Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

Soroka, Joanna, Wandinger, Sebastian K., Mäusbacher, Nina, Schreiber, Thiemo, Richter, Klaus, Daub, Henrik, Buchner, Johannes·2012·Molecular Cell
DOI 10.1016/j.molcel.2011.12.031

Cited by (139)

Items 101–139 of 139

  1. Allosteric Activation of Protein Phosphatase 5 with Small Molecules
    Qiuyue Zhang, Ling Yan, Lixiao Zhang, Jia Yu, Zeyu han, Hua Liu, Jinying Gu, Keran Wang, Jiayi Wang, Fangsu Chen et al. · 2024 · Journal of Medicinal Chemistry
  2. Identification of a chaperone-code responsible for Rad51-mediated genome repair
    Khushboo Rani, Akanksha Gotmare, Andreas Maier, Ruchira Menghal, Nashat Akhtar, Nupur Fangaria, Johannes Büchner, Sunanda Bhattacharyya · 2024 · Journal of Biological Chemistry
  3. SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress
    Ana C. Liberman, Maia Ludmila Budziñski, Clara Sokn, Romina P. Gobbini, Maria Belén Ugo, EDUARDO S. ARZT · 2019 · Steroids
  4. Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes
    Rahul S. Samant, Sílvia Batista, Mark Larance, Buğra Özer, Christopher I. Milton, Isabell Bludau, Estelle Wu, Laura Biggins, Simon Andrews, Alexia Hervieu et al. · 2022 · Molecular & Cellular Proteomics
  5. Mechanistic aspects of the Hsp90 phosphoregulation
    Joanna Soroka, Johannes Büchner · 2012 · Cell Cycle
  6. Ordered ATP hydrolysis in the Hsp90 chaperone is regulated by Aha1 and a conserved post‐translational modification
    Desmond Prah Amoah, Solomon K. Hussein, Jill L. Johnson, Paul LaPointe · 2024 · Protein Science
  7. Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function
    Sarah J. Backe, Mehdi Mollapour, Mark R. Woodford · 2023 · Essays in Biochemistry
  8. Modification of Regulatory Tyrosine Residues Biases Human Hsp90α in its Interactions with Cochaperones and Clients
    Yuantao Huo, Rishabh Karnawat, Lixia Liu, Robert A. Knieß, Maike Groß, Xuemei Chen, Matthias P. Mayer · 2024 · Journal of Molecular Biology
  9. Surviving the Storm: How Candida Species Master Adaptation for Pathogenesis
    Aishwarya Rana, Nidhi Gupta, Shumaiza Asif, Anil Thakur · 2024 · Springer eBooks
  10. Computational Studies of Allosteric Regulation in the Hsp90 Molecular Chaperone: From Functional Dynamics and Protein Structure Networks to Allosteric Communications and Targeted Anti‐Cancer Modulators
    Gennady M. Verkhivker · 2014 · Israel Journal of Chemistry
  11. Dissecting Molecular Principles of the Hsp90 Chaperone Regulation by Allosteric Modulators Using a Hierarchical Simulation Approach and Network Modeling of Allosteric Interactions: Conformational Selection Dictates the Diversity of Protein Responses and Ligand-Specific Functional Mechanisms
    Lindy Astl, Gabrielle Stetz, Gennady M. Verkhivker · 2020 · Journal of Chemical Theory and Computation
  12. Progress in Molecular Chaperone Regulation of Heat Shock Protein 90 and Cancer
    ZHAI Rui, Gong Xiao-Yun, XIONG Xing-Chuang, You Jiang, Zejian Huang, Fang Xiang · 2018 · Chinese Journal of Analytical Chemistry
  13. Investigation of the Hsp90 C-terminal Binding Site, Novel Inhibitors and Isoform-Dependent Client Proteins
    Laura B. Peterson · 2012 · KU ScholarWorks (The University of Kansas)
  14. Second international symposium on the chaperone code, 2023
    Johannes Büchner, Milad J. Alasady, Sarah J. Backe, Brian S. J. Blagg, Richard L. Carpenter, Giorgio Colombo, Ioannis Gelis, Daniel T. Gewirth, Lila M. Gierasch, Walid A. Houry et al. · 2024 · Cell Stress and Chaperones
  15. The Chaperone Networks: A Heat Shock Protein (Hsp)70 Perspective
    Verónica Marlene González García, Kevin A. Morano · 2014 · Springer eBooks
  16. Exploring Small Heat Shock Proteins (sHSPs) for Targeting Drug Resistance in Candida albicans and other Pathogenic Fungi
    Rahul Dev · 2021 · Journal of Pure and Applied Microbiology
  17. Detecting Posttranslational Modifications of Hsp90 Isoforms
