Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers
Brouwer, Jason M., Westphal, Dana, Dewson, Grant, Robin, Adeline Y., Uren, Rachel T., Bartolo, Ray, Thompson, Geoff V., Colman, Peter M. +2 more·2014·Molecular Cell
Cited by (162)
Items 101–162 of 162
- Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteinsAllan Shuai Huang, Hui San Chin, Boris Reljić, Tirta Mario Djajawi, Iris K. L. Tan, Jianan Gong, David A. Stroud, David C.S. Huang, Mark F. van Delft, Grant Dewson · 2022 · Cell Death and Differentiation
- Structural insight into tanapoxvirus‐mediated inhibition of apoptosisChathura D. Suraweera, Mohd Ishtiaq Anasir, Srishti Chugh, Airah Javorsky, Rachael E. Impey, Mohammad Hasan Zadeh, Tatiana P. Soares da Costa, Mark G. Hinds, Marc Kvansakul · 2020 · FEBS Journal
- Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5Sebastian Rühl, Zhenrui Li, Shagun Srivastava, Luigi Mari, Clifford S. Guy, Mao Yang, Tudor Moldoveanu, Douglas R. Green · 2024 · Cell Death and Differentiation
- BAX mitochondrial integration is regulated allosterically by its α1−α2 loopMichael A. Dengler, Leonie Gibson, Jerry M. Adams · 2021 · Cell Death and Differentiation
- At the Crossroads of Life and Death: The Proteins That Influence Cell Fate DecisionsVinesh Dhokia, John A. Y. Moss, Salvador Macip, Joanna L. Fox · 2022 · Cancers
- Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilizationFiona Aguilar, Stacey J. Yu, Robert A. Grant, Sebastian Swanson, Dia A. Ghose, Bonnie G. Su, Kristopher A. Sarosiek, Amy E. Keating · 2023 · Structure
- Molecular Determinants for the Activation/Inhibition of Bak Protein by BH3 PeptidesGuillem Vila-Julià, José M. Granadino‐Roldán, Juan Jesús Pérez, J. Rubio · 2020 · Journal of Chemical Information and Modeling
- Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAKOlatz Landeta, Ane Landajuela, Ana J. García‐Sáez, Gorka Basáñez · 2015 · Journal of Biological Chemistry
- Eltrombopag directly activates BAK and induces apoptosisMeng Chen, Lei Hu, Xuyuan Bao, Kaiqin Ye, Yunjian Li, Zhiyong Zhang, Scott H. Kaufmann, Jun Xiao, Haiming Dai · 2023 · Cell Death and Disease
- X-ray crystallography shines a light on pore-forming toxinsBronte A. Johnstone, Michelle P. Christie, Craig J. Morton, Michael W. Parker · 2021 · Methods in enzymology on CD-ROM/Methods in enzymology
- The Tail-End Is Only the Beginning: NMR Study Reveals a Membrane-Bound State of BCL-XLR. Blake Hill, Kevin R. MacKenzie, Megan Cleland Harwig · 2015 · Journal of Molecular Biology
- Lipid-Dependent Bimodal MCL1 Membrane ActivityOlatz Landeta, Juan García Valero, Hector Flores‐Romero, Itsasne Bustillo Zabalbeitia, Ane Landajuela, Miguel García‐Porras, Oihana Terrones, Gorka Basáñez · 2014 · ACS Chemical Biology
- Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr miceNatasha S. Anstee, Cassandra J. Vandenberg, Kirsteen J. Campbell, Peter Hughes, Lorraine Ann O’Reilly, Suzanne Cory · 2016 · Cell Death and Differentiation
- Preferred inhibition of pro-apoptotic Bak by BclxL via a two-step mechanismKira D. Leitl, Laura E. Sperl, Franz Hagn · 2024 · Cell Reports
- Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groovePeng Cheng, Yuzhu Hou, Mingxing Bian, Xueru Fang, Yan Liu, Yuanfang Rao, Shuo Cao, Yanjun Liu, Shuai Zhang, Yanke Chen et al. · 2023 · Communications Biology
- Study of the Bcl-2 Interactome by BiFC Reveals Differences in the Activation Mechanism of Bax and BakÓscar Gonzalo, Andrea Benedi, Laura Vela, Alberto Anel, Javier Naval, Isabel Marzo · 2023 · Cells
- Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activationAdeline Y. Robin, Michelle S. Miller, Sweta Iyer, Melissa X. Shi, Ahmad Z. Wardak, Daisy Sio Seng Lio, Nicholas A. Smith, Brian James Smith, Richard W. Birkinshaw, Peter E. Czabotar et al. · 2022 · Cell Death and Differentiation
- Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in miceRebecca A. Bilardi, Natasha S. Anstee, Stefan P. Glaser, Mikara Robati, Cassandra J. Vandenberg, Suzanne Cory · 2016 · Cell Death and Disease
- Diversity in the intrinsic apoptosis pathway of nematodesNeil David Young, Tiffany J. Harris, Marco Evangelista, Sharon H. Tran, Merridee A. Wouters, Tatiana P. Soares da Costa, Nadia J. Kershaw, Robin B. Gasser, Brian James Smith, Erinna F. Lee et al. · 2020 · Communications Biology
