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Cited by 35Complement system in diseasesBiomarkers in Disease MechanismsNeonatal and Maternal Infections

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Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations

Swierzko, Anna St., Cedzynski, Maciej, Domzalska-Popadiuk, Iwona, MacDonald, Shirley L., Borkowska-Klos, Monika, Atkinson, Anne P.M., Szala, Agnieszka, Jopek, Aleksandra, Jensenius, Jens C., Kawakami, Masaya, Szczapa, Jerzy, Matsushita, Misao, Szemraj, Janusz, Turner, Marc L., Kilpatrick, David C.·2009·Molecular Immunology
DOI 10.1016/j.molimm.2009.02.022
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Abstract

One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway. This property depends on the ability of these lectins to form complexes with MBL-associated serine proteases (MASPs), particularly MASP-2. We report the results of an investigation of cord blood MASP-2 concentrations in a large, ethnically homogeneous cohort (n=1788) of neonates. The median value of MASP-2 in cord sera was determined to be 93 ng/ml (range <25-812). Serum MASP-2 concentrations correlated with gestational age and birthweight and were significantly lower in premature babies and other pre-term babies compared with term babies. Neonates with MASP-2 concentrations below 42 ng/ml were deemed to be MASP-2 deficient. That group had a shorter mean gestational age and a higher incidence of premature and low birthweight babies, but not of perinatal infections when compared with the others. Indeed, there was a trend towards higher MASP-2 concentrations amongst babies with infections. Among 362 samples tested for the D120G single nucleotide polymorphism (SNP) of the MASP2 gene, no homozygote for that mutation was found. Heterozygosity for this allele significantly influenced the protein concentration, but not the lectin pathway of complement activity (MBL-MASP-2 complex activity). Moreover, no association of this SNP was apparent with prematurity, low birthweight or perinatal inf…

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  • A low-frequency missense variant in MASP2 (rs72550870, Asp120Gly, MAF = 3.0%), previously linked to MASP2 deficiency, is associated in trans with higher MASP1 levels (β = 0.17, P = 2.5 × 10 -15), reduced FCN2 levels (β = -0.22, P = 2.6 × 10 -32), higher FCN1 levels (β = 0.17, P = 1.4 × 10 -17) and lower C1QTNF9 levels (β = -0.12, P = 6.6 × 10 -14).

    “Similarly, we found a low-frequency missense variant in MASP2 (rs72550870, Asp120Gly, MAF = 3.0%), previously linked to MASP2 deficiency [47][48][49] , associated in trans with higher MASP1 levels (β = 0.17, P = 2.5 × 10 -15 ; independent to the primary association), reduced FCN2 levels (β = -0.22,P = 2.6 × 10 -32 ), higher FCN1 levels (β = 0.17, P = 1.4 × 10 -17 ) and lower C1QTNF9 levels (β = -0”

    From Plasma proteomic associations with genetics and health in the UK Biobank (2023) · cites this paper as [48]

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Research works printed but not linked: 29

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Metadata

Authors
Swierzko, A. S., Cedzynski, M., Domzalska-Popadiuk, I., MacDonald, S. L., Borkowska-Klos, M., Atkinson, A. P. M., Szala, A., Jopek, A., Jensenius, J. C., Kawakami, M., Szczapa, J., Matsushita, M., Szemraj, J., Turner, M. L., & Kilpatrick, D. C.
Affiliations
  • Scottish National Blood Transfusion Service (GB)
  • Poznan University of Medical Sciences (PL)
  • Institute for Medical Biology (PL)
  • Aarhus University (DK)
  • Kitasato University (JP)
  • Tokai University (JP)
  • Medical University of Lodz (PL)
ORCID
Venue
Molecular Immunology
Publisher
Elsevier BV
Published
2009-05
Volume
46
Issue
8-9
Pages
1696-1701
ISSN
0161-5890 (ISSN-L)
DOI
10.1016/j.molimm.2009.02.022
OpenAlex
W2084345289
Cited by
35
References
0
Citations by year
2023: 2 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2014: 1 · 2013: 5 · 2012: 2
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Royal Society of Edinburgh
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Keywords
MASP-2, mannose-binding lectin, MBL-associated serine proteases, lectin pathway, ficolins, umbilical cord blood, neonates, preterm birth, low birth weight, perinatal infection, heterozygosity, gestational age
MeSH terms
Birth Weight, Female, Fetal Blood, Genotype, Gestational Age, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Newborn, Diseases, Infections, Male, Cohort Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Premature Birth, Mannose-Binding Protein-Associated Serine Proteases

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