    Rebecca Sager, Sarah J. Backe, Len Neckers, Mark R. Woodford, Mehdi Mollapour · 2023 · Methods in molecular biology
  18. The Pivotal Role of CK2 in the Kinome‐Targeting Hsp90 Chaperone Machinery
    Yoshihiko Miyata · 2013
  19. Patient preference study of two potassium chloride supplements: Slow-K and Micro-K 10 Extencaps.
    MARTIN ZUKOF · 1991 · PubMed
  20. A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogen Candida albicans
    Leenah Alaalm, Julia L. Crunden, Mark C. Butcher, Ulrike Obst, Ryann N. Whealy, Carolyn E. Williamson, Heath O’Brien, Christiane Schaffitzel, Gordon Ramage, Stephanie Diezmann · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  21. An isotype-specific phosphorylation of Hsp90 rewires co-chaperone regulations
    Tisya Banerjee, Elisabetta Moroni, Maximilian Riedl, Giorgio Colombo, Johannes Büchner · 2026 · Journal of Biological Chemistry
  22. A Novel Hypoxic-Angiogenesis-Immune-Related Gene Model for Prognostic and Therapeutic Effect Prediction in Hepatocellular Carcinoma Patients
    Wen Lv, Qi Yao · 2022 · Disease Markers
  23. Essential anticandidal targets
    Awanish Kumar, Anubhuti Jha · 2023 · Elsevier eBooks
  24. Distinct phosphorylation mechanisms as dynamic switches for Hsp90 regulation
    Chanjuan Wan, Lei Zhu, Simin Wang, Xueqing Zhang, Jun Zhao, Xiaozhan Qu, Chengdong Huang · 2026 · Nature Communications
  25. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products
    Yue Hu, Xiao J. Zhang, Xiao T. Yang, Ying Ying Tang, Lin Yu Hu, Dong Zhu · 2019 · Heat shock proteins
  26. Hsp90 as a Member of Dicarboxylate Clamp TPR Protein Interaction Network: Implication in Human Diseases and Prospect as a Drug Target
    Rajnish Kumar, Bengt G. Winblad, Pavel F. Pavlov · 2019 · Heat shock proteins
  27. An Enhanced Repository of Protein Structure Pairs before and after Binding
    Tien-Hao Chang, Wen-Hao Chiang, Hao Wang · 2013 · Seitai ikougaku/Seitai ikogaku
  28. Composition, regulation, and function of protein serine/threonine phosphatase.kinase signaling modules
    Matthew D. Mazalouskas · 2014
  29. Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors
    Lu Lin · 2013
  30. Conformational Fluctuations of Biomolecules Studied Using Molecular Dynamics and Enhanced Sampling
    Geoffrey Gray · 2018 · Digital Commons - University of South Florida (University of South Florida)
  31. Способность цитофлавина влиять на антиоксидантную систему защиты организма
    Olga A. Goroshko, О. А. Чеча, Е. Ю. Демченкова · 2011 · Биомедицина
  32. Hsp90 Chaperones
    Bettina K. Zierer, Johannes Büchner · 2012 · Wiley eBooks
  33. Faculty Opinions recommendation of A methylated lysine is a switch point for conformational communication in the chaperone Hsp90.
    Mehdi Mollapour · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  34. Modification of regulatory tyrosines biases human Hsp90α for interaction with cochaperones and clients
    Yuantao Huo, Rishabh Karnawat, Lixia Liu, Robert A. Knieß, Maike Gross, Xuemei Chen, Matthias P. Mayer · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Etude structurale et fonctionnelle de la phosphatase humaine PTPN4
    Pierre Maisonneuve · 2014 · theses.fr (ABES)
  36. Etude des principes d’assemblage et de maturation des kinases de la famille des PIKKs chez Schizosaccharomyces pombe
    Damien Toullec · 2020 · theses.fr (ABES)
  37. Nucleotide-dependent domain interactions of Aha1-type co-chaperones with Hsp90 reveal evolutionarily conserved binding determinants
    Desmond Prah Amoah, Rakesh Kumar Bhat, Malak Trad, Solomon K. Hussein, Michael Overduin, Paul LaPointe · 2026 · Cell Stress and Chaperones
  38. BindingDB Entry 50019349: Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery.
    BindingDB · 2024 · UC San Diego
  39. BindingDB Entry 50021991: Allosteric Activation of Protein Phosphatase 5 with Small Molecules.
    BindingDB · 2025 · UC San Diego