Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione

Bien, Melanie, Longen, Sebastian, Wagener, Nikola, Chwalla, Ilona, Herrmann, Johannes M., Riemer, Jan·2010·Molecular Cell

Cited by (179)

Items 101–179 of 179

  1. Redox meets protein trafficking
    Bettina Bölter, Jürgen Soll, Serena Schwenkert · 2015 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  2. Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System
    Hatice Kubra Ozer, Adrienne C. Dlouhy, Jeremy D. Thornton, Jingjing Hu, Yilin Liu, Joseph J. Barycki, Janneke Balk, Caryn E. Outten · 2015 · Journal of Biological Chemistry
  3. Maintenance of small molecule redox homeostasis in mitochondria
    Lianne Jacobs, J. Riemer · 2022 · FEBS Letters
  4. Folding and Biogenesis of Mitochondrial Small Tim Proteins
    Efrain Ceh‐Pavia, Michael P. Spiller, Hui Lu · 2013 · International Journal of Molecular Sciences
  5. Protein import by the mitochondrial disulfide relay in higher eukaryotes
    Yannik Finger, Jan Riemer · 2020 · Biological Chemistry
  6. Mia40 Combines Thiol Oxidase and Disulfide Isomerase Activity to Efficiently Catalyze Oxidative Folding in Mitochondria
    Johanna R. Koch, Franz Xaver Schmid · 2014 · Journal of Molecular Biology
  7. The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo
    Alican J. Erdogan, Muna Ali, Markus Habich, Silja Lucia Salscheider, Laura Schu, Carmelina Petrungaro, Luke W. Thomas, Margaret A. Ashcroft, Lars Ingo Ole Leichert, Letícia Prates Roma et al. · 2018 · Redox Biology
  8. A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes
    Samantha Ebersoll, Blessing Musunda, Torsten Schmenger, Natalie Dirdjaja, Mariana Bonilla, Bruno Manta, Kathrin Ulrich, Marcelo Alberto Comini, R. Luise Krauth‐Siegel · 2018 · Redox Biology
  9. An Intrinsically Disordered Domain Has a Dual Function Coupled to Compartment-Dependent Redox Control
    Lucia Banci, Ivano Bertini, Chiara Cefaro, Simone Ciofi‐Baffoni, Karolina Gajda, Isabella C. Felli, Angelo Gallo, Anna Pavelkova, Emmanouela Kallergi, Maria Andreadaki et al. · 2012 · Journal of Molecular Biology
  10. Augmenter of liver regeneration: A key protein in liver regeneration and pathophysiology
    Parul Gupta, Senthil Kumar Venugopal · 2018 · Hepatology Research
  11. The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import
    Lena Maria Murschall, Anne Gerhards, Thomas MacVicar, Esra Peker, Lidwina Hasberg, Stephan Wawra, Thomas Langer, Jan Riemer · 2020 · BMC Biology
  12. Protein oxidation in the intermembrane space of mitochondria is substrate-specific rather than general
    Valentina Peleh, Jan Riemer, Andrew Dancis, Johannes M. Herrmann · 2014 · Microbial Cell
  13. Disulfide driven folding for a conditionally disordered protein
    Hugo Fraga, Jordi Pujols, Marcos Gil-García, Alicia Roque, Ganeko Bernardo‐Seisdedos, Carlo Santambrogio, Joan Josep Bech‐Serra, Françesc Canals, Pau Bernadó, Rita Grandori et al. · 2017 · Scientific Reports
  14. Mitochondrial protein homeostasis
    Aksana Varabyova, Diana Stojanovski, Agnieszka Chacińska · 2013 · IUBMB Life
  15. Oxidation and Reduction of Cysteines in the Intermembrane Space of Mitochondria: Multiple Facets of Redox Control
    Johannes M. Herrmann, Jan Riemer · 2010 · Antioxidants and Redox Signaling
  16. Biogenesis of yeast M ia40 – uncoupling folding from import and atypical recognition features
    Afroditi Chatzi, Dionisia P. Sideris, Nitsa Katrakili, Charalambos Pozidis, Kostas Tokatlidis · 2013 · FEBS Journal
  17. The Mitochondrial Intermembrane Space Oxireductase Mia40 Funnels the Oxidative Folding Pathway of the Cytochrome c Oxidase Assembly Protein Cox19
    Hugo Fraga, Joan Josep Bech‐Serra, Françesc Canals, Gabriel Ortega, Óscar Millet, Salvador Ventura · 2014 · Journal of Biological Chemistry
  18. The disease-associated mutation of the mitochondrial thiol oxidase Erv1 impairs cofactor binding during its catalytic reaction
    Efrain Ceh‐Pavia, Swee Kim Ang, Michael P. Spiller, Hui Lu · 2014 · Biochemical Journal
  19. Glutathione and glutathione-dependent enzymes
    Marcel Deponte · 2022 · Elsevier eBooks
  20. Experimental Approaches for Investigating Disulfide-Based Redox Relays in Cells
    James D. West · 2022 · Chemical Research in Toxicology
  21. Mitochondrial thiol oxidase Erv1: both shuttle cysteine residues are required for its function with distinct roles
    Swee Kim Ang, Mengqi Zhang, Tiziana Lodi, Hui Lu · 2014 · Biochemical Journal
  22. Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway
    Sonya E. Neal, Deepa V. Dabir, Heather L. Tienson, Darryl M. Horn, Kathrin Glaeser, Rachel R. Ogorzalek Loo, Antoni Barrientos, Carla M. Koehler · 2015 · Journal of Biological Chemistry
  23. Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space
    Phanee Manganas, Lisa MacPherson, Kostas Tokatlidis · 2016 · Cell and Tissue Research
