Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Fursova, Nadezda A., Blackledge, Neil P., Nakayama, Manabu, Ito, Shinsuke, Koseki, Yoko, Farcas, Anca M., King, Hamish W., Koseki, Haruhiko +1 more·2019·Molecular Cell
DOI 10.1016/j.molcel.2019.03.024

Cited by (253)

Items 201–253 of 253

  1. MicroRNA-770 promotes polarization of macrophages and hemorrhoids by suppressing RYBP expression and monoubiquitination of histone H2A on Lys119 modification
    Haikun Zhou, Te Liu, Shenglan Zhong, Wei Yang · 2025 · Molecular Immunology
  2. Unconventional structure and function of <scp>PHD</scp> domains from additional sex combs‐like proteins
    Reddington, Cameron J., Walsh, Annabel R., Kleffmann, Torsten, Göbl, Christoph, Mace, Peter D. · 2025 · The FEBS Journal
  3. PRC1 uncomplexed
    Sanne Schouten, Nick G.P. Bovee, Zicong Liu, Hendrik Marks · 2022 · Stem Cell Reports
  4. Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator
    María Mariner-Faulí, Víctor Sánchez-Gaya, Sarah Malika Robert, Patricia Respuela, Sara Cruz-Molina, Sara Lobato-Moreno, Matteo Trovato, Karin D. Prummel, Kyung‐Min Noh, Judith B. Zaugg et al. · 2026 · Nucleic Acids Research
  5. Histone demethylome map reveals combinatorial gene regulatory functions in embryonic stem cells
    Yogesh Kumar, Pratibha Tripathi, Pushkar Dakle, Majid Mehravar, Varun K. Pandey, Michael J. Bullen, Zhongming Zhang, Dhaval Hathiwala, Marc A. Kerenyi, Andrew J. Woo et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Fighting PRC1 via the RING
    Joshua P. Plotnik · 2021 · Nature Chemical Biology
  7. Polycomb Repressive Complexes occupancy reveals PRC2-independent PRC1 critical role in the control of limb development
    Fanny Guerard-Millet, Claudia Gentile, Racheal Paul, Alexandre Mayran, Marie Kmita · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Endogenous retrovirus-driven Pcgf5 plays critical roles in zygotic genome activation and noncanonical imprinting
    Satoshi Mashiko, Takuto Yamamoto, Naojiro Minami, Shuntaro Ikeda, Shinnosuke Honda · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  9. SET1/MLL complexes control transcription independently of H3K4me3
    Ho Yu Alan Au, Aleksander Szczurek, Inge de Krijger, Nianna Kjelstrup-Osorio, Amy L. Hughes, Anna Lastuvkova, Michiel Vermeulen, Robert J. Klose · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  10. SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation
    Takashi Kondo, Shinsuke Ito, Junichiro Takano, Yong-Woon Han, Takaho A. Endo, Kaori Kondo, Marika Shibata, Yusuke Kawashima, Hiroki Sugishita, Mio Harachi et al. · 2025 · Molecular Cell
  11. Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity
    Jinwen Kang, Peiyao Liu, Shoko Ichimura, Lauryn Cook, Mengwen Hu, Satoshi H. Namekawa, Zhiyuan Chen · 2026 · Nature Communications
  12. H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
    Hailiang Mei, Chisayo Kozuka, Mami Kumon, Haruhiko Koseki, Azusa Inoue · 2026 · Molecular Cell
  13. BAP1 activity regulates PcG occupancy and global chromatin condensation counteracting diffuse PCGF3/5-dependent H2AK119ub1 deposition
    Eric Conway, Federico Rossi, Simone Tamburri, Eleonora Ponzo, Karin Johanna Ferrari, Marika Zanotti, Daniel Fernández-Pérez, Daria Manganaro, Simona Rodighiero, Diego Pasini · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  14. A previously-unrecognized motif of transcription factor RYBP, hotspot of cancer-related mutations, is essential for the integrity of Polycomb repressive complex 1
    Catarina S. Silva, Laura Mariño, Irene Garcia Ferrer, Ines Dieryck, Ombeline Pessey, Elisabetta Boeri Erba, Malene Ringkjøbing Jensen, Marco Marcia · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Epigenetic control of coordinated hematopoietic and cardiovascular development by Rnf2 in zebrafish
    XX Peng, Gang Feng, YH Sun · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  16. フリーター五右衛門(2)コガネムシの羽音
    昌典 神田 · 2005 · 文蔵
  17. MDM2 as a chromatin modifier
    Sabrina Gerber · 2020
  18. Age-dependent transcriptional and epigenetic alterations in mouse hepatocytes
    Sharma, Ankur · 2021
  19. Analysis of Polycomb Repressive Complexes binding dynamics during limb development reveals the prevalence of PRC2-independent PRC1 occupancy
