The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation
Open accessAbstract
SUMMARY Angiogenin is a stress-activated ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or synthetic tiRNAs inhibits protein synthesis and triggers the phospho-eIF2α independent assembly of stress granules (SGs), essential components of the stress response program. We show that selected tiRNAs inhibit protein synthesis by displacing eIF4G/eIF4A from uncapped>capped RNAs. tiRNAs also displace eIF4F, but not eIF4E:4EBP1, from isolated m7G cap. We identify a terminal oligoguanine motif that is required to displace the eIF4F complex, inhibit translation, and induce SG assembly. We show that the tiRNA-associated translational silencer YB-1 contributes to angiogenin-, tiRNA-, and oxidative stress-induced translational repression. Our data reveal some of the mechanisms by which stress-induced tRNA cleavage inhibits protein synthesis and activates a cytoprotective stress response program.
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Cites
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
Lee, Y. S., Shibata, Y., Malhotra, A., & Dutta, A. (2009) · Genes & Development · doi:10.1101/gad.1837609 · Cited by 1,173
Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly
Emara, M. M., Ivanov, P., Hickman, T., Dawra, N., Tisdale, S., Kedersha, N., Hu, G.-F., & Anderson, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077560 · Cited by 500
Self-citation
Cited by
Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement
Goodarzi, H., Liu, X., Nguyen, H. C. B., Zhang, S., Fish, L., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.02.053 · Cited by 949
Stress granules and neurodegeneration
Wolozin, B., & Ivanov, P. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0222-5 · Cited by 810
Self-citationStress granules and cell signaling: more than just a passing phase?
Kedersha, N., Ivanov, P., & Anderson, P. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.07.004 · Cited by 631
Self-citationRNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
Tuorto, F., Liebers, R., Musch, T., Schaefer, M., Hofmann, S., Kellner, S., Frye, M., Helm, M., Stoecklin, G., & Lyko, F. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2357 · Cited by 631
Maute, R. L., Schneider, C., Sumazin, P., Holmes, A., Califano, A., Basso, K., & Dalla-Favera, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206761110 · Cited by 615
Metadata
- Authors
- Ivanov, P., Emara, M. M., Villen, J., Gygi, S. P., & Anderson, P.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 43
- Issue
- 4
- Pages
- 613-623
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2056831129
- Cited by
- 985
- References
- 2
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ivanov, P., Emara, M. M., Villen, J., Gygi, S. P., & Anderson, P. (2011). Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.06.022
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