Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
Mayor-Ruiz, Cristina, Jaeger, Martin G., Bauer, Sophie, Brand, Matthias, Sin, Celine, Hanzl, Alexander, Mueller, André C., Menche, Jörg +1 more·2019·Molecular Cell
Cited by (122)
Items 101–122 of 122
- E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug DevelopmentRafael M. Ioris, Katherine Ferris, Vincenzo D’Angiolella · 2022 · Wiley eBooks
- WITHDRAWN: Targeted protein degradation: A promising approach for cancer treatmentMuhammad Zafar Irshad Khan, Adila Nazli, Iffat Naz, Dildar Khan, Ihsan‐ul Haq, Jianzhong Chen · 2023 · Journal of Pharmaceutical Analysis · Retracted
- Targeted KRAS G12V degradation elicits efficient and durable lung adenocarcinoma regression in vivoAlberto J. M. Martín, Inés M. García-Pérez, Sonia San José, Pep Rojo, Carlos Riego‐Mejías, Cristina Teodósio, Bárbara M. G. Barbosa, Carolina Sánchez, Ignasi Folch-I-Casanovas, Antonia Odena Caballol et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilitiesJianfeng Ge, Shoko Hirosue, Saroor A. Patel, Ludovic Wesolowski, Anna Dyas, Cissy Yong, Leticia Castillon, Sanne de Haan, Jarno Drost, Grant Duncan Stewart et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- SCALLOPS: a scalable, integrated computational framework for Optical Pooled ScreensJoshua Gould, José Sergio Hleap, Ping Wu, Takamasa Kudo, Jane Guan, Anqi Zhu, Eric Lubeck, Xing-Yue M. Ge, Aaron Archer Waterman, Tommaso Biancalani et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- The 2nd Alpine Winter Conference on Medicinal and Synthetic ChemistryAlessio Ciulli, Lawrence G. Hamann, Wolfgang Jahnke, Amit S.S. Kalgutkar, Thomas Magauer, Tobias Ritter, Vicky Steadman, S. D. Williams, Georg E. Winter, Klemens Hoegenauer et al. · 2021 · ChemMedChem
- Faculty Opinions recommendation of Major Advances in Targeted Protein Degradation: PROTACs, LYTACs, and MADTACs.John A. Lowe III · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Rational discovery of molecular glue degraders via scalable chemical profiling.Stevan W. Djurić · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Strawberry COP9 signalosome FvCSN5A regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H 2 O 2 homeostasisYun Huang, Jia Gao, Guiming Ji, Wenjing Li, Jiaxue Wang, Qinghua Wang, Yuanyue Shen, Jiaxuan Guo, Fan Gao · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNAMahsa Shirani, Ronaldo Shaquille Bowie, Michael D. Tomasini, Ruth Hook, Denise Ng, Bassem Shebl, Barbara A. Lyons, Philip Coffino, Sanford M. Simon · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variantsJohannes W. Bigenzahn, F. Kartnig, Manuela Vollert, V. Sedlyarov, G. Superti-Furga · 2025 · bioRxiv
- PROTAC-Driven Protective Therapy increases the therapeutic window of anticancer drugsLucía Simón-Carrasco, Soledad Raya, Elena Pietrini, Manuel Luque-Perez, Marta del Rio Oliva, Ivan Rosado, Andres Joaquin Lopez-Contreras · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Dual Target E3 Ligase Ligands: A New Way to Overcome Drug Resistance相奕 潘 · 2026 · Hans Journal of Medicinal Chemistry
- Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic ApplicationsJiaye Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang · 2026 · MedComm – Oncology
- CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1Kankan Wang, Sebastian Kenny, Zhana Chagan, Lihong Li, Chittaranjan Das, Xing Liu · 2026 · Structure
- Atomic degradation: chemical design strategies and immunotherapeutic mechanisms of radio-PROTACsTuğba Ören Varol, Mehmet Varol · 2026 · Annals of Nuclear Medicine
- An iteratively curated CRISPR library reveals target-specific biological resistance landscapes across targeted protein degradersLin Liu, Olivia Voulgaris, Changqing Wang, Dáire Gannon, Matthew E. Ritchie, Rebecca Feltham, Stephin J. Vervoort · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- BindingDB Entry 50022940: Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50011187: Monovalent protein-degraders - Insights and future perspectives.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50017830: Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50016327: Selectivity through Targeted Protein Degradation (TPD).BindingDB · 2023 · UC San Diego
- Targeted Degradation of the c-Myc Oncoprotein: Molecular Mechanisms, Technological Platforms, and Therapeutic Perspectives in OncologyTatiana N. Lupanova, Georgii Pavlovich Georgiev, Alexander S. Sobolev · 2026 · Pharmaceutics