Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis
Open accessAbstract
Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, both required for ribosome biogenesis. We report that transcription of the β-karyopherin genes importin 7 (IPO7) and exportin 1 (XPO1), and several additional nuclear import receptors, is regulated positively by c-Myc and negatively by p53. Partial IPO7 depletion triggers p53 activation and p53-dependent growth arrest. Activation of p53 by IPO7 knockdown has distinct features of ribosomal biogenesis stress, with increased binding of Mdm2 to ribosomal proteins L5 and L11 (RPL5 and RPL11). Furthermore, p53 activation is dependent on RPL5 and RPL11. Of note, IPO7 and XPO1 are frequently overexpressed in cancer. Altogether, we propose that c-Myc and p53 counter each other in the regulation of elements within the nuclear transport machinery, thereby exerting opposing effects on the rate of ribosome biogenesis. Perturbation of this balance may play a significant role in promoting cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Induction of p53 leads to downregulation of rRNA genes and of genes that are required for import and export of ribosomal proteins from the nucleus.
“Induction of p53 leads to downregulation of rRNA genes212, 213 and of genes that are required for import and export of ribosomal proteins from the nucleus.214”
From Census and evaluation of p53 target genes (2017) · cites this paper as [214]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 88 · Cited by 137
Research works printed but not linked: 2
- Frenkel-Morgenstern M Cohen AA Geva-Zatorsky N Eden E Prilusky J Issaeva I Sigal A Cohen-Saidon C Liron Y Cohen L 2010 Dynamic Proteomics: a database for dynamics and localizations of endogenous fluorescently-tagged proteins in living human cells Nucleic Acids Res 38 D508 512 19820112 PMC2808965
- van Riggelen J Yetil A Felsher DW 2010 MYC as a regulator of ribosome biogenesis and protein synthesis Nat Rev Cancer 10 301 309 20332779
- Authors
- Golomb, L., Bublik, D. R., Wilder, S., Nevo, R., Kiss, V., Grabusic, K., Volarevic, S., & Oren, M.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Oren, Moshe
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 45
- Issue
- 2
- Pages
- 222-232
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3270374
- OpenAlex
- W2072582894
- Cited by
- 137
- References
- 88
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 12 · 2020: 12 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 7
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-07-13)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Fondation pour la Recherche Médicale
- National Cancer Institute (R37 CA40099, R37CA040099)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- IMP-7, CRM1, ribosome biogenesis, c-Myc, p53, nuclear import, ribosomal proteins, MDM2, RPL5, ribosomal protein L11, cancer, transcriptional regulation
- MeSH terms
- Exportin 1 Protein, Humans, Ribosomal Proteins, Ribosomes, Stress, Physiological, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-myc, Receptors, Cytoplasmic and Nuclear, Active Transport, Cell Nucleus, Karyopherins, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
