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The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation
Open accessAbstract
SUMMARY We demonstrate that RING finger protein MSL2 in the MOF-MSL complex is a histone ubiquitin E3 ligase. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail. H2B K34ub by MSL1/2 directly regulates H3 K4 and K79 methylation through trans-tail crosstalk both in vitro and in cells. The significance of MSL1/2 mediated histone H2B ubiquitylation is underscored by facts that MSL1/2 activity is important for transcription activation at HOXA9 and MEIS1 loci and that this activity is evolutionarily conserved in the Drosophila dosage compensation complex. Altogether, these results establish that the MOF-MSL complex possesses two distinct chromatin-modifying activities (i.e. H4 K16 acetylation and H2B K34 ubiquitylation) through MOF and MSL2 subunits. They also shed new lights on how intricate network of chromatin modifying enzymes functions coordinately in gene activation.
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Cites
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
McGinty, R. K., Kim, J., Chatterjee, C., Roeder, R. G., & Muir, T. W. (2008) · Nature · doi:10.1038/nature06906 · Cited by 563
Cited by
Quantitative Proteomic Analysis of Histone Modifications
Huang, H., Lin, S., Garcia, B. A., & Zhao, Y. (2015) · Chemical Reviews · doi:10.1021/cr500491u · Cited by 370
Self-citationFelix Sahayaraj, A., Joy Prabu, H., Maniraj, J., Kannan, M., Bharathi, M., Diwahar, P., & Salamon, J. (2023) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-023-02657-1 · Cited by 267
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
Kim, W., Choi, M., & Kim, J.-E. (2014) · Cell Cycle · doi:10.4161/cc.28104 · Cited by 121
Fuchs, G., Hollander, D., Voichek, Y., Ast, G., & Oren, M. (2014) · Genome Research · doi:10.1101/gr.176487.114 · Cited by 102
Association of histone modification with the development of schizophrenia
Chen, Y.-Z., Zhu, X.-M., Lv, P., Hou, X.-K., Pan, Y., Li, A., Du, Z., Xuan, J.-F., Guo, X., Xing, J.-X., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116747 · Cited by 18
Metadata
- Authors
- Wu, L., Zee, B. M., Wang, Y., Garcia, B. A., & Dou, Y.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 43
- Issue
- 1
- Pages
- 132-144
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1968085402
- Cited by
- 165
- References
- 1
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation. https://app.cochat.ai/papers/10.1016/j.molcel.2011.05.015
- The paper
- Wu, L., Zee, B. M., Wang, Y., Garcia, B. A., & Dou, Y. (2011). The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.05.015
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