Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Fanning, Saranna, Haque, Aftabul, Imberdis, Thibaut, Baru, Valeriya, Barrasa, M. Inmaculada, Nuber, Silke, Termine, Daniel, Ramalingam, Nagendran +23 more·2019·Molecular Cell
Cited by (297)
Items 201–297 of 297
- Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesisWalid Idi, Razan Sheta, Abid Oueslati · 2025 · Frontiers in Molecular Neuroscience
- Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseasesJayashankar Jayaprakash, Solomon Tebeje Gizaw, Divyavani Gowda, Hiroshi Hinou, Nishimura Si, Shu‐Ping Hui, Siddabasave Gowda B. Gowda · 2026 · Frontiers in Aging Neuroscience
- Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteinsClaudia Fokken, Ivan Silbern, Orr Shomroni, Kuan‐Ting Pan, Sergey Ryazanov, Andrei Leonov, Nadine Winkler, Henning Urlaub, Christian Griesinger, Dorothea Becker · 2024 · Melanoma Research
- Mitochondrial Dysfunction in Parkinson’s Disease: Is Impaired Deuterium Depleted Nutrient Supply by Gut Microbes a Primary Factor?Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos · 2025 · Biocell
- Brain lipidomics identifies mitochondrial redox dysfunction and metabolic trade-offs associated with Parkinson's disease-like pathology induced by Nanoplastics exposurePriya Rathor, Ashutosh Tiwari, Rajendra P. Patel, Anoop Kumar Verma, Sheelendra Pratap Singh, Ratnasekhar Ch · 2026 · Free Radical Biology and Medicine
- Overexpression of α-synuclein in Pigment Dispersing Factor neurons alters sleep–wake pattern by regulating lipid metabolism in DrosophilaDong Xia, Ying Chen, Xiang Fu, Huiyi Liu, Mu-Yan Sun, Fen Wang, Yong Zhang, Chun‐Feng Liu, Junyi Liu · 2024 · SLEEP
- A Multimodal Omics Exploration of the Motor and Non-Motor Symptoms of Parkinson’s DiseaseFrançois‐Xavier Lejeune, Farid Ichou, Etienne Camenen, Benoît Colsch, Florence Mauger, Caroline Peltier, Ivan Moszer, Emmanuel Gilson, Morgane Pierre‐Jean, Édith Le Floch et al. · 2022 · International Journal of Translational Medicine
- A non-canonical lipid droplet metabolism regulates the conversion of alpha-Synuclein to proteolytic resistant forms in neurons of a Drosophila model of Parkinson diseaseVictor Girard, Florence Jollivet, Oskar L. Knittelfelder, Jean-Noël Arsac, Gilles Chatelain, Daan M. van den Brink, Thierry Baron, Andrej Shevchenko, Nathalie Davoust, Bertrand Mollereau · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- α-Synuclein Activates the PI3K/AKT Pathway to Drive Lipid Droplets Accumulation: Implications for Parkinson’s DiseaseSuaad Abd Elhadi, Jenna Congdon-Loeffler, Eva Harrosch, Dima Khatib, Lama Naamneh, Meir Schechter, Alexandra Eliassaf, Ori Shalev, Ronit Sharon · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Lipid Alterations and Pathogenic Roles in SynucleinopathiesEstela Área-Gómez, Saranna Fanning, Ulf Dettmer · 2025 · Cold Spring Harbor Perspectives in Medicine
- Glycerol 3-phosphate acyltransferase exacerbates α-synuclein-induced toxicity by increasing lipid peroxidationMengda Ren, Grace Gui-Yin Lim, Willcyn Tang, Kah‐Leong Lim · 2026 · Nature Communications
- Lipid droplets in neurodegenerative diseases: pathological drivers and therapeutic vulnerabilitiesOurania Papapanagiotou, Kian Cotton, Christopher Edwards, David Michod, Lucy Crompton, Tim J. Craig, Maria Victoria Niklison-Chirou · 2026 · Cell Death Discovery
- Small Molecule Improvement of Trafficking Defects in Models of NeurodegenerationA. Katherine Hatstat, Michael D. Pupi, Michaela C. Reinhart, Dewey Granville McCafferty · 2021 · ACS Chemical Neuroscience
- Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutationAlmudena Maroto Juanes, Thomas Vogels, Sascha Koppes-den Hertog, Maarten Loos, Dieter Lütjohann, Martin A. Giera, Rik van der Kant · 2025 · Journal of Lipid Research
- Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairmentYi Wang, Yuning Li, Yakun Gu, Wei Ma, Yuying Guan, Mengyuan Guo, Qianqian Shao, Xunming Ji, Jia Liu · 2024 · Neural Regeneration Research
- Lower prevalence of metabolic syndrome and its components in the prediagnostic phase of Parkinson’s diseaseHila Avisar, Uri Greenbaum, Ruth Djaldetti, Boaz Lerner · 2025 · npj Parkinson s Disease
- Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeastDaeun Noh, Robert W. Newberry · 2026 · Protein Science
- Comprehensive lipidomics reveal Rotenone exposure induces redox-driven lipid droplet accumulation, systemic lipidome perturbation and differential metabolic prioritization linked to Parkinson’s diseaseAshutosh Tiwari, Priya Rathor, Rajendra P. Patel, Pawan Kumar Jha, Nicholas Birse, Ratnasekhar Ch · 2026 · NeuroToxicology
- Spatial lipidomics identifies α-synuclein-induced lipid changes in an AAV-induced Parkinsonian mouse modelYachao He, Ibrahim Kaya, Xiaoqun Zhang, Anna Nilsson, Li Cao, Per E. Andrén, Per Svenningsson · 2026 · Neurobiology of Disease
- Combined toxicity prediction of deoxynivalenol and fumonisin B1 by physiologically based toxicokinetic modelling and in vitro toxicity mechanism study on astrocyte-like C6 cellsXinlu Wang, Liuqing Wang, Haoran Wu, Bingxu Yao, Meng Wang · 2026 · Journal of Hazardous Materials
- Lipid membrane remodeling by myristic acid treatment reverses Parkinson’s disease α-synuclein phenotypes in patient neuronsJulián Ávila-Pacheco, Gleidia Sauli, Luis Fonseca‐Ornelas, Haley Cirka, Deepa Kumari, Morgan Hazo, Sarah Jeanfavre, Pedro H. Vendramini, Christina Muratore, Clary B. Clish et al. · 2026 · npj Metabolic Health and Disease
- OLHA (N-oleoylhistamine) modulates activity of mouse brain histaminergic neuronsOlga A. Sergeeva, Karolina Mazur, David Reiner‐Link, Kiril Lutsenko, Helmut L. Haas, Mercedes Alfonso‐Prieto, Holger Stark · 2022 · Neuropharmacology
- Pathophysiology and Management Approaches for Parkinson’s DiseaseSabiya Samim Khan, Padmashri Naren, Poojitha Pinjala, Sai Nikhil Uppala, Shashi Bala Singh, Dharmendra Kumar Khatri · 2023 · Springer eBooks
- Fatty acids as potential biomarkers of stearoyl-CoA desaturase inhibition: Variation in healthy subjects and Parkinson's disease patientsPepijn P.N.M. Eijsvogel, Andriy A. Gorbenko, Daniel F. Tardiff, Michelle Skupien, Ken Rhodes, Robert H. Scannevin, Yalçin Yavuz, Emilie M.J. van Brummelen, Brigitte Robertson, Philip H. C. Kremer et al. · 2025 · Biomarkers in Neuropsychiatry
- Metabolomics and biochemical alterations caused by pleiotrophin in the 6-hydroxydopamine mouse model of Parkinson’s diseaseEsther Gramage, Jorge Sáiz, Rosalía Fernández‐Calle, Yasmina B. Martín, María Uribarri, Marcel Ferrer‐Alcón, Coral Barbas, Gonzalo Herradón · 2022 · Scientific Reports
- A small molecule screen for paqr-2 suppressors identifies Tyloxapol as a membrane fluidizer for C. elegans and mammalian cellsMario Ruiz, Emma Svensk, Elinor Einarsson, Erik Podda Grahn, Marc Pilon · 2022 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- α-Synuclein Aggregates and Parkinson's diseaseIsadora Cucolo Oliveira, Tárik Abdalla dos Santos, Ian Vilas Boas Covizzi, Thatiana Scalon, João Renato Villas Bôas, Frans Eberth Costa Andrade, Alba Regina de Abreu Lima, Sheila Adami Vayego, Uderlei Doniseti Silveira Covizzi · 2024 · Seven Editora eBooks
- Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial DysfunctionTao Zhang, María Eugenia Goya, Alejandro Herrón-Bedoya, Jorien C. van der Weerd, Dikaia Tsagkari, Suzanne Couzijn, Lale Güngördü, Renée I. Seinstra, Margaretha Rebecca Heiner-Fokkema, Ming Chang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like CellsKhushbu Kabra, Dallin Dressman, Ryan Talcoff, Maedot Yidenk, Olivia M. Rifai, Benjamin N. Hoover, Neil A. Shneider, Wassim Elyaman, Estela Área-Gómez, Elizabeth M. Bradshaw · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain lengthDominika Hajdúchová, Roman Holič, Peter Gajdoš, Milan Čertík, Erika Halášová, Renata Péčová, Michal Pokusa · 2022 · General Physiology and Biophysics
- Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevationZifeng Huang, Hui Zhong, Yiyu Lu, Ruoyang Yu, Muwei Zhang, Jialing Zheng, Bin Xiao, Zhidong Zhou, Yinghua Yu, Chao Deng et al. · 2025 · Neurotherapeutics
- Elevation of Stearoyl‐Coenzyme A Desaturase and Monounsaturated Fatty Acids in Parkinson's Disease SerumFinula I. Isik, Russell Pickford, Michelle Chua, Simon J. G. Lewis, Nicolas L. Dzamko, Woojin Scott Kim · 2026 · Movement Disorders
- Multi-omics reveal phosphatidic acid phosphatases modify Niemann-Pick type C disease severityAndrew B. Munkacsi, Gabriella E. Conway, Keri Multerer, Michael D. Jackson, Lauren S. Csaki, Tamayanthi Rajakumar, Jeffrey P. Sheridan, Eliatan Niktab, Wuh‐Liang Hwu, Yin‐Hsiu Chien et al. · 2026 · iScience
- Membrane Fluidity Regulation: From C. elegans to mammalian cellsRanjan Devkota · 2020 · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Diagnostics of Parkinson’s disease by positron-emission tomography with 18F-DOPA: new approach based on smart clusteringKsenia O. Tutsenko, A A Horoshavina, V A Abramov, Карлова Елена Анатольевна, Michael G. Sadovsky · 2020 · Journal of Physics Conference Series
- Unsaturated fatty acids profiling in live C. elegans using real-time NMR spectroscopyBruno Hernández Cravero, Gastón Prez, Verónica A. Lombardo, Andrés Binolfi, Diego de Mendoza · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Lipidomics Reveals Glycerophospholipid Metabolism Dysregulation in the Corpus Striatum of Mice Treated with CefepimeXiaocong Liu, Xiaojie Wang, Qingfan Wei, Xiaowei Yang, Jiamei Zhang, Rui Xu, Haoluo Zhang, Shaomin Wang, Xuemei Wan, Linhong Jiang et al. · 2021 · Research Square
- Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synucleinCharlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, Laura A. Volpicelli‐Daley · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Transmembrane helices mediate the formation of a stable ternary complex of cyt b 5 reductase, cyt b 5 , and SCD1Jiemin Shen, Gang Wu, Ah‐Lim Tsai, Ming Zhou · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Profiling Membrane Lipids in C. elegans Models of Parkinson’s DiseaseKetaki A. Mahurkar · 2020
- Serum phosphorylated α-synuclein: A potential biomarker of poststroke cognitive impairmentYi Wang, Yuning Li, Yakun Gu, Wei Ma, Yuying Guan, Mengyuan Guo, Qianqian Shao, Xunming Ji, Jia Liu · 2023 · Research Square
- Seeing the Action of Lipid Droplets in Aging and LongevityBo Tao, Hongyuan Yang, Rong Fan · 2023 · GEN Biotechnology
- Lipid metabolism in neurodegenerative diseasesJeroen F. J. Bogie, Jeroen Guns, Sam Vanherle · 2023 · Elsevier eBooks
- The role of polyunsaturated fatty acids: The possibility of diet intervention in Parkinson's diseaseHaoan Tang, Shaojia Chen, Hongjun Liu, Xu Chen · 2023 · MEDS Public Health and Preventive Medicine