    Claudia Gentile, Alexandre Mayran, Fanny Guerard-Millet, Marie Kmita · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  20. In This Issue
    2022 · Blood Cancer Discovery
  21. An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma
    Nezha S. Benabdallah, Vineet Dalal, Afroditi Sotiriou, R. Wilder Scott, Felix K. F. Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J. Sánchez Rivera, Monica Ta et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Data from Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death
    Lucia Cottone, Adam P. Cribbs, Garima Khandelwal, Graham Wells, Lorena Ligammari, Martin Philpott, Anthony Tumber, Patrick Lombard, Edward S. Hookway, Tamás Szommer et al. · 2023
  23. Loss of RNF2 delays tumour development in BAP1-deficient mesothelioma
    Nick Landman, Danielle Hulsman, Jitendra Badhai, Maarten van Lohuizen · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  24. PRC1 Protein Subcomplexes Architecture: Focus on the Interplay between Distinct PCGF Subunits in Protein Interaction Networks
    Nayla Munawar, Kieran J. Wynne, Giorgio Oliviero · 2024 · International Journal of Molecular Sciences
  25. PIC-king apart PRC1-mediated repression
    Evan Healy, Adrian P. Bracken · 2024 · Trends in Genetics
  26. Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer
    Janith A. Seneviratne, Clare L Crisp, Eleanor Glancy, Natalie Choy, Winnie Tan, Matthew Neve, Melanie Stammers, Tongtong Wang, Ruby Johnstone, Arshnoor Kaur et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Lysosome-like structures in the nucleolus mediate H2Aub degradation under glucose starvation
    Jinli Jin, Senyu Ma, Jing Shi, Hanghang Lou, Yunxiao Li, Yao Yao, Na Fang, Yuqi Liu, Lu Yang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  28. H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain
    Lucy Anne Doyle, Alexandra Derrien, Dipta Sengupta, Firuze Ünlü Bektaş, Jennifer Lawson, Chinmayi Pednekar, Alex von Kriegsheim, Ian R. Adams, Robert Scott Illingworth · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  29. RNF2 Missense Variants Disrupt Polycomb Repression and Enable Ectopic Mesenchymal Lineage Conversion During Human Neural Differentiation
    Stephanie L. Bielas, Charles W. Ryan, Samantha L. Regan, Jason Sheingold, Anupam Goswami, Maureen Mulhern, Jonathan M. Ploeger, Samuel J. Huang, Verity L. Hartill, Alyssa L. Rippert et al. · 2025 · Research Square
  30. AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma
    Daniel Angelov, James Nolan, Gráinne Holland, Darragh Nimmo, Molly Davies, Craig Monger, Eugène Dillon, Marlena Mucha, Cheng Wang, Dáire Gannon et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Polycomb Repressive Complexes 1 and 2 are recruited independently to pericentromeric heterochromatin in response to hypomethylation in mouse embryonic stem cells
    Silviya Dimova, Olga Stepanova, David Hay, Katherine E. Pickup, Philippe Emmanuel Gautier, Laura C. Murphy, Yatendra Kumar, Ian R. Adams, Sari Pennings, Richard R. Meehan · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  32. RepID promotes metastatic potential in osteosarcoma through regulation of the PRC1-GATA6 axis
    Dong-Hyun Jung, Jong-Uk Park, Jae-Hyun Jo, Dong‐Kyu Kim, Yeong-Mu Kim, Min Ju Kang, Suk-Hoon Hong, Hyo Je Cho, Jihoon Nah, Jun-Young Park et al. · 2025 · Animal Cells and Systems
  33. The RING1 subunit of Polycomb Repressive Complex 1 monoubiquitinates histone H2A and mediates repression independently of Polycomb Repressive Complex 2 in the model diatom Phaeodactylum tricornutum
    Yue Wu, Xue Zhao, Jiong Chen, Timothée Chaumier, Leı̈la Tirichine · 2025 · New Phytologist
  34. Analysis of Polycomb Repressive Complexes binding dynamics during limb development reveals the prevalence of PRC2-independent PRC1 occupancy
    Marie Kmita · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  35. BRD4 represses developmental and neuronal genes through interaction with PRC1.6
    Fanny Boulet, Manthan Patel, Zeinab Shadman Zanjani, Nuria Andrés-Sánchez, Anam Ijaz, Debosree Pal, Pankaj Dubey, Aoife Murray, Dean Nižetić, Michael D. LeClaire et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  36. PCGF1 is a key factor for facilitating dynamic H3K27me3 modification during early lineage specification
