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Cited by 34Chemokine receptors and signalingNeuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

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Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke

He, Qianyi, Shi, Xiaojuan, Zhou, Bin, Teng, Junfang, Zhang, Chaoqi, Liu, Shasha, Lian, Jingyao, Luo, Benyan, Zhao, Guoqiang, Lu, Hong, Xu, Yuming, Lian, Yajun, Jia, Yanjie, Zhang, Yi·2018·Molecular Immunology
DOI 10.1016/j.molimm.2018.08.002
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Abstract

Granulocytes and natural killer (NK) cells have been linked to brain injury in ischemic stroke. However, their recruitment from peripheral leucocytes in stroke patients is not well understood. Here, the expression of the interleukin 8 (CXCL8) in plasma, and CXC chemokine receptor 2 (CXCR2) in peripheral leucocytes of patients with ischemic stroke were evaluated. Based on the results, CXCR2 expression positively correlated with granulocytes and NK cells, which were in turn attracted by CXCL8. The results also indicated that CXCR2 was a direct target of microRNA (miR)-4437, a negative regulator of CXCR2, which was downregulated in peripheral leucocytes from patients with ischemic stroke. Furthermore, serum CXCL8 levels were associated with the infarct volume and functional outcomes in patients with ischemic stroke. The results of the receiver operating characteristic curve analysis with an optimal cut-off value of 34 pg/mL indicated serum CXCL8 levels could be a prognostic indicator for ischemic stroke. In conclusion, these data highlighted the involvement of the CXCL8-CXCR2 chemotactic axis in the recruitment of granulocytes and NK cells in ischemic stroke. Furthermore, miR-4437 was suggested as a novel target for treating ischemic stroke, while the serum CXCL8 level could be a prognostic factor for ischemic stroke.

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Metadata

Authors
He, Q., Shi, X., Zhou, B., Teng, J., Zhang, C., Liu, S., Lian, J., Luo, B., Zhao, G., Lu, H., Xu, Y., Lian, Y., Jia, Y., & Zhang, Y.
Affiliations
  • First Affiliated Hospital of Zhengzhou University (CN)
  • Zhengzhou University (CN)
  • First Affiliated Hospital Zhejiang University (CN)
Corresponding author
Zhang, Yi
ORCID
Venue
Molecular Immunology
Publisher
Elsevier BV
Published
2018-09
Volume
101
Pages
440-449
ISSN
0161-5890 (ISSN-L)
DOI
10.1016/j.molimm.2018.08.002
OpenAlex
W2885558672
Cited by
34
References
51
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 1
FWCI
1.13
Type
journal article
Language
en
Update notices
erratum (2022-06-01)
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
American Heart Association
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
ischemic stroke, interleukin-8, CXCR2, granulocytes, natural killer cells, chemokine recruitment, serum biomarkers, prognostic factors, infarct size, functional outcome, microRNA target regulation
MeSH terms
Base Sequence, Brain Ischemia, Chemotaxis, Female, Granulocytes, Humans, Killer Cells, Natural, Male, Middle Aged, Prognosis, Down-Regulation, Up-Regulation, Interleukin-8, Stroke, Receptors, Interleukin-8B, MicroRNAs

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