  24. Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity
    Devin A. Hudson, Colin Thorpe · 2015 · Archives of Biochemistry and Biophysics
  25. CHCHD4 (MIA40) and the mitochondrial disulfide relay system.
    Hasan Al-Habib, Margaret A. Ashcroft · 2021 · Apollo (University of Cambridge)
  26. S-Glutathionylation of mouse selenoprotein W prevents oxidative stress-induced cell death by blocking the formation of an intramolecular disulfide bond
    Kwan Young Ko, Jea Hwang Lee, Jun Ki Jang, Yunjung Jin, Hyunwoo Kang, Ick Young Kim · 2019 · Free Radical Biology and Medicine
  27. The ins and outs of the intermembrane space: Diverse mechanisms and evolutionary rewiring of mitochondrial protein import routes
    Victoria L. Hewitt, Kipros Gabriel, Ana Traven · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
  28. Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy
    Ava Liaghati, Chantal A. Pileggi, Gaganvir Parmar, David A. Patten, Nina Hadžimustafić, Alexanne Cuillerier, Keir J. Menzies, Yan Burelle, Mary‐Ellen Harper · 2021 · Frontiers in Physiology
  29. Kinetic characterisation of Erv1, a key component for protein import and folding in yeast mitochondria
    Xiaofan Tang, Swee Kim Ang, Efrain Ceh‐Pavia, Derren J. Heyes, Hui Lu · 2019 · FEBS Journal
  30. Mitochondrial protein import machinery conveys stress signals to the cytosol and beyond
    Eirini Lionaki, Ilias Gkikas, Nektarios Tavernarakis · 2023 · BioEssays
  31. Gfer is a critical regulator of HSC proliferation
    Uma Sankar, Anthony R. Means · 2011 · Cell Cycle
  32. A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast
    Sandra Specht, Linda Liedgens, Margarida Duarte, Alexandra Stiegler, Ulrike Wirth, Maike Eberhardt, Ana M. Tomás, Kai Hell, Marcel Deponte · 2017 · Redox Biology
  33. Development of the Mitochondrial Intermembrane Space Disulfide Relay Represents a Critical Step in Eukaryotic Evolution
    Sandra Backes, Sriram G. Garg, Laura Becker, Valentina Peleh, Rudi Glockshuber, Sven B. Gould, Johannes M. Herrmann · 2019 · Molecular Biology and Evolution
  34. Erv1 and Cytochrome c Mediate Rapid Electron Transfer via A Collision-Type Interaction
    Esra Peker, Alican J. Erdogan, Alexander N. Volkov, Jan Riemer · 2021 · Journal of Molecular Biology
  35. The essential cysteines in the CIPC motif of the thioredoxin-like Trypanosoma brucei MICOS subunit TbMic20 do not form an intramolecular disulfide bridge in vivo
    Iosif Kaurov, Jiří Heller, Sebastian Deisenhammer, David Potěšil, Zbyněk Zdráhal, Hassan Hashimi · 2022 · Molecular and Biochemical Parasitology
  36. Privileged proteins with a second residence: dual targeting and conditional re‐routing of mitochondrial proteins
    Ophry Pines, M. J. Horwitz, Johannes M. Herrmann · 2024 · FEBS Journal
  37. Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation
    Robin Alexander Rothemann, Dylan Stobbe, Michaela Nicole Hoehne, Lena Maria Murschall, Esra Peker, Lara Katharina Knaup, Julia Racho, Markus Habich, Sarah Gerlich, Kim Jasmin Lapacz et al. · 2024 · FEBS Journal
  38. In Vivo Structure-Function Analysis and Redox Interactomes of Leishmania tarentolae Erv
    Gino L. Turra, Linda Liedgens, Frederik Sommer, Luzia Schneider, David M. Zimmer, Jordi Vilurbina Perez, Saša Končarević, Michael Schroda, Timo Mühlhaus, Marcel Deponte · 2021 · Microbiology Spectrum
  39. Oxidative Folding in the Mitochondrial Intermembrane Space in Human Health and Disease
    Hugo Fraga, Salvador Ventura · 2013 · International Journal of Molecular Sciences
  40. From Biogenesis to Breakdown: How Protein Biogenesis and Quality Control Failures Drive Mitochondrial Disease
    Phoebe J. Leeming, Julia Mercuri-Svik, Diana Stojanovski · 2025 · Molecular and Cellular Biology
  41. Common Players in Mitochondria Biogenesis and Neuronal Protection Against Stress-Induced Apoptosis
