Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Brouwer, Jason M., Westphal, Dana, Dewson, Grant, Robin, Adeline Y., Uren, Rachel T., Bartolo, Ray, Thompson, Geoff V., Colman, Peter M. +2 more·2014·Molecular Cell

Cited by (162)

Items 101–162 of 162

  1. Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
    Allan Shuai Huang, Hui San Chin, Boris Reljić, Tirta Mario Djajawi, Iris K. L. Tan, Jianan Gong, David A. Stroud, David C.S. Huang, Mark F. van Delft, Grant Dewson · 2022 · Cell Death and Differentiation
  2. Structural insight into tanapoxvirus‐mediated inhibition of apoptosis
    Chathura D. Suraweera, Mohd Ishtiaq Anasir, Srishti Chugh, Airah Javorsky, Rachael E. Impey, Mohammad Hasan Zadeh, Tatiana P. Soares da Costa, Mark G. Hinds, Marc Kvansakul · 2020 · FEBS Journal
  3. Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5
    Sebastian Rühl, Zhenrui Li, Shagun Srivastava, Luigi Mari, Clifford S. Guy, Mao Yang, Tudor Moldoveanu, Douglas R. Green · 2024 · Cell Death and Differentiation
  4. BAX mitochondrial integration is regulated allosterically by its α1−α2 loop
    Michael A. Dengler, Leonie Gibson, Jerry M. Adams · 2021 · Cell Death and Differentiation
  5. At the Crossroads of Life and Death: The Proteins That Influence Cell Fate Decisions
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  6. Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization
    Fiona Aguilar, Stacey J. Yu, Robert A. Grant, Sebastian Swanson, Dia A. Ghose, Bonnie G. Su, Kristopher A. Sarosiek, Amy E. Keating · 2023 · Structure
  7. Molecular Determinants for the Activation/Inhibition of Bak Protein by BH3 Peptides
    Guillem Vila-Julià, José M. Granadino‐Roldán, Juan Jesús Pérez, J. Rubio · 2020 · Journal of Chemical Information and Modeling
  8. Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK
    Olatz Landeta, Ane Landajuela, Ana J. García‐Sáez, Gorka Basáñez · 2015 · Journal of Biological Chemistry
  9. Eltrombopag directly activates BAK and induces apoptosis
    Meng Chen, Lei Hu, Xuyuan Bao, Kaiqin Ye, Yunjian Li, Zhiyong Zhang, Scott H. Kaufmann, Jun Xiao, Haiming Dai · 2023 · Cell Death and Disease
  10. X-ray crystallography shines a light on pore-forming toxins
    Bronte A. Johnstone, Michelle P. Christie, Craig J. Morton, Michael W. Parker · 2021 · Methods in enzymology on CD-ROM/Methods in enzymology
  11. The Tail-End Is Only the Beginning: NMR Study Reveals a Membrane-Bound State of BCL-XL
    R. Blake Hill, Kevin R. MacKenzie, Megan Cleland Harwig · 2015 · Journal of Molecular Biology
  12. Lipid-Dependent Bimodal MCL1 Membrane Activity
    Olatz Landeta, Juan García Valero, Hector Flores‐Romero, Itsasne Bustillo Zabalbeitia, Ane Landajuela, Miguel García‐Porras, Oihana Terrones, Gorka Basáñez · 2014 · ACS Chemical Biology
  13. Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice
    Natasha S. Anstee, Cassandra J. Vandenberg, Kirsteen J. Campbell, Peter Hughes, Lorraine Ann O’Reilly, Suzanne Cory · 2016 · Cell Death and Differentiation
  14. Preferred inhibition of pro-apoptotic Bak by BclxL via a two-step mechanism
    Kira D. Leitl, Laura E. Sperl, Franz Hagn · 2024 · Cell Reports
  15. Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove
    Peng Cheng, Yuzhu Hou, Mingxing Bian, Xueru Fang, Yan Liu, Yuanfang Rao, Shuo Cao, Yanjun Liu, Shuai Zhang, Yanke Chen et al. · 2023 · Communications Biology
  16. Study of the Bcl-2 Interactome by BiFC Reveals Differences in the Activation Mechanism of Bax and Bak
    Óscar Gonzalo, Andrea Benedi, Laura Vela, Alberto Anel, Javier Naval, Isabel Marzo · 2023 · Cells
  17. Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation
    Adeline Y. Robin, Michelle S. Miller, Sweta Iyer, Melissa X. Shi, Ahmad Z. Wardak, Daisy Sio Seng Lio, Nicholas A. Smith, Brian James Smith, Richard W. Birkinshaw, Peter E. Czabotar et al. · 2022 · Cell Death and Differentiation
  18. Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice
    Rebecca A. Bilardi, Natasha S. Anstee, Stefan P. Glaser, Mikara Robati, Cassandra J. Vandenberg, Suzanne Cory · 2016 · Cell Death and Disease
  19. Diversity in the intrinsic apoptosis pathway of nematodes
    Neil David Young, Tiffany J. Harris, Marco Evangelista, Sharon H. Tran, Merridee A. Wouters, Tatiana P. Soares da Costa, Nadia J. Kershaw, Robin B. Gasser, Brian James Smith, Erinna F. Lee et al. · 2020 · Communications Biology
