Thymosin β: actin-sequestering protein moonlights to repair injured tissues
Abstract
Here, we review the biochemical and molecular properties of thymosin beta(4) (Tbeta(4)), the major actin-sequestering molecule in eukaryotic cells, and its key role in dermal- and corneal-wound healing. Tbeta(4) has several, novel, potential clinical applications in the repair and remodeling of ulcerated tissues and solid organs following hypoxic injuries, such as myocardial infarction and stroke. It might also have important repair functions in the pathophysiologic sequelae that are associated with actin toxicity and with septic shock, such as respiratory distress syndrome, multi-organ failure and severe tissue trauma.
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Tβ4 has clear anti-inflammatory and wound healing activities.
“As reviewed recently, (Goldstein et al., 2005), Tβ4 has clear anti-inflammatory and wound healing activities.”
From Thymosin beta 4 suppression of corneal NFκB: A potential anti-inflammatory pathway (2007) · cites this paper as Goldstein et al., 2005
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References 70 · Cited by 250
- Authors
- GOLDSTEIN, A., HANNAPPEL, E., & KLEINMAN, H.
- Affiliations
- George Washington University (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- National Institutes of Health (US)
- Corresponding author
- GOLDSTEIN, A
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 11
- Issue
- 9
- Pages
- 421-429
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2078624058
- Cited by
- 250
- References
- 70
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 14 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 14 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 8 · 2013: 13 · 2012: 23
- FWCI
- 17.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- thymosin beta 4, actin sequestration, wound healing, skin wound healing, corneal wound healing, tissue repair, myocardial infarction, stroke, hypoxic injury, septic shock, respiratory distress syndrome, multiple organ failure, tissue trauma
- MeSH terms
- Thymosin beta(4), Actins, Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Neoplasms, Thymosin, Wound Healing
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