Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
Open accessAbstract
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are frequently expressed in various tumors and their expression levels correlate with tumor growth, invasiveness, drug resistance, and poor clinical outcomes. Emerging experimental evidence demonstrates that PDGFs exhibit multiple functions in modulation of tumor growth, metastasis, and the tumor microenvironment by targeting malignant cells, vascular cells, and stromal cells. Understanding PDGF-PDGFR-mediated molecular signaling may provide new mechanistic rationales for optimizing current cancer therapies and the development of future novel therapeutic modalities.
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The largest overlap of deregulated genes was identified between adagrasib plus BI-3406 and adagrasib plus TNO155 combination treatments, suggesting similarly induced transcriptomic modulation.
“Across all time points in both models, the largest overlap of deregulated genes, which included genes associated with the MAPK family, tumor growth and cancer progression28–30, was identified between adagrasib plus BI-3406 and adagrasib plus TNO155 combination treatments, suggesting similarly induced transcriptomic modulation (Fig. 4a, Extended Data Fig. 4 and Supplementary Tables 6 and 7).”
From Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance (2024) · cites this paper as [29]
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References 182 · Cited by 190
- Authors
- Cao, Y.
- Affiliations
- Linköping University (SE)
- Corresponding author
- Cao, Yihai
- ORCID
- Cao, Yihai
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 19
- Issue
- 8
- Pages
- 460-473
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2076971387
- Cited by
- 190
- References
- 182
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 18 · 2023: 13 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 23 · 2018: 22 · 2017: 23 · 2016: 20 · 2015: 12 · 2014: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- platelet-derived growth factor, PDGF receptor, tumor growth, metastasis, tumor microenvironment, drug resistance, tumor invasion, vascular cells, stromal cells, cancer therapy
- MeSH terms
- Animals, Humans, Neoplasm Metastasis, Neoplasms, Platelet-Derived Growth Factor, Signal Transduction, Receptors, Platelet-Derived Growth Factor
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