  20. Methods to Probe Conformational Activation and Mitochondrial Activity of Proapoptotic BAK
    Geetika Singh, Tudor Moldoveanu · 2018 · Methods in molecular biology
  21. Disordered clusters of Bak dimers rupture mitochondria during apoptosis
    Rachel T. Uren, Martin O’Hely, Sweta Iyer, Ray C. Bartolo, Jason M. Brouwer, Amber E. Alsop, Grant Dewson, Ruth M. Kluck · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Function, mechanism of action, metabolism, and commercial application of Lonicera japonica: a review
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  23. A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells
    Hema Preethi Subas Satish, Sweta Iyer, Melissa X. Shi, Agnes W. Wong, Karla C. Fischer, Ahmad Z. Wardak, Daisy Sio Seng Lio, Jason M. Brouwer, Rachel T. Uren, Peter E. Czabotar et al. · 2024 · Cell Death and Differentiation
  24. Linker Histone H1.2 Directly Activates BAK through the K/RVVKP Motif on the C-Terminal Domain
    R. Schnetler, Sylvia Fanucchi, Tudor Moldoveanu, Gerrit Koorsen · 2020 · Biochemistry
  25. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc
    Erik Ingmar Hallin, Sigurbjörn Markússon, Lev Böttger, Andrew E. Torda, Clive R. Bramham, Petri Kursula · 2021 · PLoS ONE
  26. BAK and BAX: Therapeutic Targets for Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury
    Zejun Xu, Fei Meng, Hongjun Yang, Ying Liu, Kaiqin Ye, Fei Qin, Dongyan Liu, Haiming Dai · 2025 · Biology
  27. Characterizing Bcl-2 Family Protein Conformation and Oligomerization Using Cross-Linking and Antibody Gel-Shift in Conjunction with Native PAGE
    Grant Dewson · 2016 · Methods in molecular biology
  28. Computational design of potent and selective binders of BAK and BAX
    Stephanie Berger, Erinna F. Lee, Tiffany J. Harris, Sharon H. Tran, Asim K. Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S. Miller et al. · 2025 · Science Advances
  29. Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies
    Konstantina Athanasopoulou, Panagiotis G. Adamopoulos, Glykeria N. Daneva, Andreas Scorilas · 2022 · APOPTOSIS
  30. A Joint Odyssey into Cancer Genetics
    Suzanne Cory, Jerry M. Adams · 2018 · Annual Review of Cancer Biology
  31. CW EPR and DEER Methods to Determine BCL-2 Family Protein Structure and Interactions: Application of Site-Directed Spin Labeling to BAK Apoptotic Pores
    Tirtha Mandal, Eric J. Hustedt, Likai Song, Kyoung Joon Oh · 2018 · Methods in molecular biology
  32. Anti-apoptotic BH3-only proteins inhibit Bak-dependent apoptosis
    Sebastian Rühl, Clifford S. Guy, Zhenrui Li, Mao Yang, Tudor Moldoveanu, Douglas R. Green · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis
    Tomomi Kuwana · 2016 · Nanotechnology Reviews
  34. Lipids glue BAK dimers together
    Hector Flores‐Romero, Ana J. García‐Sáez · 2020 · Nature Structural & Molecular Biology
  35. The Bak core dimer focuses triacylglycerides in the membrane
    Nicholas A. Smith, Ahmad Z. Wardak, Angus D. Cowan, Peter M. Colman, Peter E. Czabotar, Brian James Smith · 2021 · Biophysical Journal
  36. Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1
    Dahwan Lim, So-Hui Choe, Sein Jin, Seulgi Lee, Younjin Kim, Ho‐Chul Shin, Joon Sig Choi, Doo‐Byoung Oh, Seung Jun Kim, Jin‐Ho Seo et al. · 2023 · PLoS Biology
  37. Therapeutics targeting BCL2 family proteins
    Haiming Dai, X. Wei Meng, Kaiqin Ye, Jia Jia, Scott H. Kaufmann · 2021 · Elsevier eBooks
  38. The roles of ubiquitination‐mediated intrinsic apoptotic signalling in cancer therapy
    Tiantian Che, Zhenghong Lin · 2022 · Clinical and Translational Discovery
  39. Spontaneous oligomerization of BAK/BAX is suppressed by hetero-dimerization with MCL-1
    Basile I. M. Wicky, Kallol Gupta, Tristan O. C. Kwan, Carol V. Robinson, Jane Clarke · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  40. The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential
    Mark F. van Delft, Grant Dewson · 2022 · Elsevier eBooks
  41. Design, Synthesis, and Evaluation of Phenylpyrrole Derivatives as Small-Molecule Activators of BAX
    Wei Cai, Zuo Li, Meiling Zhao, Yiwen Gu, Chenyang Qiu, Mi Zhou, Wei Deng, Lu Zhou, Yan Li, Renxiao Wang · 2026 · Journal of Medicinal Chemistry