- Genetic Associations of Lipid-Lowering Drugs and Parkinson’s Disease: A Mendelian Randomization StudyLin Shen, Yifan Yang, Yi Li, Hok Leong Chin, Helen Ye Rim Huang, Bernard M.Y. Cheung, Gary Tse, Oscar Hou In Chou, Jiandong Zhou · 2024 · medRxiv
- Age-related energetic reprogramming in glial cells: possible correlations with Parkinson’s diseaseBoling Chu, Hongling Xiang, Han Wang, Yu-Ting Lin, Rui Li, Jing Rong Hu, Hao Qian · 2024 · Ageing and Neurodegenerative Diseases
- Cellular Fibronectin Exacerbates Α-Synuclein Aggregation via Integrin Alpha4beta1 Mediated PARP1 and SCD ElevationZifeng Huang, Muwei Zhang, Hui Zhong, Jialing Zheng, Ruoyang Yu, Bin Xiao, Zhidong Zhou, Yinghua Yu, Chao Deng, Kunlin Jin et al. · 2024 · SSRN Electronic Journal
- A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative DiseaseHimangi Vig, Priyanka Shukla, Anamika Mishra, Ayushi Pal, Ankita Wal · 2024 · Central Nervous System Agents in Medicinal Chemistry
- The combination of optogenetic-induced protein aggregation and proximity biotinylation assays strongly implicates endolysosomal proteins in the early stages of α-synuclein aggregationMaxime Teixeira, Razan Sheta, Dylan Musiol, Vetso Ranjakasoa, Jérémy Loehr, Jean‐Philippe Lambert, Abid Oueslati · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Mass Spectrometry-Based Methods in CNS Drug DiscoveryGonzalo Blasco, Rudy Schreiber, Daan van Kruining · 2024 · Springer eBooks
- Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synucleinMagdalena M. Bolsinger, Tim E. Moors, Lisa Brontesi, Silke Nuber, Ulf Dettmer, Nagendran Ramalingam · 2025 · Metabolic Brain Disease
- Stearoyl–coenzyme A desaturase enhances cell survival in human uterine leiomyomaAllison S. Komorowski, John Sayler Coon, Melania Lidia Anton, Azna Zuberi, Olivia Sotos, Serdar Ekrem Bulun, Ping Yin · 2025 · F&S Science
- Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysisXiude Qin, Yuerong Li, Qian Cai, Jiaye Liu, Zhao-Hui Dang, Liling Li, Jia‐Wei Min, Shaohua Qi, Fan Bu · 2025 · Frontiers in Genetics
- Perilipin 4 Repetitive Region Forms Amyloid Fibrils Promoted by a Genetic Expansion Found in Myopathy PatientsCharbel Choufani, Nicolas Fuggetta, Cyril Moulin, Bayane Sabbagh, Céline Franckhauser, Sébastien Lyonnais, Ana‐Andreea Arteni, Sylvie Rouquier, Tinkara Perme, Sophie Pagnotta et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- A guide to selecting high-performing antibodies for Stearoyl-CoA desaturase (SCD1) (UniProt ID: O00767) for use in western blot, immunoprecipitation, and immunofluorescenceVera Ruíz Moleón, Charles Alende, Maryam Fotouhi, Sara González Bolívar, Riham Ayoubi, Carl Laflamme, NeuroSGC/YCharOS/EDDU collaborative group · 2025 · F1000Research
- In vivo inhibition of stearoyl-CoA desaturase modulates the hippocampal fatty acid profile and restores density of dendritic spines in the aggressive 5xFAD model of Alzheimer’s diseaseMarta Turri, Myriam Aubin, Anne Aumont, Annick Vachon, Jessica Avila Lopez, Marian Mayhue, Mélanie Plourde, Karl J. L. Fernandes · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- NPAS2 attenuates VSMC phenotypic switching in ascending thoracic aortic aneurysm via LPCAT3/PC-PUFA2S-mediated ferroptosisWenfeng Lin, Jiaqi Xiong, Yuhan Yan, Jinhui Bian, Zhen Zhang, Xinyang Xu, Yifei Diao, Xiaoxia Lan, Yu Zhong, Haibin Ji et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Integrative lipidomics of brain and plasma uncovers sex-specific metabolic signatures in Parkinson’s diseaseUnnati Agrawal, Priya Nataraj, Aakash Chandramouli, Syam Krishnan, Siddhesh S. Kamat, Madhusoodanan Urulangodi, Poonam Singh Thakur · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 3 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 6 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 1 of APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoidsZhao, Jing, Tadafumi C. Ikezu, Wenyan Lü, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis‐Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann et al. · 2023 · Figshare
