The role of innate immunity activation in house dust mite allergy
Abstract
House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgE directed towards mite allergens, recent studies have demonstrated that innate immunity activation also plays a critical role in HDM-induced allergy pathogenesis. HDM allergens can not only be considered proteins that induce adaptive Th2-biased responses in susceptible subjects but also as strong activators of innate immune cells, including skin keratinocytes and airway epithelial cells. The contribution of microbial adjuvant factors, derived from HDM carriers or the environment, is also essential in such cell stimulation. This review highlights how HDM allergens, together with microbial compounds, promote allergic responses through pattern recognition receptor-dependent pathways.
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House dust mite (HDM) is the most prevalent cause of allergic sensitization and a risk factor for persistent asthma in human subjects.
“Among many factors, house dust mite (HDM) is the most prevalent cause of allergic sensitization [4, 6], and a risk factor for persistent asthma in human subjects [7, 8].”
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“In this study, we used an HDM-based model of allergic airway in fl ammation, by administering house dust mite extract intratracheally to mice, which better imitates the human sensitization by taking the way through the airways including immediate innate immune response (66).”
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“But, by serving as potent triggers for innate immune cells within the airway epithelium, they promote allergic reactions via pathways dependent on pattern recognition receptors [25].”
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“mediated by a Th2-biased, allergen-specific immune response, accumulating evidence in recent years has suggested that innate immunity also plays a critical role in pathogenesis of allergic diseases (1, 2).”
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- Authors
- Jacquet, A.
- Affiliations
- Chulalongkorn University (TH)
- Corresponding author
- Jacquet, Alain
- ORCID
- Jacquet, Alain
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 17
- Issue
- 10
- Pages
- 604-611
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2070841999
- Cited by
- 126
- References
- 0
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 18 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 6 · 2013: 12 · 2012: 6
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- house dust mite allergy, innate immunity, Th2 cells, IgE, keratinocytes, airway epithelial cells, pattern recognition receptors, allergic inflammation, mite allergens
- MeSH terms
- Animals, Humans, Hypersensitivity, Immunity, Innate, Inflammation, Lectins, C-Type, Antigens, Dermatophagoides, Pyroglyphidae, Receptors, Proteinase-Activated, Toll-Like Receptors
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