  42. Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain‐containing protein
    Dahwan Lim, Da Eun Jeong, Ho‐Chul Shin, Joon Sig Choi, Jinho Seo, Seung Jun Kim, Bonsu Ku · 2023 · Proteins Structure Function and Bioinformatics
  43. Nesprin-2 contains BH3-like motifs that can promote cell death
    Hila Zohar, Amit Kessel, Liora Lindenboim, Dang Quan Nguyen, Nir Ben‐Tal, Gregg G. Gundersen, Howard J. Worman, David William Andrews, Reuven Stein · 2025 · Cell Death Discovery
  44. Structural insight into tanapoxvirus mediated inhibition of apoptosis
    Chathura D. Suraweera, Mohd Ishtiaq Anasir, Srishti Chugh, Airah Javorsky, Rachael E. Impey, Mohammad Hasan Zadeh, Tatiana P. Soares da Costa, Mark G. Hinds, Marc Kvansakul · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc
    Erik Ingmar Hallin, Sigurbjörn Markússon, Lev Böttger, Andrew E. Torda, Clive R. Bramham, Petri Kursula · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  46. The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential
    David William Andrews, Hetal Brahmbhatt, Brian F. Leber · 2015 · Elsevier eBooks
  47. E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
    Allan Shuai Huang, Hui San Chin, Boris Reljić, Tirta Mario Djajawi, Iris K. L. Tan, David A. Stroud, David C.S. Huang, Mark F. van Delft, Grant Dewson · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Discovery of diverse human BH3-only and non-native peptide binders of pro-apoptotic BAK indicate that activators and inhibitors use a similar binding mode and are not distinguished by binding affinity or kinetics
    Fiona Aguilar, Stacey J. Yu, Robert A. Grant, Sebastian Swanson, Dia A. Ghose, Bonnie G. Su, Kristopher A. Sarosiek, Amy E. Keating · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Control of Cell Survival and Apoptosis
    Daniel H.D. Gray, Andreas Strasser · 2016 · Elsevier eBooks
  50. Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
    Geetika Singh · 2020
  51. Faculty Opinions recommendation of Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.
    Anne Kathrin Voss · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  52. Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis
    Zhengwei Yuan, Mark F. van Delft, Xiang Li, Fransisca Sumardy, Brian James Smith, David C.S. Huang, Guillaume Lessène, Yelena Khakam, Ruitao Jin, Sitong He et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  53. An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death
    Elena Terraza-Silvestre, Raquel Villamuera, Julia Bandera-Linero, Michal Letek, Cristina Ramón-Barros, Clara Moyano-Jimeno, Daniel Oña-Sánchez, Felipe X. Pimentel‐Muiños · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Crystallization and preliminary diffraction analysis of Bak incubated with eltrombopag
    Dahwan Lim, So Hyeon Park, Ho‐Chul Shin, Seung Jun Kim, Bonsu Ku · 2024 · Korean Society for Structural Biology
  55. A lipid signature of BAK-driven apoptotic pore formation
    Rachel T. Uren, Matthew E. Ritchie, Agnes W. Wong, Justin P. Ludeman, Etsuko Uno, Vinod K. Narayana, David Peter De Souza, Dmitri Sviridov, Ruth M. Kluck · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Control of Cell Survival and Apoptosis
    Daniel H.D. Gray, Andreas Strasser · 2016 · Elsevier eBooks
  57. Decoding the Heterodimer Stability of Pro-Apoptotic Effectors via Multiscale Simulations: Mutational Insights Into Mitochondrial Signaling.
    Pratyush Pani, A. Shree, M. K. Rana · 2026 · ChemPhysChem
  58. Drugging the proteome via large-scale chemoproteomics.
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    Chunye Long, Haitao Zhang, Yiyan Yao, Tang Liu, Hongling Peng, Yue Sheng · 2026 · Heliyon
  60. Direct binding of the C-terminal sequences of Bim and Bak contributes to efficient Bak activation
    Dang Nguyen, Sabina Trebinjac, Tobias B. Beigl, Frank Eßmann, Kathryn M. Murphy, David William Andrews · 2026 · Cell Death and Differentiation
  61. The Executioners of Mitochondrial Apoptosis: Structures, Mechanisms, and Therapeutic Advances of BAX, BAK, and BOK
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  62. BindingDB Entry 50018637: Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.
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