Differentiation and functional plasticity of gamma-delta (γδ) T cells under homeostatic and disease conditions
Abstract
Gamma-delta (γδ) T cells are a heterogeneous population of immune cells, which constitute <5% of total T cells in mice lymphoid tissue and human peripheral blood. However, they comprise a higher proportion of T cells in the epithelial and mucosal barrier, where they perform immune functions, help in tissue repair, and maintaining homeostasis. These tissues resident γδ T cells possess properties of innate and adaptive immune cells which enables them to perform a variety of functions during homeostasis and disease. Emerging data suggest the involvement of γδ T cells during transplant rejection and survival. Interestingly, several functions of γδ T cells can be modulated through their interaction with other immune cells. This review provides an overview of development, differentiation plasticity into regulatory and effector phenotypes of γδ T cells during homeostasis and various diseases.
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γδ T cells mostly reside within tissues, particularly in epithelial layers, where they might play tissue-protective or inflammatory roles.
“γδ T cells mostly reside within tissues, particularly in epithelial layers, where they might play tissue-protective or inflammatory roles (5).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [5]
The development of mouse γδ T cells and their subsets depends critically on IL-7 and IL-15.
“The development of mouse γδ T cells and their subsets depends critically on IL-7 and IL-15 (5).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [5]
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Wu, P., Wu, D., Ni, C., Ye, J., Chen, W., Hu, G., Wang, Z., Wang, C., Zhang, Z., Xia, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.013 · Cited by 608 · see citing works
MICA Engagement by Human Vγ2Vδ2 T Cells Enhances Their Antigen-Dependent Effector Function
Das, H., Groh, V., Kuijl, C., Sugita, M., Morita, C. T., Spies, T., & Bukowski, J. F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00168-6 · Cited by 409 · see citing works
Ye, J., Ma, C., Hsueh, E. C., Eickhoff, C. S., Zhang, Y., Varvares, M. A., Hoft, D. F., & Peng, G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202369 · Cited by 203 · see citing works
Bhagat, G., Naiyer, A. J., Shah, J. G., Harper, J., Jabri, B., Wang, T. C., Green, P. H. R., & Manavalan, J. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci30989 · Cited by 188 · see citing works
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation
Ribeiro, S. T., Ribot, J. C., & Silva-Santos, B. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00015 · Cited by 116 · see citing works
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Comparing Mouse and Human Tissue-Resident γδ T Cells
Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891687 · Cited by 87 · see citing works
- Authors
- Giri, S., & Lal, G.
- Affiliations
- National Centre for Cell Science (IN)
- Corresponding author
- Lal, Girdhari
- Venue
- Molecular Immunology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 136
- Pages
- 138-149
- ISSN
- 0161-5890 (ISSN-L)
- OpenAlex
- W3171244696
- Cited by
- 37
- References
- 5
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 10 · 2023: 2 · 2022: 13 · 2021: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Science and Engineering Research Board (DST/SJF/LSA-01/2017-18, EMR/2016/007108)
- Department of Biotechnology, Ministry of Science and Technology, India (BT/PR14156/BRB/10/1515/2016, BT/PR15533/MED/30/1616/2015)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- γδ T cells, T cell differentiation, functional plasticity, regulatory T cells, effector T cells, mucosal immunity, epithelial barrier function, graft rejection, tissue repair, innate and adaptive immunity, immune homeostasis, disease
- MeSH terms
- Cell Plasticity, Animals, Graft Rejection, Humans, Immune Tolerance, Immunity, Innate, T-Lymphocytes, Receptors, Antigen, T-Cell, gamma-delta, Mice, Adaptive Immunity
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