Microbiota impact on the epigenetic regulation of colorectal cancer
Open accessAbstract
Mechanisms of colorectal cancer (CRC) development can be generally divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota. Aberrant gut microbial composition, termed 'dysbiosis', has been reported in inflammatory bowel disease patients who are at increased risk for CRC development. Recent studies indicate that it is feasible to rescue experimental models of colonic cancer by oral treatment with genetically engineered beneficial bacteria and/or their immune-regulating gene products. Here, we review the mechanisms of epigenetic modulation implicated in the development and progression of CRC, which may be the result of dysbiosis, and therefore may be amenable to therapeutic intervention.
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The gut microbiome induces host epigenetic changes that might contribute to the development of cancer.
“The gut microbiome has been shown to induce host epigenetic changes that might contribute to the development of cancer193,194”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [194]
The gut epithelium is dynamic, has high regenerative capacity, and is epigenetically modified by the gut microbiota and their metabolites.
“The gut epithelium is dynamic, has high regenerative capacity and is epigenetically modified by the gut microbiota and their metabolites194.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [194]
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References 119 · Cited by 90
Research works printed but not linked: 2
- [26]Sekirov I Gut microbiota in health and disease. Physiol Rev 2010 90 859 904 20664075
- [111]Khazaie K Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A 2012 109 10462 10467 22689992 PMC3387103
- Authors
- Yang, T., Owen, J. L., Lightfoot, Y. L., Kladde, M. P., & Mohamadzadeh, M.
- Affiliations
- University of Florida Health (US)
- University of Florida (US)
- Corresponding author
- Mohamadzadeh, Mansour
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 19
- Issue
- 12
- Pages
- 714-725
- ISSN
- 1471-4914 (ISSN-L)
- PMC
- PMC3851951
- OpenAlex
- W2045494646
- Cited by
- 90
- References
- 119
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 15 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 4 · 2015: 15 · 2014: 4
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA111002, L30 CA111002)
- National Institute of Allergy and Infectious Diseases (1R01AI098833-01, R01AI093370)
- National Center for Research Resources (UL1RR029890)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal cancer, gut microbiota, dysbiosis, epigenetic regulation, inflammatory bowel disease, probiotics, immune regulation, tumor progression
- MeSH terms
- Animals, Bacteria, Humans, Colorectal Neoplasms, Gastrointestinal Tract, Epigenesis, Genetic, Microbiota
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