Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation

Mayor-Ruiz, Cristina, Jaeger, Martin G., Bauer, Sophie, Brand, Matthias, Sin, Celine, Hanzl, Alexander, Mueller, André C., Menche, Jörg +1 more·2019·Molecular Cell

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Items 101–122 of 122

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  6. The 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry
    Alessio Ciulli, Lawrence G. Hamann, Wolfgang Jahnke, Amit S.S. Kalgutkar, Thomas Magauer, Tobias Ritter, Vicky Steadman, S. D. Williams, Georg E. Winter, Klemens Hoegenauer et al. · 2021 · ChemMedChem
  7. Faculty Opinions recommendation of Major Advances in Targeted Protein Degradation: PROTACs, LYTACs, and MADTACs.
    John A. Lowe III · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  8. Faculty Opinions recommendation of Rational discovery of molecular glue degraders via scalable chemical profiling.
    Stevan W. Djurić · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  9. Strawberry COP9 signalosome FvCSN5A regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H 2 O 2 homeostasis
    Yun Huang, Jia Gao, Guiming Ji, Wenjing Li, Jiaxue Wang, Qinghua Wang, Yuanyue Shen, Jiaxuan Guo, Fan Gao · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA
    Mahsa Shirani, Ronaldo Shaquille Bowie, Michael D. Tomasini, Ruth Hook, Denise Ng, Bassem Shebl, Barbara A. Lyons, Philip Coffino, Sanford M. Simon · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variants
    Johannes W. Bigenzahn, F. Kartnig, Manuela Vollert, V. Sedlyarov, G. Superti-Furga · 2025 · bioRxiv
  12. PROTAC-Driven Protective Therapy increases the therapeutic window of anticancer drugs
    Lucía Simón-Carrasco, Soledad Raya, Elena Pietrini, Manuel Luque-Perez, Marta del Rio Oliva, Ivan Rosado, Andres Joaquin Lopez-Contreras · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Dual Target E3 Ligase Ligands: A New Way to Overcome Drug Resistance
    相奕 潘 · 2026 · Hans Journal of Medicinal Chemistry
  14. Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
    Jiaye Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang · 2026 · MedComm – Oncology
  15. CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1
    Kankan Wang, Sebastian Kenny, Zhana Chagan, Lihong Li, Chittaranjan Das, Xing Liu · 2026 · Structure
  16. Atomic degradation: chemical design strategies and immunotherapeutic mechanisms of radio-PROTACs
    Tuğba Ören Varol, Mehmet Varol · 2026 · Annals of Nuclear Medicine
  17. An iteratively curated CRISPR library reveals target-specific biological resistance landscapes across targeted protein degraders
    Lin Liu, Olivia Voulgaris, Changqing Wang, Dáire Gannon, Matthew E. Ritchie, Rebecca Feltham, Stephin J. Vervoort · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  18. BindingDB Entry 50022940: Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders.
    BindingDB · 2026 · UC San Diego
  19. BindingDB Entry 50011187: Monovalent protein-degraders - Insights and future perspectives.
    BindingDB · 2021 · UC San Diego
  20. BindingDB Entry 50017830: Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer.
    BindingDB · 2023 · UC San Diego
  21. BindingDB Entry 50016327: Selectivity through Targeted Protein Degradation (TPD).
    BindingDB · 2023 · UC San Diego
  22. Targeted Degradation of the c-Myc Oncoprotein: Molecular Mechanisms, Technological Platforms, and Therapeutic Perspectives in Oncology
    Tatiana N. Lupanova, Georgii Pavlovich Georgiev, Alexander S. Sobolev · 2026 · Pharmaceutics