Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon

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7. Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase
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8. Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy
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15. Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth
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16. Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4CRBN Protein Degradation Axis
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17. Thalidomide-induced limb malformations: an update and reevaluation
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18. Recent Advancements in the Discovery of Cereblon-Based Protease-Targeted Chimeras With Potential for Therapeutic Intervention
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19. The CRL3 gigaxonin ubiquitin ligase–USP15 pathway governs the destruction of neurofilament proteins
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20. Cereblon-mediated degradation of the amyloid precursor protein via the ubiquitin-proteasome pathway
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22. Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
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24. Macrophage Stimulated by Low Ambient Temperature Hasten Tumor Growth via Glutamine Production
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26. SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL
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27. A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
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28. Emerging roles and regulatory mechanisms involved in glutamine metabolism
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29. Differential Analysis of Cereblon Neosubstrates in Rabbit Embryos Using Targeted Proteomics
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30. Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment
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31. Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival
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33. HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
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34. Lysine‐372‐dependent SUMOylation inhibits the enzymatic activity of glutamine synthases
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35. Enhanced homeostatic sleep response and decreased neurodegenerative proteins in cereblon knock-out mice
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36. Discovery of New Immunomodulatory Anticancer Thalidomide Analogs: Design, Synthesis, Biological Evaluation and In Silico Studies
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37. Promiscuous mechanisms underlie the antitumor effects of thalidomide analogs
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38. Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon
    Sarah Engle, Justin J. Crowder, Sheldon G. Watts, Christopher J. Indovina, Samuel Z. Coffey, Eric M. Rubenstein · 2017 · PeerJ
39. Effects of cereblon on stress-activated redox proteins and core behavior
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40. Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout
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41. An Acetyldegron Triggers CRBN to Take Down the “Q”
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42. Significance of Selective Protein Degradation in the Development of Novel Targeted Drugs and Its Implications in Cancer Therapy
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43. CRBN deletion enhances mitochondrial metabolism by stimulating mitochondrial calcium accumulation in non-small cell lung cancer
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44. Safety considerations for cereblon-recruiting targeted protein degraders
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45. Crystal structure of N-terminal degron-truncated human glutamine synthetase
    Min Fey Chek, Sun‐Yong Kim, Tomoyuki Mori, Hisayuki Kojima, Toshio Hakoshima · 2021 · Acta Crystallographica Section F Structural Biology Communications
46. Target Protein Localisation and Its Impact on PROTAC-Mediated Degradation
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47. The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis
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48. Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis
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51. Thalidomide – From a Banned Drug to Molecular Glues, PROTACs, and New Concepts in Drug Discovery
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52. E3 ubiquitin ligase components in GtoPdb v.2022.1
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53. E3 ubiquitin ligase components in GtoPdb v.2022.3
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54. E3 ubiquitin ligase components in GtoPdb v.2023.2
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57. Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity
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63. Peer Review #1 of "Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon (v0.1)"
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65. Peer Review #3 of "Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon (v0.1)"
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66. Synthesis of Novel Glutarimide Ligands for the E3 Ligase Substrate Receptor Cereblon (CRBN): Investigation of Their Binding Mode and Antiproliferative Effects Against Myeloma Cell Lines
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68. Crbn Deletion Enhances Mitochondrial Metabolism by Stimulating Mitochondrial Calcium Accumulation in Non-Small Cell Lung Cancer
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69. Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
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70. Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity
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78. Glutamine metabolism in health and disease
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