BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia +15 more·2017·Molecular Cell
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- The extra-terminal domain drives the role of BET proteins in transcriptionIwona Pasionek, John B. Ridenour, Agnieszka Machowska, Magdalena Donczew, Michael T Kinter, Kevin A Boyd, Rafał Donczew · 2026 · Nucleic Acids Research
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- Trivalent PROTACs Enhance Protein Degradation Through Cooperativity and AviditySatomi Imaide, Kristin M. Riching, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole B. Trainor, Sarah D. Mahan, Nancy Murphy, Kwok-Ho Chan, Andrea Testa et al. · 2020 · ChemRxiv
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- Identification of clofibric acid as a SYVN1 ligand for PROTAC developmentWarren, Julia, MD, PhD, Anandarao Munakala, Keith D. Zientek, Kilsun Kim, Phillip A. Wilmarth, Ashok P. Reddy, Bingbing X. Li, Xiangshu Xiao · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Overcoming the Protective Effect of the Bone Marrow Microenvironment by Dual FLT3 and BET Inhibition in FLT3-ITD Acute Myeloid LeukemiaLauren Lee · 2019
- BETter together: exploiting BRD4-functions in transcription to inform rational combinationsFabio Savarese, Norbert Kraut · 2018 · Oncoscience
- BET mechanisms in cancerElizabeth Henderson, P. Filippakopoulos · 2020 · Elsevier eBooks
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- Faculty Opinions recommendation of RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.Yamini Dalal · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.Cheng‐Ming Chiang · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.Tatiana G. Kutateladze, Catherine A. Musselman · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of The dTAG system for immediate and target-specific protein degradation.Songon An · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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- Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activationViral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Benedict Schubert, Haiyang Yun, Sarah J. Horton, Shuchi Agrawal Singh, Patricia S. Haehnel et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex FormationMorgan S. Gadd, Marine C. Aublette · 2022 · Wiley eBooks
- Recurrent nuclear protein of the testis carcinoma of the submandibular gland treated with multimodality therapy: A case report and review of the literatureKaixin Guo, Chenggong Zeng, Hongyu Jiang, Wenhao Luo, Zijun Zhen, Yujie Liang · 2023 · Pediatric Hematology Oncology Journal
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- Rational Design of CDK12/13 and BRD4 Molecular Glue DegradersZhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Katherine A. Donovan, Brendan G. Dwyer, Abby M. Thornhill, Hannah M. Jones, Zixuan Jiang, Xijun Zhu, Eric S. Fischer et al. · 2025 · Angewandte Chemie
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- BRD2 bridges TFIID and histone acetylation to promote transcriptional initiationBin Zheng, Ruxuan Qiu, Sarah R. Gold, Marta Iwanaszko, Yuki Aoi, Benjamin Charles Howard, Madhurima Das, Ali Shilatifard · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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- Additional file 1 of BRD4 is involved in viral exacerbation of chronic obstructive pulmonary diseaseDuan, Yifei, Zhou, Siyi, Wang, Jianmiao · 2023 · Figshare
- Additional file 5 of GeneWalk identifies relevant gene functions for a biological context using network representation learningRobert Ietswaart, Benjamin M. Gyori, John A. Bachman, Peter Karl Sorger, L. Stirling Churchman · 2021 · Figshare
- Additional file 1 of GeneWalk identifies relevant gene functions for a biological context using network representation learningRobert Ietswaart, Benjamin M. Gyori, John A. Bachman, Peter Karl Sorger, L. Stirling Churchman · 2021 · Figshare
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- FragLite mapping to identify the BRD4 recruitment site of P-TEFbIan Hope, Richard Heath, Arnaud Baslé, Mathew P. Martin, Michael J. Waring, Jane Endicott, Martin E. M. Noble, Natalie J. Tatum · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
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- Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4Simona Capponi, Sandra Ehret, Zeynep Camgöz, Fabian Gather, Christine A. Vaine, Ezgi Ozyerli‐Goknar, Marie Follo, D. Cristopher Bragg, Tanja Vogel, H. T. Marc Timmers · 2026 · Nature Communications
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- BindingDB Entry 50015286: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50021782: Expanding the ligand spaces for E3 ligases for the design of protein degraders.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50019285: Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50017778: Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold.BindingDB · 2023 · UC San Diego
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- BindingDB Entry 50008588: Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.BindingDB · 2021 · UC San Diego
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