Optimization of rivastigmine nanoemulsion for enhanced brain delivery: In-vivo and toxicity evaluation
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In vivo studies showed that the brain drug concentration after nasal administration of rivastigmine nanoemulsions was significantly higher than that achieved after nasal administration of solutions and intravenous administration of nanoemulsions.
“In vivo studies showed that the brain drug concentration after nasal administration of NEs was significantly higher than that achieved after nasal administration of solutions and intravenous administration of NEs.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [75]
Ex vivo diffusion studies on goat nasal mucosa showed that the cumulative amount of rivastigmine permeation through nasal mucosa for nanoemulsion was higher than that of the drug solution used as a comparison.
“Ex vivo diffusion studies done on goat nasal mucosa showed that the cumulative amount of drug permeation through nasal mucosa for NE was higher than that of the drug solution used as a comparison.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [75]
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References 40 · Cited by 68
- Authors
- Haider, M. F., Khan, S., Gaba, B., Alam, T., Baboota, S., Ali, J., & Ali, A.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Ali, Asgar
- Venue
- Journal of Molecular Liquids
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 255
- Pages
- 384-396
- ISSN
- 0167-7322 (ISSN-L)
- OpenAlex
- W2793557516
- Cited by
- 68
- References
- 40
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 13 · 2023: 6 · 2022: 6 · 2021: 13 · 2020: 4 · 2019: 6
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Liquids (publishedVersion)
- Funders
- Hamdard National Foundation
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- rivastigmine, nanoemulsions, intranasal drug delivery, brain drug delivery, bioavailability, drug release, toxicity, nasal mucosa, pharmaceutical excipients
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