- Additional file 9 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 1 of Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synucleinBeal, M. Flint, Jayandra Chiluwal, Noel Ylagan Calingasan, Ginger L. Milne, Mikhail S. Shchepinov, Vı́ctor Tapias · 2020 · Figshare
- Additional file 1 of Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brainFu, YuHong, He, Ying, Katherine Phan, Surabhi Bhatia, Russell Pickford, Wu, Ping, Dzamko, Nicolas, Glenda M. Halliday, Woojin Scott Kim · 2022 · Figshare
- Additional file 1 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 2 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 4 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 11 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 5 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 7 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 12 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 8 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 10 of Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s diseaseLiu, Mei, Zhao, Jinlan, Xue, Chengcheng, Yang, Jun, Ying, Li · 2024 · Figshare
- Additional file 1 of Association of serum oleic acid level with depression in American adults: a cross-sectional studyJiahui Yin, Li, Siyuan, Li, Jinling, Rongpeng Gong, Jia, Zhixia, Liu, Junjun, Jin, Zhi, Yang, Jiguo, Liu, Yuanxiang · 2023 · Figshare
- SREBP1-driven SCD1 protects retinal pigment epithelium from oxidative damage by activating the NRF2/GPX4 axisXingyu Yang, Weichen Xu, Hang Xie, Xiaoyu Guo, Feiyan Zhu, Yiqiao Xing, Changzheng Chen · 2026 · Experimental Eye Research
- Membrane-associated intrinsically disordered regions: dual roles in binding and membrane protein functionLéa Poskin, Hugo Bâlon, Tanguy Leyder, Catherine Michaux, Julien Mignon · 2026 · Critical Insights in Biophysics
- From mice to clinical relevance: humanizing neuroscience with human-based model systemsAniella Bak, Karen M. J. van Loo, Deborah Kronenberg‐Versteeg, Henner Koch · 2026 · Frontiers in Cellular Neuroscience
- Causal relationships between plasma lipidomics, trace elements, cerebrospinal fluid metabolites, and Parkinson's disease using Mendelian randomizationMengqi Wang, Mengshuang Huang, ZhaoMing Chen, Shengjie Gou, Chao Ma, Linglong Xiao · 2026 · Brain Research Bulletin
- Étude de la propagation prion-like de l'alpha-synucléine dans des réseaux de neurones reconstruitsJosquin Courte · 2019 · theses.fr (ABES)
- Study of the interactions between the nervous system and the gut in Parkinson’s disease using DrosophilaXiaojing Yue · 2022 · theses.fr (ABES)
- Etude des besoins en stérols des souches de levures œnologiques (Saccharomyces Cerevisiae)Giovana Girardi Piva · 2022 · theses.fr (ABES)
- The Emerging Parkinson's Disease Oxylipin‐OmeJulia C. Kelliher, Saranna Fanning · 2026 · Advanced Science
- Mutational Scanning of α-Synuclein using a Clickable Protein Tag Reveals Determinants of Membrane-Induced AggregationDaeun Noh, Robert W. Newberry · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Systemic ELOVL6 activity predicts survival and represents a modifiable target of ALSAndrés Jiménez-Zúñiga, Gorka Fernández‐Eulate, José Ignacio Ruiz-Sanz, Jose Luis Zúñiga-Elizari, Maddi Garciandia-Arcelus, Javier Riancho, Rubén Jara Rubio, Ahmad Al Khleifat, Mónica Zufiría, Sonia Alonso‐Martín et al. · 2026 · medRxiv