    Emmanouela Kallergi, Ester Kalef-Ezra, Katerina Dalakoura-Karagkouni, Kostas Tokatlidis · 2013 · Neurochemical Research
  42. Mechanisms and physiological impact of the dual localization of mitochondrial intermembrane space proteins
    Carmelina Petrungaro, Jan Riemer · 2014 · Biochemical Society Transactions
  43. Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control
    Danyun Zhang, Owen R. Dailey, Daniel J. Simon, Kamilah Roca-Datzer, Yasaman Jami‐Alahmadi, Mikayla S. Hennen, James Akira Wohlschlegel, Carla M. Koehler, Deepa V. Dabir · 2021 · Journal of Biological Chemistry
  44. The mitochondrial intermembrane space – a permanently proteostasis-challenged compartment
    Matthias Weith, Konstantin Weiss, Dylan Stobbe, Jan Riemer · 2025 · Biological Chemistry
  45. Redox characterisation of Erv1, a key component for protein import and folding in yeast mitochondria
    Efrain Ceh‐Pavia, Xiaofan Tang, Yawen Liu, Derren J. Heyes, Bing Zhao, Ping Xiao, Hui Lu · 2019 · FEBS Journal
  46. 3-mercaptopyruvate sulfurtransferase resides on the inner mitochondrial membrane
    Antonia Katsouda, Eleni Vasilaki, M. Fountoulakis, Ioanna Tremi, Sophia Havaki, Vassilios Myrianthopoulos, Vassilis G. Gorgoulis, Emmanuel Mikros, Andreas Papapetropoulos · 2025 · Nitric Oxide
  47. Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation
    Yaschar Kabiri, Anna Fuhrmann, Anna Becker, Luisa Jedermann, Carola Eberhagen, Ann‐Christine König, Tiago Silva, Fernanda Borges, Stefanie M. Hauck, Bernhard Michalke et al. · 2021 · Frontiers in Cell and Developmental Biology
  48. CHCHD4 Oxidoreductase Activity: A Comprehensive Analysis of the Molecular, Functional, and Structural Properties of Its Redox-Regulated Substrates
    Nicole Balasco, Nazanine Modjtahedi, Alessandra Monti, Menotti Ruvo, Luigi Vitagliano, Nunzianna Doti · 2025 · Molecules
  49. The mitochondrial disulphide relay substrate FAM136A safeguards IMS proteostasis and cellular fitness
    Christine Zarges, Hanna Fieler, Robin Alexander Rothemann, Simon Poepsel, Lucas T. Jae, Jan Riemer · 2025 · Redox Biology
  50. Enzymatic improvement of mitochondrial thiol oxidase Erv1 for oxidized glutathione fermentation by Saccharomyces cerevisiae
    Jyumpei Kobayashi, Daisuke Sasaki, Kiyotaka Y. Hara, Tomohisa Hasunuma, Akihiko Kondo · 2017 · Microbial Cell Factories
  51. Advances in nanomedicine strategies for modulating the tumor microenvironment: Recent progress and clinical perspectives
    Talha Bin Emran, Md. Al Amin, Safia Obaidur Rab, Patibandla Jahnavi, Rajeshwar Vodeti, Jeetendra Kumar Gupta, Uppuluri Varuna Naga Venkata Arjun, T. N. Umamaheswari, P. Balaji, Girija Dayalan et al. · 2025 · 3 Biotech
  52. In and out of the mitochondrial intermembrane space
    Fara van der Schans, Kostas Tokatlidis, Daniela G. Vitali · 2026 · Protein Science
  53. Compartmentalized disulfide bond formation pathways
    Konstantin Weiss, Julia Racho, Jan Riemer · 2022 · Elsevier eBooks
  54. Expression and copper binding studies of a Plasmodium falciparum protein with Cox19 copper binding motifs
    Abdulmalik Abdullahi Salman, J. P. Dean Goldring · 2023 · Experimental Parasitology
  55. MIA40 circumvents the folding constraints imposed by TRIAP1 function
    Jordi Pujols, Marc Fornt‐Suñé, Marcos Gil-García, Andrea Bartolomé-Nafría, Françesc Canals, Linda Cerofolini, Kaare Teilum, Lucia Banci, Sebastián Esperante, Salvador Ventura · 2025 · Journal of Biological Chemistry
  56. Oxidative folding: recent developments
    András Szarka, Gábor Bánhegyi · 2011 · BioMolecular Concepts
  57. The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease
    Yuan Dong, Yuejie Zhang, Yingmei Feng, Wei An · 2022 · Frontiers in Pharmacology
  58. A Thioredoxin reductive mechanism balances the oxidative protein import pathway in the intermembrane space of mitochondria
