BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia +15 more·2017·Molecular Cell

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  12. Bromodomain Protein, BRD4, Contributes to the Regulation of Alternative Splicing
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  13. Trivalent PROTACs Enhance Protein Degradation Through Cooperativity and Avidity
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  16. Overcoming the Protective Effect of the Bone Marrow Microenvironment by Dual FLT3 and BET Inhibition in FLT3-ITD Acute Myeloid Leukemia
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  19. The 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry
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  20. Faculty Opinions recommendation of RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.
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  21. Faculty Opinions recommendation of BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.
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  22. Faculty Opinions recommendation of RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.
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  23. Faculty Opinions recommendation of The dTAG system for immediate and target-specific protein degradation.
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  25. Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation
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  26. A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation
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  63. BindingDB Entry 50015286: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
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  64. BindingDB Entry 50021782: Expanding the ligand spaces for E3 ligases for the design of protein degraders.
    BindingDB · 2025 · UC San Diego
  65. BindingDB Entry 50019285: Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.
    BindingDB · 2024 · UC San Diego
  66. BindingDB Entry 50017778: Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold.
    BindingDB · 2023 · UC San Diego
  67. BindingDB Entry 50016017: Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.
    BindingDB · 2023 · UC San Diego
  68. BindingDB Entry 50008588: Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
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  69. Targeted protein degradation in cancer: strategies for undruggable targets and progress towards clinical translation
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