- Methods to Probe Conformational Activation and Mitochondrial Activity of Proapoptotic BAKGeetika Singh, Tudor Moldoveanu · 2018 · Methods in molecular biology
- Disordered clusters of Bak dimers rupture mitochondria during apoptosisRachel T. Uren, Martin O’Hely, Sweta Iyer, Ray C. Bartolo, Jason M. Brouwer, Amber E. Alsop, Grant Dewson, Ruth M. Kluck · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
- Function, mechanism of action, metabolism, and commercial application of Lonicera japonica: a reviewXinli Yang, Dan Yan · 2024 · Food Science and Human Wellness
- A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cellsHema Preethi Subas Satish, Sweta Iyer, Melissa X. Shi, Agnes W. Wong, Karla C. Fischer, Ahmad Z. Wardak, Daisy Sio Seng Lio, Jason M. Brouwer, Rachel T. Uren, Peter E. Czabotar et al. · 2024 · Cell Death and Differentiation
- Linker Histone H1.2 Directly Activates BAK through the K/RVVKP Motif on the C-Terminal DomainR. Schnetler, Sylvia Fanucchi, Tudor Moldoveanu, Gerrit Koorsen · 2020 · Biochemistry
- Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila ArcErik Ingmar Hallin, Sigurbjörn Markússon, Lev Böttger, Andrew E. Torda, Clive R. Bramham, Petri Kursula · 2021 · PLoS ONE
- BAK and BAX: Therapeutic Targets for Acute Myocardial Infarction and Myocardial Ischemia-Reperfusion InjuryZejun Xu, Fei Meng, Hongjun Yang, Ying Liu, Kaiqin Ye, Fei Qin, Dongyan Liu, Haiming Dai · 2025 · Biology
- Characterizing Bcl-2 Family Protein Conformation and Oligomerization Using Cross-Linking and Antibody Gel-Shift in Conjunction with Native PAGEGrant Dewson · 2016 · Methods in molecular biology
- Computational design of potent and selective binders of BAK and BAXStephanie Berger, Erinna F. Lee, Tiffany J. Harris, Sharon H. Tran, Asim K. Bera, Lauren Arguinchona, Alex Kang, Banumathi Sankaran, Sila Kasapgil, Michelle S. Miller et al. · 2025 · Science Advances
- Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignanciesKonstantina Athanasopoulou, Panagiotis G. Adamopoulos, Glykeria N. Daneva, Andreas Scorilas · 2022 · APOPTOSIS
- A Joint Odyssey into Cancer GeneticsSuzanne Cory, Jerry M. Adams · 2018 · Annual Review of Cancer Biology
- CW EPR and DEER Methods to Determine BCL-2 Family Protein Structure and Interactions: Application of Site-Directed Spin Labeling to BAK Apoptotic PoresTirtha Mandal, Eric J. Hustedt, Likai Song, Kyoung Joon Oh · 2018 · Methods in molecular biology
- Anti-apoptotic BH3-only proteins inhibit Bak-dependent apoptosisSebastian Rühl, Clifford S. Guy, Zhenrui Li, Mao Yang, Tudor Moldoveanu, Douglas R. Green · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosisTomomi Kuwana · 2016 · Nanotechnology Reviews
- Lipids glue BAK dimers togetherHector Flores‐Romero, Ana J. García‐Sáez · 2020 · Nature Structural & Molecular Biology
- The Bak core dimer focuses triacylglycerides in the membraneNicholas A. Smith, Ahmad Z. Wardak, Angus D. Cowan, Peter M. Colman, Peter E. Czabotar, Brian James Smith · 2021 · Biophysical Journal
- Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1Dahwan Lim, So-Hui Choe, Sein Jin, Seulgi Lee, Younjin Kim, Ho‐Chul Shin, Joon Sig Choi, Doo‐Byoung Oh, Seung Jun Kim, Jin‐Ho Seo et al. · 2023 · PLoS Biology
- Therapeutics targeting BCL2 family proteinsHaiming Dai, X. Wei Meng, Kaiqin Ye, Jia Jia, Scott H. Kaufmann · 2021 · Elsevier eBooks
- The roles of ubiquitination‐mediated intrinsic apoptotic signalling in cancer therapyTiantian Che, Zhenghong Lin · 2022 · Clinical and Translational Discovery
- Spontaneous oligomerization of BAK/BAX is suppressed by hetero-dimerization with MCL-1Basile I. M. Wicky, Kallol Gupta, Tristan O. C. Kwan, Carol V. Robinson, Jane Clarke · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic PotentialMark F. van Delft, Grant Dewson · 2022 · Elsevier eBooks
- Design, Synthesis, and Evaluation of Phenylpyrrole Derivatives as Small-Molecule Activators of BAXWei Cai, Zuo Li, Meiling Zhao, Yiwen Gu, Chenyang Qiu, Mi Zhou, Wei Deng, Lu Zhou, Yan Li, Renxiao Wang · 2026 · Journal of Medicinal Chemistry
- Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain‐containing proteinDahwan Lim, Da Eun Jeong, Ho‐Chul Shin, Joon Sig Choi, Jinho Seo, Seung Jun Kim, Bonsu Ku · 2023 · Proteins Structure Function and Bioinformatics
- Nesprin-2 contains BH3-like motifs that can promote cell deathHila Zohar, Amit Kessel, Liora Lindenboim, Dang Quan Nguyen, Nir Ben‐Tal, Gregg G. Gundersen, Howard J. Worman, David William Andrews, Reuven Stein · 2025 · Cell Death Discovery
- Structural insight into tanapoxvirus mediated inhibition of apoptosisChathura D. Suraweera, Mohd Ishtiaq Anasir, Srishti Chugh, Airah Javorsky, Rachael E. Impey, Mohammad Hasan Zadeh, Tatiana P. Soares da Costa, Mark G. Hinds, Marc Kvansakul · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila ArcErik Ingmar Hallin, Sigurbjörn Markússon, Lev Böttger, Andrew E. Torda, Clive R. Bramham, Petri Kursula · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic PotentialDavid William Andrews, Hetal Brahmbhatt, Brian F. Leber · 2015 · Elsevier eBooks
- E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteinsAllan Shuai Huang, Hui San Chin, Boris Reljić, Tirta Mario Djajawi, Iris K. L. Tan, David A. Stroud, David C.S. Huang, Mark F. van Delft, Grant Dewson · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Discovery of diverse human BH3-only and non-native peptide binders of pro-apoptotic BAK indicate that activators and inhibitors use a similar binding mode and are not distinguished by binding affinity or kineticsFiona Aguilar, Stacey J. Yu, Robert A. Grant, Sebastian Swanson, Dia A. Ghose, Bonnie G. Su, Kristopher A. Sarosiek, Amy E. Keating · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Control of Cell Survival and ApoptosisDaniel H.D. Gray, Andreas Strasser · 2016 · Elsevier eBooks
- Mechanisms of BAK Activation in the Initiation of Mitochondrial ApoptosisGeetika Singh · 2020
- Faculty Opinions recommendation of Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.Anne Kathrin Voss · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosisZhengwei Yuan, Mark F. van Delft, Xiang Li, Fransisca Sumardy, Brian James Smith, David C.S. Huang, Guillaume Lessène, Yelena Khakam, Ruitao Jin, Sitong He et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell deathElena Terraza-Silvestre, Raquel Villamuera, Julia Bandera-Linero, Michal Letek, Cristina Ramón-Barros, Clara Moyano-Jimeno, Daniel Oña-Sánchez, Felipe X. Pimentel‐Muiños · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Crystallization and preliminary diffraction analysis of Bak incubated with eltrombopagDahwan Lim, So Hyeon Park, Ho‐Chul Shin, Seung Jun Kim, Bonsu Ku · 2024 · Korean Society for Structural Biology
- A lipid signature of BAK-driven apoptotic pore formationRachel T. Uren, Matthew E. Ritchie, Agnes W. Wong, Justin P. Ludeman, Etsuko Uno, Vinod K. Narayana, David Peter De Souza, Dmitri Sviridov, Ruth M. Kluck · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Control of Cell Survival and ApoptosisDaniel H.D. Gray, Andreas Strasser · 2016 · Elsevier eBooks
- Decoding the Heterodimer Stability of Pro-Apoptotic Effectors via Multiscale Simulations: Mutational Insights Into Mitochondrial Signaling.Pratyush Pani, A. Shree, M. K. Rana · 2026 · ChemPhysChem
- Drugging the proteome via large-scale chemoproteomics.Yushu Li, Jiaqi Wang, Tiantian Wang, Xisong Ke, Yi Qu · 2026 · TIBS -Trends in Biochemical Sciences. Regular ed
- The advancement of Venetoclax in hematological malignancies and solid tumorsChunye Long, Haitao Zhang, Yiyan Yao, Tang Liu, Hongling Peng, Yue Sheng · 2026 · Heliyon
- Direct binding of the C-terminal sequences of Bim and Bak contributes to efficient Bak activationDang Nguyen, Sabina Trebinjac, Tobias B. Beigl, Frank Eßmann, Kathryn M. Murphy, David William Andrews · 2026 · Cell Death and Differentiation
- The Executioners of Mitochondrial Apoptosis: Structures, Mechanisms, and Therapeutic Advances of BAX, BAK, and BOKHudie Wei, Jiaqi Wang, Jiayan Jiang, Shuyan Dai · 2026 · Medicinal Research Reviews
- BindingDB Entry 50018637: Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.BindingDB · 2024 · UC San Diego