutiraka, K., & Robinson, B. A. (2014) · Virus Research · doi:10.1016/j.virusres.2014.07.001 · Cited by 91
Metadata
- Authors
- Pisarev, A. V., Skabkin, M. A., Pisareva, V. P., Skabkina, O. V., Rakotondrafara, A. M., Hentze, M. W., Hellen, C. U. T., & Pestova, T. V.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 37
- Issue
- 2
- Pages
- 196-210
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1993969571
- Cited by
- 353
- References
- 1
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pisarev, A. V., Skabkin, M. A., Pisareva, V. P., Skabkina, O. V., Rakotondrafara, A. M., Hentze, M. W., Hellen, C. U. T., & Pestova, T. V. (2010). The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.12.034
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