    Mauricio Cardenas‐Rodriguez, Phanee Manganas, Emmanouela Kallergi, Ruairidh Edwards, Afroditi Chatzi, Erik Lacko, Kostas Tokatlidis · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Role of tryptophan residues of Erv1: Trp95 and Trp183 are important for its folding and oxidase function
    Qi Wang, Swee Kim Ang, Efrain Ceh‐Pavia, Jiayun Pang, Hui Lu · 2015 · Bioscience Reports
  60. Redox signals and oxidative stress in the control of mitochondrial protein import
    Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer · 2026 · Protein Science
  61. The Interaction and Effect of a Small MitoBlock Library as Inhibitor of ALR Protein–Protein Interaction Pathway
    Riccardo Muzzioli, Angelo Gallo · 2024 · International Journal of Molecular Sciences
  62. Oxidation of Arabidopsis thaliana COX19 Using the Combined Action of ERV1 and Glutathione
    Flavien Zannini, Johannes M. Herrmann, Jérémy Couturier, Nicolas Rouhier · 2023 · Antioxidants
  63. Viaje al centro de la mitocondria: importación de proteínas, sus alteraciones y enfermedades relacionadas
    Maria Clara Avendaño‐Monsalve, José Carlos Ponce‐Rojas, Soledad Funes · 2021 · TIP Revista Especializada en Ciencias Químico-Biológicas
  64. Discovery of oxidative enzymes for food engineering : Tyrosinase and sulfhydryl oxidase
    Greta Faccio · 2011 · Työväentutkimus Vuosikirja
  65. Functional characterization of MCJ in the protein import into human mitochondria
    Christina Schusdziarra · 2014 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
  66. Oxidative Protein Folding
    Alexandra Gennaris, Jean‐François Collet · 2012 · Encyclopedia of Life Sciences
  67. The membrane potential is a key regulator for oxidation-dependent protein import into the mitochondrial inter membrane space (IMS)
    Manuel Fischer, Jan Riemer · 2012 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  68. Oxidation-driven protein import into the intermembrane space of mitochondria
    Johannes M. Herrmann, Daniel Weckbecker, Sebastian Longen, Jan Riemer · 2012 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  69. Functional and structural studies of the Presequence protease, PreP
    Hans G. Bäckman · 2014 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  70. Involvement of deafness dystonia protein 1 in the pathomechanism of deafness-dystonia-optic neuronopathy syndrome
    Gertraud Engl · 2012
  71. Caracterização funcional da peroxirredoxina mitocondrial (Prx1) na fisiologia redox de Saccharomyces cerevisiae
    Fernando Gomes · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  72. Investigating the Role of ROMO1 in Mitochondrial Protein Import and Inner Membrane Morphology
    Frank Richter · 2018
  73. Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19.
    Abdumalik Abdullahi. Salman · 2018 · ResearchSpace (University of KwaZulu-Natal)
  74. Approaches for the analysis of redox-dependent protein import into mitochondria of mammalian cells
    Julia Racho, Jan Riemer · 2024 · Methods in enzymology on CD-ROM/Methods in enzymology
  75. Analysis of targeting signals for mitochondrial intermembrane space import
    Kostas Tokatlidis, Amiyo Haider · 2024 · Methods in enzymology on CD-ROM/Methods in enzymology
  76. Analyse fonctionnelle de protéines métal- ou redox- dépendantes chez les plantes
    Flavien Zannini · 2019
  77. Mechanisms and pathways of protein oxidative folding
    Sebastián Esperante, Salvador Ventura · 2026 · Elsevier eBooks
  78. ALR couples IMS redox and heme biosynthesis beyond the disulfide relay
    Julia Racho, Dylan Stobbe, Jan Jirschitzka, Marijana Croon, Carmelina Petrungaro, Muna Ali, Dario Wernet, Markus Habich, Nele Sophie Gawellek, Julian Strippel et al. · 2026 · Science Advances
  79. Import of Presequence-Containing Precursor Proteins into Mitochondria
    Jonathan Melin · 2014