- Astrocytic ACSBG1 depletion improves lipid-cytokine signaling and attenuates α-Synuclein pathology in a Parkinson’s disease mouse modelYoung Doo Kim, Bhupesh Vaidya, Jiyoen Kim, Sara Bitar, Femil Joseph Shajan, Ajay Kumar Verma, Hari Krishna Yalamanchili, Shubham Singh, Huda Yahya Zoghbi · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Deconvolving the structural heterogeneity of alpha-Synuclein in vitro and in situLiliana Malinovska, Alexandra Malinovska, Yuehan Feng, Lynn Verbeke, Pratibha Kumari, José D. Camino, Valentina Cappelletti, Sonja Kroschwald, Elisa Dultz, Meltem Tatlı et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spinesGisela Besa-Selva, Esther García-García, Alba Ramón-Lainez, Geòrgia Escaramís, Pol Garcia‐Segura, Cristina Malagelada, Eulàlia Martı́, Jordi Alberch, Mercè Masana, Manuel José Rodríguez · 2026 · BMC Biology
- Chronic α-Synuclein Over-Expression and Ceruloplasmin Challenge Promote Distinct Iron and Redox Responses in M17 CellsMasoumeh Pourhadi, Bedri Ranxhi, Seth P Sukaria, Fatimah H Hussein, Sokol V. Todi, Peter A. LeWitt, Wei‐Ling Tsou · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Unlocking Parkinson’s disease: harnessing the untapped potential of fatty acid metabolism in disease pathogenesisRong Hu, Yaru Song, Ting Liu, Xinyu He, Yi-Yong Qiu, Fanjing Zhong, Xiao Huang, J.J. Huang, Zhigang Jiao · 2026 · Frontiers in Immunology
- Age-dependent changes in lipid droplet distribution and vascularization in naked mole rat vs. mouse hippocampusLiv S Krogstad, Markus Augustin Teppen, Harald S Mjønes, Jonathan Richard Brewer, Thomas J. Park, Samuel J. Geiseler, Cecilie Morland · 2026 · GeroScience
- Condensate-driven triglyceride reduction links α-synuclein to mitochondrial dysfunctionTao Zhang, Alejandro Herrón-Bedoya, María Eugenia Goya, Jorien C. van der Weerd, Dikaia Tsagkari, Suzanne Couzijn, Lale Güngördü, Anna P. Ainslie, Renée I. Seinstra, Margaretha Rebecca Heiner-Fokkema et al. · 2026 · EMBO Reports
- Cellular and systemic modifiers of alpha-synuclein proteostasisSuzanne Couzijn, Anna P. Ainslie, Alejandro Herrón-Bedoya, Ellen A. A. Nollen · 2026 · Philosophical Transactions of the Royal Society B Biological Sciences
- Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's diseaseYuyuan Lin, Yu Yu, Keren Zhang, Irish Del Rosario, Aline Duarte Folle, Elizabeth Rose Mayeda, Dean P. Jones, Douglas I. Walker, Jeff M. Bronstein, Adrienne M. Keener et al. · 2026 · Alzheimer s & Dementia
- α-Synuclein pathology induces conserved lipid acyl-chain remodeling across mouse brain and human dopaminergic neuronsElisabeth Dinter, Éva M. Szegő, Hella Luksch, Lennart Höfs, Björn H. Falkenburger · 2026 · Research Square
- From dosage alteration to amplification strategies: mechanistically defined alpha-synuclein mouse models for Parkinson’s disease therapy developmentSilke Nuber, Saranna Fanning, Ulf Dettmer · 2026 · Acta Neuropathologica
- Metabolic endotyping for mechanism-informed Alzheimer’s and Parkinson’s disease trialsJosé A. Santiago, Olivier Rascol, Tom Foltynie, Wassilios G. Meissner, Judith A. Potashkin, Jean C. Gutierrez-Silva, Mohammad Nafeli Shahrestani, Yusen Wu, Tatjana Rundek, Ihtsham Ul Haq · 2026 · Med
- APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamicsCuní-López, Carla, Root, Jessica T., Hao, Ying, Blomberg, Niek, Koppes-den Hertog, Sascha J., Sacks, Dylan, Trujillo, Amber E., Ghirlando, Rodolfo, Kowal, Isabelle, Epstein, Jacob et al. · 2026 · Nature Communications