    Pan Chen, Xuejie Yang, Ruhai Chen, Hanlu Li, Jingwen Ma, Jing Chang, Guangliang Hong, Wei Liu, Xiongzhi Quan, Bin Yin et al. · 2026 · 中国科学通报：英文版
  37. A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
    Thomas Balan, Ambre Petitalot, Julien Richard Albert, Louise Abbou, Guillaume Chevreux, Bassem Al‐Sady, Bihter Özdemir Aygenli, Till Bartke, Raphaël Margueron, Sandra Duharcourt · 2026 · Genome biology
  38. Méthylation de l'ADN : fonctions et ciblage au cours du développement chez la souris
    Thomas Dahlet · 2019 · theses.fr (ABES)
  39. Nuclear mTOR-Polycomb synergism at developmental gene promoters prone to activation
    Persia Akbari Omgba, Gunwant Patil, Maximilian Stötzel, Chieh-Yu Cheng, Henri Niskanen, Max Ruwolt, Aurora Elhazaz Fernandez, Neil P. Blackledge, Astrid Grimme, Fan Liu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Canonical and variant PRC1 functionally converge on PRC2 targets to regulate transcriptional programs during mouse limb development
    Claudia Gentile, Rachel Paul, Fanny Guerard-Millet, Gabriel Villiard, Christian Poitras, Alexandre Mayran, François Robert, Marie Kmita · 2026 · Proceedings of the National Academy of Sciences
  41. CREPAS: a reproducible nascent chromatin sequencing analysis pipeline for epigenome replication studies
    Samuel Ruiz‐Pérez, Qian Du, Alva Biran, Anja Groth, Nicolás Alcaraz · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  42. PCGF1-mediated bivalent promoter remodeling enables NK cell immune evasion in non-small cell lung cancer
    Hui Zhou, Hechun Lin, Yiru Kong, Hongyu Pan, Wenjun Chai, Lei Sun, Yu Wang, Mengxi Ge, Xiaoyu Ji, Rongrong Yao et al. · 2026 · Cell Death and Disease
  43. Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin
    Emma J. Doyle, Maeve Boyce, Sarah Buggle, Taylor Smith, Eugène Dillon, Anthony M. McElligott, Nina M. Orfali, Aisling Y. Coughlan, Diego Pasini, Eric Conway · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Citrullination in proteins of the polycomb repressor complex 1
    María Gabriela Álvarez-Rodríguez, Emanuel Capone, Sonia Vega, Virginia Rejas, Bruno Rizzuti, Adrián Velázquez‐Campoy, José L. Neira · 2026 · Archives of Biochemistry and Biophysics
  45. Single-cell transcriptomic and epigenomic analysis reveals X-linked sex differences in aging mouse hypothalamus
    Doudou Yu, Ilya Osipov, Lexi-Amber Hassell, Neta A Shwartz, Kaitlyn H. Hajdarovic, Harold Marin, Ashley E. Webb · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Developmentally programmed loss of long-range Polycomb interactions is regulated by cohesin
    Valeriia Smialkovska, Ann‐Kristin Dicke, Angelika Feldmann · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Capture-(Hi)C analysis with PostChicago: Integrative metaprofiling and quantitative comparison of chromatin interactions
    Samuel Krall, Belinda Blum, Valeriia Smialkovska, Ezo Oezcan, Sarah-Victoria Dachtler, Gaia Oldfield, Angelika Feldmann · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Dissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactions
    Miles K. Huseyin, Sumin Kim, Jack Toppen, Neil P. Blackledge, Anders S. Hansen · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  49. KMT2B facilitates long-range gene regulation through LINE1 elements
    Lara Zorro Shahidian, Lucio Di Filippo, Sarah Malika Robert, Álvaro Rada-Iglesias · 2026 · Nature Communications
  50. Epigenetic processes in neurodevelopmental disorders
    Elisa Ventura, Alessandro Sessa · 2026 · Handbook of clinical neurology
  51. Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions
    Yixuan Ren, Lei Yang, Boyi Fei, Rong Guo, Junran Huang, Zhenghao Xu, Ruoran Wang, Pinqi Zhang, Dandan Cao, Pan Chen et al. · 2026 · Science China Life Sciences
  52. FBRSL1 couples ncPRC1.3 to CoREST to repress cell-cycle genes during human neuronal differentiation
    Sanxiong Liu, Han-Wen Chang, Danny Reinberg · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  53. PCGF1/PRC1.1 selectively sustains astroglial lineage progression by repressing N4bp1 to stabilize Notch signaling
    Luyao Yin, Jiaqi Zhou, Ziqi Ma, Chunhui Wang, Mengjia Shen, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng · 2026 · EMBO Reports